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Toxicology of Cadmium

  • Chapter
Toxicology of Metals

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 115))

Abstract

Cadmium (Cd) is unique among metals because of its diverse toxic effects, extremely protracted biological half-life (approximately 20–30 years in humans), low rate of excretion from the body, and predominant storage in soft tissues (primarily liver and kidney) rather than bone. The health hazards associated with cadmium exposure became known in the 1940s when FRiberg (1948) reported the occurrence of emphysema and proteinuria in workers exposed to cadmium dust. In the 1960s, cadmium was catapulted into the mainstream of metal toxicology research when cadmium was identified as the major etiological factor in itai-itai disease, a condition that afflicted Japanese women exposed to cadmium via their diet which contained cadmium-contaminated rice and water. Cadmium is an extremely toxic element of continuing concern because environmental levels have risen steadily due to continued worldwide anthropogenic mobilization. The mobilization has derived from past and current industrial and agricultural practices.

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References

  • Abd Elghany N, Schumacher MC, Slattery M, West DW, Lee JS (1990) Occupation, cadmium exposure, and prostate cancer. Epidemiol 1:107–115

    Google Scholar 

  • Akerman KEO, Honkaniemi J, Scott IG, Andersson LC (1985) Interaction of Cd2+ with calmodulin activated (Ca2++ Mg2+)-ATPase activity of human erythrocyte ghosts. Biochim Biophys Acta 845:48–53

    PubMed  CAS  Google Scholar 

  • Amoruso MA, Witz G, Goldstein BD (1982) Enhancement of rat and human phagocyte superoxide anion radical production by cadmium in vitro. Toxicol Lett 10:133–138

    PubMed  CAS  Google Scholar 

  • Andersson T, Drakenberg T, Forsen S, Thulin E (1982) Characterization of the Ca2+ binding sites of calmodulin from bovine testis using 43Ca and 113Cd NMR. Eur J Biochem 126:501–505

    PubMed  CAS  Google Scholar 

  • Bako G, Smith ESO, Hanson J, Dewar R (1982) The geographical distribution of high cadmium concentrations in the environment and prostate cancer in Alberta. Can J Public Health 73:92–94

    PubMed  CAS  Google Scholar 

  • Berg JW, Burbank F (1972) Correlations between carcinogenic trace metals in the water supplies and cancer mortality. Ann NY Acad Sci 199:249–264

    PubMed  CAS  Google Scholar 

  • Bernard A, Lauwerys R (1986) Effects of cadmium exposure in man. In:Foulkes EC (ed) Cadmium toxicology. Springer, Berlin Heidelberg New York, pp 135–177 (Handbook of experimental pharmacology, vol 80 )

    Google Scholar 

  • Bhattacharyya MH (1991) Cadmium-induced bone loss:increased susceptibility in females. Water Air Soil Pollution 57–58:665–673

    Google Scholar 

  • Blakley BR (1986) The effect of cadmium- and viral-induced tumor production in mice. J Appl Toxicol 6:425–429

    PubMed  CAS  Google Scholar 

  • Campbell TC, Chen J, Liu C, Li J, Parpia B (1990) Nonassociation of aflatoxin with primary liver cancer in a cross-sectional ecological survey in the Peoples Republic of China. Cancer Res 50:6882–6893

    PubMed  CAS  Google Scholar 

  • Chao SH, Suzuki Y, Zysk JR, Cheung WY (1984) Activation of calmodulin by various metal cations as a function of ionic radius. Mol Pharmacol 26:75–82

    PubMed  CAS  Google Scholar 

  • Chatterjee MS, Abdel-Rahman M, Klein P, Bogden J (1988) Amniotic fluid cadmium and thiocyanate in pregnant women who smoke. J Reprod Med 33:417–420

    PubMed  CAS  Google Scholar 

  • Chen Y-C, Smith JB (1992) A putative lectin-binding receptor mediates cadmium-evoked calcium release. Toxicol Appl Pharmacol 117:249–256

    PubMed  CAS  Google Scholar 

  • Cherian MG, Goyer RA, Delaquerriere-Richardson L (1976) Cadmium-metallothionein-induced nephrotoxicity. Toxicol Appl Pharmacol 38:399–408

    PubMed  CAS  Google Scholar 

  • Cheung WY (1982) Calmodulin. Sci Am 246:62–70

    PubMed  CAS  Google Scholar 

  • Cheung WY (1984) Calmodulin:its potential role in cell proliferation and heavy metal toxicity. Fed Proc 43:2995–2999

    PubMed  CAS  Google Scholar 

  • Cihak A (1979) Metabolic alterations of liver regeneration. XV. Cadmium-mediated depression of thymidine and thymidylate kinase induction in rats. Chem Biol Interact 25:355–362

    PubMed  CAS  Google Scholar 

  • Coogan TP, Bare RM, Waalkes MP (1992) Cadmium-induced DNA damage:effects of zinc pretreatment. Toxicol Appl Pharmacol 113:227–233

    PubMed  CAS  Google Scholar 

  • Coogan TP, Bare RM, Bjornson EJ, Waalkes MP (1994) Enhanced metallothionein gene expression protects against cadmium genotoxicity in cultured rat liver cells. J Toxicol Environ Health (in press)

    Google Scholar 

  • Corcoran GB, Ray SD (1992) The role of the nucleus and other compartments in toxic cell death produced by alkylating hepatotoxicants. Toxicol Appl Pharmacol 113:167–183

    PubMed  CAS  Google Scholar 

  • Cox JL, Harrison SD Jr (1983) Correlation of metal toxicity with in vitro calmodulin inhibition. Biochem Biophys Res commun 115:106–111

    PubMed  CAS  Google Scholar 

  • Der R, Fahim Z, Yousef M, Fahim M (1977) Effects of cadmium on growth, sexual development and metabolism in female rats. Res Commun Chem Pathol Pharmacol 16:485–505

    PubMed  CAS  Google Scholar 

  • Descotes J (1992) Immunotoxicology of cadmium. In:Nordberg GF, Herber RFM, Alessio L (eds) Cadmium in the human environment:toxicity and carcinogenicity. Intl Agency Res Cancer, Lyon, France, pp 385–390

    Google Scholar 

  • Donnelly TE (1978) Effects of zinc chloride on the hydrolysis of cyclic GMP and cyclic AMP by the activator-dependent cyclic nucleotide phosphodiesterase from bovine heart. Biochim Biophys Acta 522:151–160

    PubMed  CAS  Google Scholar 

  • Dorian C, Gattone VH II, Klaassen CD (1992) Renal cadmium disposition and injuries as a result of accumulation of cadmium-metallothionein by the proximal convoluted tubules — a light microscopic autoradiography study with 109CdMT. Toxicol Appl Pharmacol 114:173–181

    PubMed  CAS  Google Scholar 

  • Druet P, Bernard A, Hirsch F, Weening JJ, Gengoux P, Mahieu P, Birkeland S (1982) Immunologically mediated glomerulonephritis induced by heavy metals. Arch Toxicol 50:187–194

    PubMed  CAS  Google Scholar 

  • Dudley RE, Klaassen CD (1984) Changes in hepatic glutathione concentration modify cadmium-induced hepatotoxicity. Toxicol Appl Pharmacol 72:530–538

    PubMed  CAS  Google Scholar 

  • Dudley RE, Svoboda DJ, Klaassen CD (1982) Acute exposure to cadmium causes severe liver injury in rats. Toxicol Appl Pharmacol 65:302–313

    PubMed  CAS  Google Scholar 

  • Dudley RE, Gammal LM, Klaassen CD (1985) Cadmium-induced hepatic and renal injury in chronically exposed rats:likely role of hepatic cadmium-metallothionein in nephrotoxicity. Toxicol Appl Pharmacol 77:414–426

    PubMed  CAS  Google Scholar 

  • Dunphy B (1967) Acute occupational cadmium poisoning:a critical review of the literature. J Occup Med 9:22–26

    PubMed  CAS  Google Scholar 

  • Dwivedi C (1983) Cadmium-induced sterility:possible involvement of the cholinergic system. Arch Environ Contam Toxicol 12:151–156

    PubMed  CAS  Google Scholar 

  • Eaton DL, Stacey NH, Wong K-L, Klaassen CD (1980) Dose-response effects of various metal ions on rat liver metallothionein, glutathione, heme oxygenase, and cytochrome P-450. Toxicol Appl Pharmacol 55:393–402

    PubMed  CAS  Google Scholar 

  • Elinder CG, Kjellström T, Hogstedt C, Anderson K, Spang G (1985) Cancer mortality of cadmium workers. Br J Ind Med 42:651–655

    PubMed  CAS  Google Scholar 

  • Faeder EJ, Chaney SP, King LC, Hinners TA, Bruce R, Fowler BA (1977) Biochemical and ultrastructural changes in livers of cadmium treated rats. Toxicol Appl Pharmacol 39:473–487

    PubMed  CAS  Google Scholar 

  • Ferm VH, Layton WM Jr (1979) Reduction in cadmium teratogenesis by prior cadmium exposure. Environ Res 18:347–350

    PubMed  CAS  Google Scholar 

  • Forsen S, Thulin E, Lilja H (1979) 113Cd NMR in the study of calcium binding proteins: troponin C. FEBS Lett 104:123–126

    PubMed  CAS  Google Scholar 

  • Foulkes EC (1978) Renal tubular transport of cadmium-metallothionein. Toxicol Appl Pharmacol 45:505–512

    PubMed  CAS  Google Scholar 

  • Fowler BA, Goering PL, Squibb KS (1987) Mechanism of cadmium-metallothionein induced nephrotoxicity:relationship to renal calcium metabolism. Experientia [Suppl] 52:661–668

    CAS  Google Scholar 

  • Fowler BA, Gandley RE, Akkerman M, Lipsky MM, Smith M (1991) Proximal tubule cell injury. In:Klaassen CD, Suzuki KT (eds) Metallothionein in biology and medicine. CRC Press, Boca Raton, FL, pp 311–321

    Google Scholar 

  • Friberg L (1948) Proteinuria and emphysema among workers exposed to cadmium and nickel dust in a storage battery plant. Proc Int Cong Ind Med 9:641–644

    Google Scholar 

  • Friberg L (1950) Health hazards in the manufacture of alkaline accumulators with special reference to chronic cadmium poisoning. Acta Med Scand 138:1–124

    Google Scholar 

  • Friberg L, Kjellström T, Nordberg GF (1986) Cadmium. In: Friberg L, Nordberg G, Vouk VB (eds) Handbook on the toxicology of metals, vol 2, 2nd edn. Elsevier, New York, pp 130–184

    Google Scholar 

  • Gabor S, Anca Z, Bordas E (1978) Cadmium-induced lipid peroxidation in kidney and testes:effect of zinc and copper. Rev Roum Biochim 15:113–117

    CAS  Google Scholar 

  • Giavini E, Prati M, Vismara C (1980) Effects of cadmium, lead, and copper on rat preimplantation embryos. Bull Environ Contam Toxicol 25:702–705

    PubMed  CAS  Google Scholar 

  • Girod C, Chauvineau A (1964) Nouvelles observations concernant l’influence duchlorure de cadmium sur le testicule du Singe Macacus irus. F Cuv C R Soc Biol (Paris) 158:2113–2115

    CAS  Google Scholar 

  • Glaser U, Hochrainer D, Otto FJ, Oldiges H (1990) Carcinogenicity and toxicity of four cadmium compounds inhaled by rats. Chem Environ Toxicol 27:153–162

    CAS  Google Scholar 

  • Goering PL, Klaassen CD (1983) Altered subcellular distribution of cadmium following cadmium pretreatment:possible mechanism of tolerance to cadmium-induced lethality. Toxicol Appl Pharmacol 70:195–203

    PubMed  CAS  Google Scholar 

  • Goering PL, Klaassen CD (1984) Zinc-induced tolerance to cadmium hepatotoxicity. Toxicol Appl Pharmacol 74:299–307

    PubMed  CAS  Google Scholar 

  • Goering PL, Squibb KS, Fowler BA (1985) Calcuria and proteinuria during cadmium-metallothionein-induced proximal tubule cell injury. In:Hemphill DD (ed) Trace substances in environmental health, vol XIX. University of Missouri Press, Columbia, pp 22–35

    Google Scholar 

  • Goering PL, Mistry P, Fowler BA (1987) Mechanisms of metal-induced cell injury. In:Haley TJ, Berndt WO (eds) Handbook of toxicology. Hemisphere, Washington DC, pp 384–425

    Google Scholar 

  • Goyer RA (1991) Toxic effect of metals. In:Amdur MO, Doull J, Klaassen CD (eds) Casarett and Doull’s toxicology, the basic science of poisons, 4th edn. McGraw-Hill Pergamon, New York, pp 623–680

    Google Scholar 

  • Goyer RA, Cherian MG (1992) Role of metallothionein in human placenta and rats exposed to cadmium. In:Nordberg GF, Herber RFM, Alessio L (eds) Cadmium in the human environment. IARC, Lyon, pp 239–247

    Google Scholar 

  • Gregus Z, Watkins JB, Thompson TN, Klaassen CD (1982) Resistance of some phase II biotransformation pathways to hepatotoxins. J Pharmacol Exp Ther 222:471–479

    PubMed  CAS  Google Scholar 

  • Gunn SA, Gould TC, Anderson WAD (1963a) The selective injurious response of testicular and epididymal blood vessels to cadmium and its prevention by zinc. Am J Pathol 42:685–702

    CAS  Google Scholar 

  • Gunn SA, Gould TC, Anderson WAD (1963b) Cadmium-induced interstitial cell tumors in rats and mice and their prevention by zinc. J Natl Cancer Inst 31:745–753

    PubMed  CAS  Google Scholar 

  • Gunn SA, Gould TC, Anderson WAD (1964) Effect of zinc on cancerogenesis by cadmium. Proc Soc Exp Biol Med 115:653–657

    PubMed  CAS  Google Scholar 

  • Habermann E, Crowell K, Janicki P (1983) Lead and other metals can substitute for Ca2+ in calmodulin. Arch Toxicol 54:61–70

    PubMed  CAS  Google Scholar 

  • Haddow A, Roe FJC, Dukes CE, Mitchely BCV (1964) Cadmium neoplasia:sarcomata at the site of injection of cadmium in rats and mice. Br J Cancer 18:667–673

    PubMed  CAS  Google Scholar 

  • Hadley WM, Miya TS, Bousquet WF (1974) Cadmium inhibition of hepatic drug metabolism in the rat. Toxicol Appl Pharmacol 28:284–291

    PubMed  CAS  Google Scholar 

  • Harrison PTC, Heath JC (1986) Apparent synergy in lung carcinogenesis:interactions between N-nitrosoheptamethyleneimine, particulate cadmium and crocidolite asbestos fibers in rats. Carcinogenesis 7:1903–1908

    PubMed  CAS  Google Scholar 

  • Heath JC, Daniel MR, Dingle JT, Webb M (1962) Cadmium as a carcinogen. Nature 193:592–593

    PubMed  CAS  Google Scholar 

  • Heinrich U, Peters L, Ernst H, Rittinghausen S, Dasenbrock C, König H (1989) Investigation of the carcinogenic effects of various compounds after inhalation in hamsters and mice. Exp Pathol 37:253–258

    PubMed  CAS  Google Scholar 

  • Hildebrand CE, Griffith JK, Tobey RA, Walters RA, Enger MD (1982) Molecular mechanisms of cadmium detoxification in cadmium-resistant cultured cells:role of metallothionein and other inducible factors. In:Foulkes EC (ed) Biological roles of metallothionein. Elsevier/North-Holland, New York, pp 279–303

    Google Scholar 

  • IARC (1976) Cadmium, nickel, some epoxides, miscellaneous industrial chemicals and general considerations on volatile anesthetics. Lyon, France, pp 39–74 (International Agency for Research on Cancer monographs, vol 11)

    Google Scholar 

  • IARC (1993) Beryllium, cadmium, mercury, and exposures in the glass manufacturing industry. Intl Agency Res Cancer, vol 58. Lyon, France, pp 119–238

    Google Scholar 

  • Ishizu S, Minami M, Suzuki A, Yamada M, Sato M, Yamamura K (1973) An experimental study on teratogenic effect of cadmium. Ind Health 11:127–139

    CAS  Google Scholar 

  • Ito T, Sawauchi K (1966) Inhibitory effects on cadmium-induced testicular damage by pretreatment with smaller cadmium doses. Okajimas Fol Anat Jpn 42:107–117

    CAS  Google Scholar 

  • Izatt R, Christensen J, Rytting J (1971) Sites and thermodynamic quantities with proton and metal ion interactions with ribonucleic acid, deoxyribonucleic acid, and their constituent bases, nucleosides and nucleotides. Chem Rev 71:439–481

    PubMed  CAS  Google Scholar 

  • Jin P, Ringertz N (1990) Cadmium induces transcription of protooncogenes c-jun and c-myc in rat L6 myoblasts. J Biol Chem 265:14061–14064

    PubMed  CAS  Google Scholar 

  • Kägi JHR, Hapke H-J (1984) Biochemical interactions of mercury, cadmium, and lead. In:Nriagu JO (ed) Changing metal cycles and human health. Springer, Berlin Heidelberg New York, pp 237–250

    Google Scholar 

  • Kang Y-J, Clapper JA, Enger MD (1989) Enhanced cadmium cytotoxicity in A549 cells with reduced glutathione levels is due to neither enhanced cadmium accumulation nor reduced metallothionein synthesis. Cell Biol Toxicol 5:249–260

    PubMed  CAS  Google Scholar 

  • Kasparzak KS (1990). Metal interactions in nickel, cadmium and lead carcinogenesis. In: Foulkes EC (ed) Biological effects of heavy metals, vol II: metal carcinogenesis. CRC Press, Boca Raton, FL, pp 173–189

    Google Scholar 

  • Kazantzis G (1963) Induction of sarcoma in the rat by cadmium sulphide pigment. Nature 198:1213–1214

    PubMed  CAS  Google Scholar 

  • Kazantzis G (1986) Cadmium:sources, exposure and possible carcinogenicity. In:O’Neill IK, Schuller P, Fishbein L (eds) Environmental carcinogens selected methods of analysis, vol 8. IARC, Lyon, France, pp 93–100

    Google Scholar 

  • Kazantzis G (1987) Cadmium. In:Fishbein L, Fürst A, Mehlman MA (eds) Advances in modern toxicology, vol XI. Princeton Scientific, Princeton, NJ, pp 127–143

    Google Scholar 

  • Kazantzis G, Lam TH, Sullivan K (1988) Mortality of cadmium exposed workers. Scand J Work Environ Health 14:220–223

    PubMed  CAS  Google Scholar 

  • Kido T, Honda R, Tsuritani I, Yamaya H, Ishizaki M, Yamada Y, Nogawa K (1988) Progress of renal dysfunction in inhabitants environmentally exposed to cadmium. Arch Environ Health 43:213–217

    PubMed  CAS  Google Scholar 

  • Kido T, Nogawa K, Honda R, Tsuritani I, Ishizaki M, Yamada Y, Nakagawa H (1990) The aassociation between renal dysfunction and osteopenia in environmental cadmium-exposed subjects. Environ Res 51:71–82

    PubMed  CAS  Google Scholar 

  • Kipling MD, Waterhouse JAH (1967) Cadmium and prostatic carcinoma. Lancet 1:730–731

    Google Scholar 

  • Kjellström T (1986) Itai-itai disease. In: Friberg L, Elinder CG, Kjellström T, Nordberg GF (eds) Cadmium and health: a toxicological and epidemiological appraisal, vol II, effects and response. CRC Press, Boca Raton, FL, pp 257–290

    Google Scholar 

  • Klaassen CD (1990) Heavy metals and heavy-metal antagonists. In:Gilman AG, Rail TW, Nies AS, Taylor P (eds) Goodman and Gilman’s the pharmacological basis of therapeutics. McGraw-Hill, New York, pp 1592–1614

    Google Scholar 

  • Koller LD (1980) Review/commentary:immunotoxicology of heavy metals. Intl J Immunopharmacol 2:269–279

    CAS  Google Scholar 

  • Koller LD, Exon JH, Roan JG (1975) Antibody suppression by cadmium. Arch Environ Health 30:598–601

    PubMed  CAS  Google Scholar 

  • Kolonel LN (1976) Association of cadmium with renal cancer. Cancer 37:1782–1787

    PubMed  CAS  Google Scholar 

  • Kotsonis FN, Klaassen CD (1977) Toxicity and distribution of cadmium administered to rats at sublethal doses. Toxicol Appl Pharmacol 41:667–680

    PubMed  CAS  Google Scholar 

  • Kotsonis FN, Klaassen CD (1978) The relationship of metallothionein to the toxicity of cadmium after prolonged oral administration to rats. Toxicol Appl Pharmacol 46:39–54

    PubMed  CAS  Google Scholar 

  • Kurokawa Y, Matsushima M, Imazawa N, Takamura N, Takahashi M, Mayashi Y (1985) Promoting effect of metal compounds on rat renal tumorigenesis. J Am Coll Toxicol 4:321–327

    CAS  Google Scholar 

  • Lancet (1986) Carcinogenicity of cadmium. II:931

    Google Scholar 

  • Lauwerys R (1978) CEC criteria (dose/effect relationship) for cadmium. Pergamon, Oxford

    Google Scholar 

  • Lauwerys R, Bernard A, Buchet JP, Roels H, Bruaux P, Claeys F, Ducoffre G, DePlaen P, Staessen J, Amery A et al. (1991) Does environmental cadmium represent a health risk? Conclusions from the Cadmibel study. Acta Clin Belg 46:219–225

    PubMed  CAS  Google Scholar 

  • Leber AP, Miya TS (1976) A mechanism for cadmium and zinc-induced tolerance to cadmium toxicity:involvement of metallothionein. Toxicol Appl Pharmacol 37:403–414

    PubMed  CAS  Google Scholar 

  • Lemen RA, Lee JS, Wagoner JK, Blejer HP (1976) Cancer mortality among cadmium production workers. Ann NY Acad Sci 271:273–279

    PubMed  CAS  Google Scholar 

  • Lewis GP, Jusko WJ, Coughlin LL, Hartz S (1972) Cadmium accumulation in man:influence of smoking, occupation, alcoholic habit and disease. J Chronic Dis 25:717–726

    PubMed  CAS  Google Scholar 

  • Loeb L, Sirover M, Wymouth L, Dube D, Seal G, Agarwal S, Katz E (1977) Infidelity of DNA synthesis as related to mutagenesis and carcinogenesis. J Toxicol Environ Health 2:1297–1304

    PubMed  CAS  Google Scholar 

  • Lohiya NK, Arya M, Shivapuri VS (1976) The effects of cadmium chloride on the testis and epididymis of the Indian hanuman langur, Presbytis entellus entellus Dufresne. Acta Eur Fertil 7:339–348

    PubMed  CAS  Google Scholar 

  • Maines MD, Kappas A (1977) Metals as regulators of heme metabolism. Science 198:1215–1221

    PubMed  CAS  Google Scholar 

  • Maitani T, Waalkes MP, Klaassen CD (1984) Distribution of cadmium after oral administration of cadmium-thionein to mice. Toxicol Appl Pharmacol 74:237–243

    PubMed  CAS  Google Scholar 

  • Maitani T, Cuppage FE, Klaassen CD (1988) Nephrotoxicity of intravenously injected cadmium-metallothionein:critical concentration and tolerance. Fund Appl Toxicol 10:98–108

    CAS  Google Scholar 

  • Makowski GS, Lin S-M, Brennan SM, Smilowitz HM, Hopfer SM, Sunderman FW Jr (1991) Detection of two Zn-finger proteins of Xenopus laevis, TFIIIA, and p43, by probing Western blots of ovary cytosol with 65Zn2+, 63Ni2+, or 109Cd2+. Biol Trace Elem Res 29:93–109

    PubMed  CAS  Google Scholar 

  • Mason HJ, Davison AG, Wright AL, Guthrie CJ, Fayers PM, Venables KM, Smith NJ, Chettle DR, Franklin DM, Scott MC, Holden H, Gompertz D, Newman-Taylor A J (1988) Relations between liver cadmium, cumulative exposure, and renal function in cadmium alloy workers. Br J Ind Med 45:793–802

    PubMed  CAS  Google Scholar 

  • McLellan JA, Flanagan PR, Chamberlain MJ, Valberg LS (1978) Measurement of dietary cadmium absorption in humans. J Toxicol Environ Health 4:131–138

    PubMed  CAS  Google Scholar 

  • Means JR, Carlson GP, Schnell RC (1979) Studies on the mechanism of cadmium-induced inhibition of the hepatic microsomal monooxygenase of the male rat. Toxicol Appl Pharmacol 48:293–304

    PubMed  CAS  Google Scholar 

  • Meek ES (1959) Cellular changes induced by cadmium in mouse testis and liver. Br J Exp Pathol 40:503–506

    CAS  Google Scholar 

  • Mills JS, Johnson JD (1985) Metal ions as allosteric regulators of calmodulin. J Biol Chem 260:15100–15105

    PubMed  CAS  Google Scholar 

  • Miyake M, Murata I, Osabe M, Ono T (1979) Effect of metal cations on misincorporation by E. coli DNA polymerases. Biochem Biophys Res Commun 77:854–860

    Google Scholar 

  • Müller S, Gillert KE, Krause C, Jautzke G, Gross U, Diamantstein T (1979) Effects of cadmium on the immune system of mice. Experientia 35:909–910

    PubMed  Google Scholar 

  • Nakashima K, Wakisaka T, Fujiki Y (1988) Dose-response relationship of cadmium embryotoxicity in cultured mouse embryos. Reprod Toxicol 1:293–298

    CAS  Google Scholar 

  • Niewenhuis KJ, Prozialeck WC (1987) Calmodulin inhibitors protect against cadmium induced testicular damage in mice. Biol Reprod 37:127–133

    PubMed  CAS  Google Scholar 

  • Nogawa K, Tsuritani I, Kido T, Honda R, Yamada Y, Ishizaki M (1987) Mechanism for bone disease found in inhabitants environmentally exposed to cadmium:decreased 1,25-dihydroxy-vitamin D level. Int Arch Occup Environ Health 59:21–30

    PubMed  CAS  Google Scholar 

  • Nogawa K, Honda R, Kido T, Tsuritani I, Yamada Y, Ishizaki M, Ymaya H (1989) A dose-response analysis of cadmium in the general environment with special reference to total cadmium intake limit. Environ Res 48:7–16

    PubMed  CAS  Google Scholar 

  • Nomiyama K (1982) Carcinogenicity of cadmium. Jpn J Ind Health 24:13–23

    CAS  Google Scholar 

  • Nordberg GF (1989) Modulation of metal toxicity by metallothionein. Biol Trace Elem Res 21:131–135

    PubMed  CAS  Google Scholar 

  • Oberdörster G (1986) Airborne cadmium and carcinogenesis of the respiratory tract. Scand J Work Environ Health 12:523–537

    PubMed  Google Scholar 

  • Oberdörster G, Cox C (1990) Carcinogenicity of cadmium in animals:what is the significance for man? Chem Environ Toxicol 27:181–195

    Google Scholar 

  • Ochi T, Ishiguro T, Ohsawa M (1983) Participation of active oxygen species in the induction of DNA single-strand scissions by cadmium chloride in cultured Chinese hamster cells. Mutat Res 122:169–175

    PubMed  CAS  Google Scholar 

  • Ochi T, Otsuka F, Takahashi K, Ohsawa M (1988) Glutathione and metallothioneins as cellular defense against cadmium toxicity in cultured Chinese hamster cells. Chem Biol Interact 65:1–14

    PubMed  CAS  Google Scholar 

  • Oldiges H, Hochrainer D, Glaser U (1989) Preliminary results from a long-term inhalation study with four cadmium compounds. Toxicol Environ Chem 23:35–41

    Google Scholar 

  • Paksy K, Varga B, Horváth E, Tátrai E, Ungváry G (1989) Acute effects of cadmium on preovulatory serum FSH, LH, and prolactin levels and on ovulation and ovarian hormone secretion in estrous rats. Reprod Toxicol 3:241–247

    PubMed  CAS  Google Scholar 

  • Parizek J (1957) The destructive effect of cadmium ion on testicular tissue and its prevention by zinc. J Endocrinol 15:56–63

    PubMed  CAS  Google Scholar 

  • Parizek J, Oskadolova I, Bemes I, Pitha J (1968) The effect of a subcutaneous injection of cadmium salts on the ovaries of adult rat in persistent oestrus. J Reprod Fertil 17:559–562

    PubMed  CAS  Google Scholar 

  • Parzyck DC, Shaw SM, Kessler WV, Vetter RJ, VanSickle RJ, Mayes RA (1978) Fetal effects of cadmium in pregnant rats on normal and zinc-deficient diets. Bull Environ Contam Toxicol 19:206–214

    PubMed  CAS  Google Scholar 

  • Poirier LA, Kasprzak KS, Hoover KL, Wenk ML (1983) Effects of calcium and magnesium acetates on the carcinogenicity of cadmium chloride in Wistar rats. Cancer Res 43:4575–4581

    PubMed  CAS  Google Scholar 

  • Rehm S, Waalkes MP (1988) Cadmium-induced ovarian toxicity in hamsters, mice, and rats. Fund Appl Toxicol 10:635–647

    CAS  Google Scholar 

  • Richard G, Federolf G, Habermann E (1985) The interaction of aluminum and other metal ions with calcium-calmodulin-dependent phosphodiesterase. Arch Toxicol 57:257–259

    Google Scholar 

  • Roberts SA, Miya TS, Schnell RC (1976) Tolerance development to cadmium-induced alteration of drug action. Res Commun Chem Pathol Pharmacol 14:197–200

    PubMed  CAS  Google Scholar 

  • Roe FJC, Dukes CE, Cameron KM, Pugh RCD, Mitchley BCV (1964) Cadmium neoplasia:testicular atrophy and Ley dig cell hyperplasia and neoplasia in rats and mice following the subcutaneous injection of cadmium salts. Br J Cancer 18:674–681

    PubMed  CAS  Google Scholar 

  • Rossi A, Manzo L, Orrenius S, Vahter M, Nicotera P (1991) Modifications of cell signaling in the cytotoxicity of metals. Pharmacol Toxicol 68:424–429

    PubMed  CAS  Google Scholar 

  • Sacco-Gibson N, Chaudhry S, Brock A, Sickles AB, Patel B, Hegstad R, Johnston S, Peterson D, Bhattacharyya M (1992) Cadmium effects on bone metabolism:accelerated resorption in ovarectomized, aged beagle dogs. Toxicol Appl Pharmacol 113:274–283

    PubMed  CAS  Google Scholar 

  • Samarawickrama GP (1979) Biological effects of cadmium in mammals. In:Webb M (ed) The chemistry, biochemistry and biology of cadmium. Elsevier/North-Holland, New York, pp 341–421

    Google Scholar 

  • Shaikh Z (1991) Chronic cadmium exposure and metallothionein. In:Klaassen CD, Suzuki KT (eds) Metallothionein in biology and medicine. CRC Press, Boca Raton, FL, pp 383–391

    Google Scholar 

  • Shiraishi N, Rehm S, Waalkes MP (1994) Effect of chlorpromazine pretreatment on cadmium toxicity in the male Wistar ( WF/NCr) rat. J Toxicol Environ Health 42:123–138

    Google Scholar 

  • Shukla GS, Hussain T, Chandra SV (1987) Possible role of regional superoxide dismutase activity and lipid peroxide levels in cadmium neurotoxicity:in vivo and in vitro studies in growing rats. Life Sci 41:2215–2221

    PubMed  CAS  Google Scholar 

  • Sikorski R, Radomanski T, Paszkowski T, Skoda J (1988) Smoking during pregnancy and the perinatal body burden. J Perinat Med 16:225–231

    PubMed  CAS  Google Scholar 

  • Singhal RK, Anderson ME, Meister A (1987) Glutathione, a first line of defense against cadmium toxicity. FASEB J 1:220–223

    PubMed  CAS  Google Scholar 

  • Smith JB, Dwyer SD, Smith L (1989) Cadmium evokes inositol polyphosphate formation and calcium mobilization. Evidence for a cell surface receptor that cadmium stimulates and zinc antagonizes. J Biol Chem 264:7115–7118

    PubMed  CAS  Google Scholar 

  • Sporn A, Dinu I, Stoenescu L, Cirstea A (1969) Beitrage zur Ermittlung der Wechselwirkungen zwischen Cadmium und Zink. Nahrung 13:461–469

    CAS  Google Scholar 

  • Squibb KS, Pritchard JB, Fowler BA (1984) Cadmium metallothionein nephropathy:ultrastructural/biochemical alterations and intracellular cadmium binding. J Pharmacol Exp Ther 229:311–321

    PubMed  CAS  Google Scholar 

  • Stacey NH, Klaassen CD (1980) Cadmium uptake by isolated rat hepatocytes. Toxicol Appl Pharmacol 55:448–455

    PubMed  CAS  Google Scholar 

  • Stacey NH, Cantilena LR Jr, Klaassen CD (1980) Cadmium toxicity and lipid peroxidation in isolated rat hepatocytes. Toxicol Appl Pharmacol 53:470–480

    PubMed  CAS  Google Scholar 

  • Stayner L, Smith R, Thun M, Schorr T, Lernen R (1992) A dose-response analysis and quantitative assessment of lung cancer risk and occupational cadmium exposure. Ann Epidemiol 2:177–194

    PubMed  CAS  Google Scholar 

  • Stoeppler M (1991) Cadmium. In:Merian E (ed) Metals and their compounds in the environment. VCH, New York, pp 803–851

    Google Scholar 

  • Stoll R, White J, Miya T, Bousquet W (1976) Effects of cadmium on nucleic acid and protein synthesis in rat liver. Toxicol Appl Pharmacol 37:61–74

    PubMed  CAS  Google Scholar 

  • Stowe HD, Wilson M, Goyer RA (1972) Clinical and morphological effects of oral cadmium toxicity in rabbits. Arch Pathol 94:389–405

    PubMed  CAS  Google Scholar 

  • Sunderman FW Jr (1978) Carcinogenic effects of metals. Fed Proc 37:40–46

    PubMed  CAS  Google Scholar 

  • Sunderman FW Jr, Barber AM (1988) Finger loops, oncogenes, and metals. Ann Clin Lab Sci 18:267–288

    PubMed  CAS  Google Scholar 

  • Suzuki CAM, Cherian MG (1989) Renal glutathione depletion and nephrotoxicity of cadmium-metallothionein in rats. Toxicol Appl Pharmacol 98:544–552

    PubMed  CAS  Google Scholar 

  • Suzuki Y, Chao S-H, Zysk JR, Cheung WY (1985) Stimulation of calmodulin by cadmium ion. Arch Toxicol 57:205–211

    PubMed  CAS  Google Scholar 

  • Takenaka S, Oldiges H, König H, Hochrainer D, Oberdörster G (1983) Carcinogenicity of cadmium chloride aerosols in Wistar rats. J Natl Cancer Inst 70:367–373

    PubMed  CAS  Google Scholar 

  • Tang N, Enger D (1992) Cadmium’s action on NRK-49F cells to produce responses induced also by TGFß production or activation. Toxicology 71:161–171

    PubMed  CAS  Google Scholar 

  • Thun MJ, Schnorr TM, Smith AB, Halperin WE, Lernen RA (1985) Mortality among a cohort of U.S. cadmium production workers — an update. J Natl Cancer Inst 74:325–333

    PubMed  CAS  Google Scholar 

  • Thun MJ, Osorio AM, Schober S, Hannon WH, Lewis B, Halperin W (1989) Nephropathy in cadmium workers:assessment of risk from airborne occupational exposure to cadmium. Br J Ind Med 46:689–697

    PubMed  CAS  Google Scholar 

  • Trump BF, Berezesky IK (1987) Mechanisms of cell injury in the kidney:the role of calcium. In:Fowler BA (ed) Mechanisms of cell injury:implications for human health. Wiley, New York, pp 135–151

    Google Scholar 

  • Tsuchiya K (1978) Cadmium studies in Japan — a review. Kodansha, Tokyo — Elsevier/North-Holland Biomedical, New York

    Google Scholar 

  • Van der Velde WJ, Copius Peereboom-Stegeman JHJ, Treffers PE, James J (1983) Structural changes in the placenta of smoking mothers:a quantitative study. Placenta 4:231–240

    PubMed  Google Scholar 

  • Vallee BL, Ulmer DD (1972) Biochemical effects of mercury, cadmium and lead. Annu Rev Biochem 41:91–128

    PubMed  CAS  Google Scholar 

  • Vallee BL, Glades A (1974) The metallobiochemistry of zinc enzymes. Adv Enzymol 56:283–430

    Google Scholar 

  • Varga B, Paksy K (1991) Toxic effects of cadmium on LHRH-induced LH release and ovulation in rats. Reprod Toxicol 5:199–203

    PubMed  CAS  Google Scholar 

  • Varga B, Paksy K, Näray M (1991) Distribution of cadmium in ovaries, adrenals and pituitary gland after chronic administration in rats. Acta Physiol Hungarica 78:221–226

    CAS  Google Scholar 

  • Waalkes MP (1986) Effect of dietary zinc deficiency on the accumulation of cadmium and metallothionein in selected tissues of the rat. J Toxicol Environ Health 18:301–313

    PubMed  CAS  Google Scholar 

  • Waalkes MP, Goering PL (1990) Metallothionein and other cadmium-binding proteins:recent developments. Chem Res Toxicol 3:281–288

    PubMed  CAS  Google Scholar 

  • Waalkes MP, Oberdörster G (1990) Cadmium carcinogenesis. In: Foulkes EC (ed) Biological effects of heavy metals, vol II: metal carcinogenesis. CRC Press, Boca Raton, FL, pp 129–158

    Google Scholar 

  • Waalkes MP, Poirier LA (1984) In vitro cadmium-DNA interactions:cooperativity of cadmium binding and competitive antagonism by calcium, magnesium, and zinc. Toxicol Appl Pharmacol 75:539–546

    PubMed  CAS  Google Scholar 

  • Waalkes MP, Poirier LA (1985) Interactions of cadmium with interstitial tissue of the rat testes:uptake of cadmium by isolated interstitial cells. Biochem Pharmacol 34:2513–2518

    PubMed  CAS  Google Scholar 

  • Waalkes MP, Rehm S (1992) Carcinogenicity of oral cadmium in the male Wistar (WF/NCr) rat:effect of chronic dietary zinc deficiency. Fund Appl Toxicol 19:512–520

    CAS  Google Scholar 

  • Waalkes MP, Rehm S (1994) Chronic toxic and carcinogenic effects of cadmium in male DBA/2NCr and NFS/NCr mice:strain-dependent association with tumors of the hematopoietic system, injection site, liver and lung. Fund Appl Toxicol 23:21–31

    CAS  Google Scholar 

  • Waalkes MP, Poisner AM, Wood GW, Klaassen CD (1984) Metallothionein-like proteins in human placenta and fetal membranes. Toxicol Appl Pharmacol 74:179–184

    PubMed  CAS  Google Scholar 

  • Waalkes MP, Rehm S, Riggs CW, Bare RM, Devor DE, Poirier LA, Wenk ML, Henneman JR, Balaschak MS (1988a) Cadmium carcinogenesis in the male Wistar [Crl:(WI)BR] rats:dose-response analysis of tumor induction in the prostate and testes and at the injection site. Cancer Res 48:4656–4663

    PubMed  CAS  Google Scholar 

  • Waalkes MP, Ward JM, Konishi N (1988b) Toxicity and carcinogenicity of cadmium following repeated injections in rats:rapid induction of highly malignant tumors at the injection site. Proc Am Assoc Cancer Res 29:132

    Google Scholar 

  • Waalkes MP, Rehm S, Riggs CW, Bare RM, Devor DE, Poirier LA, Wenk ML, Henneman JR (1989) Cadmium carcinogenesis in the male Wistar [Crl:(WI)BR] rats:dose-response analysis of effects of zinc on tumor induction in the prostate, in the testes, and at the injection site. Cancer Res 49:4282–4288

    PubMed  CAS  Google Scholar 

  • Waalkes MP, Rehm S, Sass B, Konishi N, Ward JM (1991a) Chronic carcinogenic and toxic effects of a single subcutaneous dose of cadmium in the male Fischer rat. Environ Res 55:40–50

    PubMed  CAS  Google Scholar 

  • Waalkes MP, Kovatch R, Rehm S (1991b) Effect of chronic dietary zinc deficiency on cadmium toxicity and carcinogenesis in the male Wistar [Hsd:(WI)BR] rat. Toxicol Appl Pharmacol 108:448–456

    PubMed  CAS  Google Scholar 

  • Waalkes MP, Diwan BA, Bare RM, Ward JM, Weghorst C, Rice JM (1991c) Anticarcinogenic effects of cadmium in B6C3F1 mouse liver and lung. Toxicol Appl Pharmacol 110:327–335

    PubMed  CAS  Google Scholar 

  • Waalkes MP, Wahba ZZ, Rodriguez RE (1991d) Cadmium. In:Sullivan JB Jr, Krieger GR (eds) Hazardous materials toxicology. Williams and Wilkens, Baltimore, MD, pp 845–852

    Google Scholar 

  • Waalkes MP, Rehm S, Perantoni A, Coogan TP (1992a) Cadmium exposure in rats and tumors of the prostate. In:Nordberg GF, Alessio L, Herber RFM (eds) Cadmium in the human Environment:toxicity and carcinogenicity. IARC Scientific Publications, Lyon, France, pp 390–400

    Google Scholar 

  • Waalkes MP, Rehm S, Sass B, Ward JM (1992b) Induction of tumors of the hematopoietic system in rats. In:Nordberg GF, Alessio L, Herber RFM (eds) Cadmium in the human environment:toxicity and carcinogenicity. IARC Scientific Publications, Lyon, France, pp 401–404

    Google Scholar 

  • Waalkes MP, Coogan TP, Barter RA (1993a) Toxicological principles of metal carcinogenesis with special emphasis on cadmium. Crit Rev Toxicol 22:175–201

    Google Scholar 

  • Waalkes MP, Diwan BA, Weghorst CM, Ward JM, Rice JM, Cherian MG, Goyer RA (1993b) Further evidence of the tumor suppressive effects of cadmium in the B6C3F1 mouse liver and lung:late stage vulnerability of tumors to cadmium and the role of metallothionein. J Pharmacol Exper Therap 266:1656–1663

    CAS  Google Scholar 

  • Waalkes MP, Rehm S, Sass B, Kovatch R, Ward JM (1994) Chronic carcinogenic and toxic effects of a single subcutaneous dose of cadmium in male NFS and C57 mice and male Syrian hamsters. Toxic Sub J 13:15–28

    CAS  Google Scholar 

  • Wacker W, Vallee B (1959) Nucleic acids and metals. I. Chromium, manganese, nickel, iron and other metals in ribonucleic acid from diverse biological sources. J Biol Chem 234:3257–3262

    CAS  Google Scholar 

  • Wade GG, Mandel R, Ryser HJ-P (1987) Marked synergism of dimethylnitrosamine carcinogenesis in rats exposed to cadmium. Cancer Res 47:6606–6613

    PubMed  CAS  Google Scholar 

  • Wahba Z, Waalkes MP (1990) Effect of in vivo low-dose cadmium pre treatment on the in vitro interactions of cadmium with isolated interstitial cells of the rat testes. Fund Appl Toxicol 15:641–650

    CAS  Google Scholar 

  • Webb M (1979) The chemistry, biochemistry, and biology of cadmium. Elsevier/North-Holland Biomedical, NY

    Google Scholar 

  • Wisniewska-Knypl JM, Jablonska J, Myslak Z (1971) Binding of cadmium on metallothionein in man:an analysis of a fatal poisoning by cadmium chloride. Arch Toxicol 28:46–55

    CAS  Google Scholar 

  • Wong KL, Klaassen CD (1980) Age difference in the susceptibility to cadmium induced testicular damage in rats. Toxicol Appl Pharmacol 55:456–466

    PubMed  CAS  Google Scholar 

  • Yoshikawa H (1973) Preventive effects of pretreatment with cadmium on acute cadmium poisoning in rats. Ind Health 11:113–119

    CAS  Google Scholar 

  • Zavon MR, Meadow CD (1970) Vascular sequelae to cadmium fume exposure. Am Ind Hyg Assoc J 31:180–182

    PubMed  CAS  Google Scholar 

  • Zeng J, Heuchel R, Schaffner W, Kägi JHR (1991) Thionein (apometallothionein) can modulate DNA binding and transcription activation by zinc finger containing factor Spl. FEBS Lett 279:310–312

    PubMed  CAS  Google Scholar 

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  1. P. L. Goering
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  2. M. P. Waalkes
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  3. C. D. Klaassen
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Editors and Affiliations

  1. Department of Pathology, University of Western Ontario, N6A 5C1, Ontario, Canada

    Robert A. Goyer M.D. (Professor Emeritus) & M. George Cherian Ph.D. (Professor) (Professor Emeritus) &  (Professor)

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Goering, P.L., Waalkes, M.P., Klaassen, C.D. (1995). Toxicology of Cadmium. In: Goyer, R.A., Cherian, M.G. (eds) Toxicology of Metals. Handbook of Experimental Pharmacology, vol 115. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79162-8_9

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