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Thyroid Carcinoma

  • Chapter
Prognostic Factors in Cancer

Abstract

One of the earliest studies on prognostic factors in thyroid cancer involved a multivariate analysis of the EORTC (European Organisation for Research on Treatment of Cancer) Thyroid Cancer Cooperative Group [9]. This study combined all histologies and found survival to depend on histological types. The 5- year survival ranged from 80% in differentiated carcinoma (papillary and follicular), to 55% in medullary carcinoma to 10% in anaplastic carcinoma. This was incorporated in the EORTC prognostic index. Subsequently, most studies of prognostic factors in thyroid cancer were developed for these histological types separately. Recently, the Italian Association of Surgical Oncology (SICO) [2, 15] has confirmed the significance of histological types. They found a similar survival for both papillary and follicular carcinoma, 97% and 95% at 4 years, a slightly lower survival for medullary carcinoma (91.3%) and an extremely poor survival for anaplastic carcinoma. Medullary carcinoma is derived from the parafollicular cells. The differentiated papillary and follicular carcinomas and the anaplastic carcinoma are derived from the follicular epithelium. In view of differences in treatment approaches, natural history and outcome, papillary-follicular, medullary and anaplastic carcinomas will be considered separately in this review.

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Authors
  1. A. Antonaci
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  2. J. Brierley
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  3. G. Bacchi
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  4. F. Consorti
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  5. C. Consoli
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  6. A. Manzini
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  7. M. Tagliaferri
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  8. F. Ficulccilli
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  9. F. Menichelli
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  10. C. Miani
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  11. P. Miani
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  12. M. Di Paola
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  13. M. Piemonte
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Editor information

Editors and Affiliations

  1. Chirurgische Universitätsklinik Erlangen, Krankenhausstr. 12, 91054, Erlangen, Germany

    P. Hermanek (Vorstand der Abteilung für Klinische Pathologie i. R.) (Vorstand der Abteilung für Klinische Pathologie i. R.)

  2. Princess Margaret Hospital, Department of Radiation Oncology, University of Toronto, 500 Sherbourne Street, Toronto, Ontario, M4X 1K9, Canada

    Mary K. Gospodarowicz

  3. Early Detection Branch, Division of Cancer Prevention and Control, National Cancer Institute, EPN Building, Room 305 9000 Rockville Pike, Bethesda, MD, 20892, USA

    D. E. Henson

  4. University of Medicine and Dentistry, New Jersey Medical School, Newark, NJ, USA

    R. V. P. Hutter (Clinical Professor of Pathology) (Clinical Professor of Pathology)

  5. Department of Pathology, Saint Barnabas Medical Center, Old Short Hills Road, Livingston, NJ, 07039, USA

    R. V. P. Hutter (Clinical Professor of Pathology) (Clinical Professor of Pathology)

  6. Uniformed Services University of the Health Sciences, Bethesda, MD, USA

    L. H. Sobin (Professor of Pathology) (Professor of Pathology)

  7. Division of Gastrointestinal Pathology, Armed Forces Institute of Pathology, Washington, DC, 20306, USA

    L. H. Sobin (Professor of Pathology) (Professor of Pathology)

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© 1995 International Union Against Cancer, Geneva

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Antonaci, A. et al. (1995). Thyroid Carcinoma. In: Hermanek, P., Gospodarowicz, M.K., Henson, D.E., Hutter, R.V.P., Sobin, L.H. (eds) Prognostic Factors in Cancer. UICC International Union Against Cancer / Union Internationale Contre le Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79395-0_4

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  • DOI: https://doi.org/10.1007/978-3-642-79395-0_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-58688-3

  • Online ISBN: 978-3-642-79395-0

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