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AIDS Associated Non-Hodgkin’s Lymphomas Represent a Broad Spectrum of Monoclonal and Polyclonal Lymphoproliferative Processes

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Mechanisms in B-Cell Neoplasia 1992

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 182))

Abstract

Lymphoma is a devastating complication of HIV disease occurring at an incidence of approximately 5–15% in AIDS patients, at a 25–100 fold increase as related to the non-HIV-infected population [1–3]. Initial studies emphasized the B-cell nature of these neoplasms analogous, except for the high incidence of Burkitt’s lymphoma, to the lymphomas arising in transplant patients [4–6] and patients with congenital immunodeficiencies [7–9]. Previous genotypic surveys of the HIV associated lymphomas found similarities to transplant lymphomas (a subset of transplant “lymphomas” are polyclonal and associated with the EBV) and Burkitt’s lymphomas (genotypic analysis of Burkitt’s lymphomas reveals chromosomal translocations near immunoglobulin (Ig) gene loci and the proto-oncogene c-myc) [10, 11]. More recently, phenotypic analysis was initiated to verify the B-cell nature of the neoplasms and this analysis was further expanded to explore the exact cellular milieu of the lymphomas associated with HIV infection [12].

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Authors and Affiliations

  1. Departments of Pathology, Pediatrics, Laboratory Medicine, and Medicine, University of California, San Francisco General Hospital, 1001 Potrero Avenue, San Francisco, CA, 94110, USA

    B. G. Herndier, B. T. Shiramizu & M. S. McGrath

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  1. B. G. Herndier
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  2. B. T. Shiramizu
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  3. M. S. McGrath
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Editors and Affiliations

  1. Laboratory of Genetics, National Cancer Institute National Institutes of Health, Bldg. 37, Rm 2B04, Bethesda, MD, 20892, USA

    Michael Potter M. D (Chief) (Chief)

  2. Institute for Immunology, Grenzacherstr. 487, CH-4005, Basel, Switzerland

    Fritz Melchers (Director) (Director)

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© 1992 Springer-Verlag Berlin Heidelberg

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Herndier, B.G., Shiramizu, B.T., McGrath, M.S. (1992). AIDS Associated Non-Hodgkin’s Lymphomas Represent a Broad Spectrum of Monoclonal and Polyclonal Lymphoproliferative Processes. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1992. Current Topics in Microbiology and Immunology, vol 182. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77633-5_49

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  • DOI: https://doi.org/10.1007/978-3-642-77633-5_49

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77635-9

  • Online ISBN: 978-3-642-77633-5

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