Abstract
G-protein-linked signal transduction pathways play essential roles during the differentiation process of Dictyostelium discoideum, a simple developing eucaryotic organism. These transmembrane signaling systems are essentially the same as those in mammalian cells, and there are simple methods to disrupt genes by homologous recombination and to create cell lines expressing mutant genes. In addition, Dictyostelium is easy to grow, and development is synchronous, allowing one to readily obtain 1011 cells for biochemical studies. Thus, Dictyostelium provides a model system to study G-protein-linked signal transduction.
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Wu, L. et al. (1993). Signal Transduction by G-Proteins in Dictyostelium discoideum . In: Dickey, B.F., Birnbaumer, L. (eds) GTPases in Biology II. Handbook of Experimental Pharmacology, vol 108 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78345-6_21
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DOI: https://doi.org/10.1007/978-3-642-78345-6_21
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