Abstract
Once inhaled a particle interacts at various stages, during its path in the respiratory tract, with cells, tissues and biological fluids. Each contact involves a specific functionality at the particle surface, so that the chemical features determining the overall pathogenicity of a given dust are probably more than one. Modulation of one surface property may thus end up in variation of the ultimate toxicity caused even by active surface sites which are unchanged. For this reason investigations on all surface properties of a toxic dust are required.
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References
Absher M.P., Trombley, L. Hemenway D.R. Mickey R.M., Leslie K.CX (1989) Biphasic cellular and tissue response of rat lungs after eight–day aerosol exposure to the silicon dioxide cristobalite. Am. J. Pathol,. 134,: 1243–1251.
Bégin R, Dufresne A, Cantin A, Massé S, Sebastien P., Perrault G. (1989) Carborundum pneumoconiosis. Fibres in in the mineral activate macrophages to produce fibroblast growth factors and sustain the chronic inflammatory disease. Chest, 95: 842–849.
Birchall J.D., Stanley D.R., Mockford M.J., Pigott G.H., Pinto P.J. (1988) Toxicity of silicon carbide whiskers, J. Mat. Sci. Lett,. 7: 350–352.
Bolis V., Fubini B., Garrone E., Morterra C. (1989) Thermodynamic and vibrational characterisation of CO adsorption on variously pretreated anatase. J. Chem. Soc. Faraday, Trans, I, 85
Bolis V., Fubini B., Marchese L., Martra G., Costa D. (1991) Hydrophilic and hydrophobic sites on dehydrated crystalline and amorphous silicas. J. Chem. Soc. Faraday, Tram., 87: 497–505.
Dufresne A., Perrault G., Sebastien P., Adnot A., Baril M. (1987) Morphology and surface characteristics of particulate from silicon carbide industries Am. Ind. Ass. J., 48: 718 –729.
Dzwigaj S., Pezerat H., Wastiaux A., Sebastien P., and Honnons S. (1993) Silica and silicosis mechanism. The role of surface properties of particles and of the silica–supported iron. Proceedings of the Eight International Conference on Occupational Lung Diseases
Hurich et al. ed., ILO, Geneva, CH, p.1186–1191. Fubini B., Giamello E., Pugliese L., Volante M. (1989). Mechanically induced defects in quartz and their impact on pathogenicity. Solid State Ionics, 32–33: 334–343.
Fubini B.,Giamello E., Volante M., and Bolis V. (1990). Chemical functionalities at the silica surface determining its reactivity when inhaled. Formation and reactivity of surface radicals. Toxicology and Industrial Health,, 6: 571–594.
Fubini B., Bolis V., Giamello E. and Volante M. (1991) Chemical functionalities at the broken fibre surface relatable to free radicals production in “Mechanisms in Fibre, Carcinogenesis”, (R.C. Brown, J.A. Hoskins, N.F. Johnson, eds.) NATO ASI series, Plenum press, New York, p. 415–432.
Fubini B. Bolis V., Cavenago A. and Ugliengo P. (1992) Ammonia and water as probes for the surface re reactivity of covalent solids: the case of cristobalite and silicon carbide. J.Chem.Soc. Faraday Trans., 88: 277–290.
Fubini B., Volante M., Giamello E., Bolis V. (1993) The role of surface chemistry in the pathogenicity of mineral dusts and fibres: some open questions; in “Proceedings of the Eighth International Conference on Occupational Lung Diseases”, J.Hurich,M.Leasage, and A.David eds., ILO, Geneva, Switzerland, Vol. Ill, p. 1180–1185.
Fubini B. (1993) The possible role of surface chemistry in the toxicity of inhaled fibers in “Fiber Toxicology”, D.B.Warheit ed., Academic Press, Chapter 11, p.229–257.85)
Funahashi A., Schlneter O.P., Pintar K., Siegesmund K.A., Mandel G.S., Mandel N.S. (1984) Pneumoconiosis in workers exposed to Silicon Carbide., Am. rev. Respir. Dis,. 129 (4): 635–640.
Giamello E., Fubini B., Volante M., Costa D. Surface oxygen radicals originating via redox reactions during the mechanical activation of crystalline Si02 in hydrogengen peroxide Colloids and Surfaces,, 45, 155–165, (1990).
Goodlick L.A., Kane A.B. (1986) Role of reactive oxygen metabolites in crocidolite asbestos toxicity to mouse macrophages. Cancer Res,. 46: 5558–5566.
Gulumian M, Van Wyk J. A. (1987) Hydroxyl radical production in the presence of fibres by a Fenton–type reaction. Chem. Biol. Interactions,, 62: 89–97
Hemenway D.R., Absher M.P., Trombley L., Vacek P.M. (1990) Comparative clearance of quartz and cristobalite from the lung. Am. Ind.Hyg.Assoc,. 51 (7): 363–369.
Hemenway D.R., Absher M.P, Fubini B and Bolis V. (1993a) What is the Relationship between Hemolytic Potential and Fibrogenicity of Mineral Dusts? Arch.Environ.Health
Hemenway D.R., Absher M.P., Fubini B., Trombley L., Vacek P. Volante M., Cavenago A. Surface functionalities are related to biological response and transport of crystalline silica. 7th Intern. Symposium on Inhaled Particles BOHS, Edinburgh, 1991, Ann Occup.Hyg., in press.
Honnons S., Oberson D., Wastiaux A., Dz Dzwigaj S., Pezerat H., Volante M., Fubini B., Porcher J.M. Pulmonary response to silica dust: the influence of crystalline structures and physico–chemical properties. Second International Symposium on Silica Silicosis and Cancer, San Francisco, October 1993
Leanderson P, Soderkvist, Tagesson C, Axelson O (1988) Formation of 8– hydroxydeoxyguanosine by asbestos and man–made mineral fibers. Br. J. Ind. Med., 45: 309–311.
Lund L.G. Aust A.E. (1990) Iron mobilization from asbestos by chelators and ascorbic acid. Arch Biochem.Biophys., 278: 60–64. (1991a) Mobilization of iron from crocidolite asbestos by certain chelators results in enhanced crocidolite–dependent oxygen consumption. Arch Biochem.Biophys., 287: 91–96. (1991b)
Iron catalyzed reactions may be responsible for the biochemical and biological effects of asbestos. Bk\factors, 3:83–89.
Mossman B.T., Marsh J.P., Shatos M.A. (1986) Alteration of superoxide dismutase activity in tracheal epithelial cells by asbestos and inhibition of cytotoxicity by antioxidants. Lab, Invest., 54: 204–212.
Oberdoster G., Ferin J., Soderholm S., Gelein R., Cox C., Baggs R. Morrow P.E. 7th Intern. Symposium on Inhaled Particles BOHS, Edinburgh, 1991, Ann Occup. Hyg., in press.
Vallyathan,V., Shi, X., Dalai, N.S., Irr, W. and Castranova, V. (1988) Generation of free radicals from freshly fractured silica dust: potential role in acute silica–induced lung injury. Am. Rev. Respir. Dir,. 138, 1213–1219.
Wastiaux A., Erre R., Pezerat H., Sebastien P. Quartz surface and fibrogenicity. 7th Intern. Symposium on Inhaled Particles BOHS, Edinburgh, 1991, Ann Occup. Hyg., in press.
Wiecek E. The influence of real structure of quartz and cristobalite on their fibrogenic effects. Second International Symposium on Silica Silicosis and Cancer, San Francisco, October 1993
Zalma R., Bonneau L., Jaurand M.C., Guignard J. and Pezerat H. (1987) Formation of oxyradicals by oxygen reduction arising from the surface activity of asbestos. Can. J. Chem,. 652, 338–2341.
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Fubini, B. (1994). Which Surface Functionalities are implied in Dust Toxicity?. In: Davis, J.M.G., Jaurand, MC. (eds) Cellular and Molecular Effects of Mineral and Synthetic Dusts and Fibres. NATO ASI Series, vol 85. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79041-6_35
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DOI: https://doi.org/10.1007/978-3-642-79041-6_35
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