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Chromium Toxicokinetics

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Toxicology of Metals

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 115))

Abstract

Chromium (Cr) toxicokinetics is the toxicokinetics of two different oxidation states, Cr(III) and Cr(VI), linked by reduction processes that are ubiquitous in body fluids and tissues. The kinetic behaviors of these two major oxidation states of chromium are very different. Reduction of Cr(VI) to Cr(III) in the body, the lung, and the gastrointestinal tract is sufficiently rapid that bulk chromium kinetics may be considered to be the kinetics of Cr(III). However, certain detectable differences in chromium disposition depend upon whether exposure is to a Cr(III) or a Cr(VI) salt. In addition, the reduction process itself is of interest relative to the carcinogenicity of Cr(VI) in the lung. Therefore, a comprehensive understanding of the toxicokinetics of chromium must include the disposition of both Cr(III) and Cr(VI).

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Authors
  1. E. J. O’Flaherty
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Editors and Affiliations

  1. Department of Pathology, University of Western Ontario, N6A 5C1, Ontario, Canada

    Robert A. Goyer M.D. (Professor Emeritus) & M. George Cherian Ph.D. (Professor) (Professor Emeritus) &  (Professor)

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© 1995 Springer-Verlag Berlin Heidelberg

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O’Flaherty, E.J. (1995). Chromium Toxicokinetics. In: Goyer, R.A., Cherian, M.G. (eds) Toxicology of Metals. Handbook of Experimental Pharmacology, vol 115. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79162-8_10

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  • DOI: https://doi.org/10.1007/978-3-642-79162-8_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79164-2

  • Online ISBN: 978-3-642-79162-8

  • eBook Packages: Springer Book Archive

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