Abstract
The recognition that we may be approaching a plateau of effectiveness with traditional anticancer agents has led to the view that to gain more than incremental value against the major solid tumours will require a radically different strategy. Rather than the “black box” approach of random screening for cytotoxicity or cytostasis, or even the rational design of improved agents acting on conventional drug targets [1,2], many believe that this quantum leap will come from an exploitation of the identification of the genes and their encoded protein products which control proliferation, differentiation and cell death, combined with an understanding of their aberrant behaviour in malignant cells. Cancer is now described in extraordinary detail at the molecular level as a genetic disease. As a result of the remarkable advances in molecular oncology made over the last few years, the new central dogma of cancer drug discovery can be defined as: new biology → new targets → new therapies [3].
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Workman, P., Brunton, V.G., Robins, D.J. (1994). Discovery and Design of Inhibitors of Oncogenic Tyrosine Kinases. In: Workman, P., D’lncalci, M. (eds) New Approaches in Cancer Pharmacology: Drug Design and Development. ESO Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79088-1_6
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