Abstract
The study of proto-oncogenes has been responsible for the elucidation of a wide range of genes that encode proteins with functions that are critical in regulating cell growth and development. Although the number of proto-oncogenes is large there presently appears to be only three biochemical mechanisms by which these genes act (Bishop, 1991). These are the phosphorylation of proteins with serine, threonine and tyrosine as substrates, the transmission of signals by GTPases and the regulation of gene transcription. However, the functions of some oncogenes remain unknown and as such it is possible that this list of mechanisms may be expanded in the future.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bishop MJ (1991) Molecular themes in oncogenesis. Cell 64:235–248.
Blake TJ, Shapiro M, Morse HC, Langdon WY (1991) The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif. Oncogene 6:653–657.
Blake TJ, Langdon WY (1992) A rearrangement of the c-cbl proto-oncogene in HUT78 T lymphoma cells results in a truncated protein. Oncogene 7 (in press).
Henkel T, Zabel U, van Zee K, Muller JM, Fanning E, Baeverle PA (1992) Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-κB subunit. Cell 68:1121–1133.
Langdon WY, Hartley JW, klinken SP, Ruscetti Sk, Morse HC (1989) v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas. Proc Natl Acad Sci. USA 86:1168–1172.
Smith DB, Johnson KS (1988) Single-step purification of Polypeptides expressed in Escherichia coli as fusions with glutathione-S-transferase. Gene 67:31–40.
Silver PA (1991) How proteins enter the nucleus. Cell 64:489–497.
Zelligs JD, Wollman SH (1979) Mitosis in rat thyroid epithelial cells in vivo. Ultrastructural changes in cytoplasmic organelles during the mitotic cycle. J Ultrastruct Res 66:53–77.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Langdon, W.Y., Heath, K.G., Blake, T.J. (1992). The Localization of the Products of the c-cbl and v-cbl Oncogenes During Mitosis and Transformation. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1992. Current Topics in Microbiology and Immunology, vol 182. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77633-5_59
Download citation
DOI: https://doi.org/10.1007/978-3-642-77633-5_59
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-77635-9
Online ISBN: 978-3-642-77633-5
eBook Packages: Springer Book Archive