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The Role of Cytokine Networks Mediating Inflammation and Ischemia-Reperfusion Injury

  • Conference paper
Shock, Sepsis, and Organ Failure

Abstract

Acute inflammation constitutes the host’s response to a variety of insults, including infection, multiorgan failure associated with sepsis, cancer, trauma, shock, allograft rejection, and ischemia-reperfusion injury. The salient inflammatory reaction that accompanies these states is often related to severe microvascular injury. The consequence of this vascular injury is diffuse endothelial cell damage resulting in 1) increased vascular permeability and extravascular fluid accumulation, 2) enhanced activation of the intrinsic and extrinsic coagulation pathways and inhibition of plasminogen activation favoring a procoagulant state, 3) release of reactive oxygen metabolites, cytokines, vasoactive mediators including kinins, 4) arachidonate metabolites, culminating in augmented intravascular aggregation and transendothelial leukocyte emigration. Although, the principal leukocyte effector cell associated with the above conditions is the neutrophil, other immune and non-immune cells can become active participants in the inflammatory responses. Thus humoral mediators leading to interactions between immune and non-immune cells are important to the full development of the pathogenesis of the acute inflammatory response. In this chapter, we will focus our attention on mediators of inflammation that are potentially critical to the inflammatory response associated with ischemia-reperfusion injury.

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Authors and Affiliations

  1. Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, The University of Michigan Medical School, Ann Arbor, Michigan, 48109-0360, USA

    Robert M. Strieter, Mark W. Rolfe & Theodore J. Standiford

  2. Department of Pediatrics, Division of Pulmonary and Critical Care Medicine, The University of Michigan Medical School, Ann Arbor, Michigan, 48109-0360, USA

    Andrew P. Metinko & Steven R. DeMeester

  3. Department of Surgery, Division of Pulmonary and Critical Care Medicine, The University of Michigan Medical School, Ann Arbor, Michigan, 48109-0360, USA

    Lisa M. Colletti

  4. Department of Pathology, Division of Pulmonary and Critical Care Medicine, The University of Michigan Medical School, Ann Arbor, Michigan, 48109-0360, USA

    Steven L. Kunkel

Authors
  1. Robert M. Strieter
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  2. Lisa M. Colletti
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  4. Mark W. Rolfe
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  6. Theodore J. Standiford
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  7. Steven L. Kunkel
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Editor information

Editors and Affiliations

  1. Ludwig-Boltzmann-Institute for Experimental and Clinical Traumatology, DonaueschingenstraĂŸe 13, A - 1200, Vienna, Austria

    GĂ¼nther Schlag M. D.  & Heinz Redl Ph. D.  & 

  2. Department of Anesthesia, University of Texas, Med. Branch 610 Texas Avenue, Galveston, TX, 77550-1091, USA

    Daniel Traber Ph. D.

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© 1993 Springer-Verlag Berlin Heidelberg

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Strieter, R.M. et al. (1993). The Role of Cytokine Networks Mediating Inflammation and Ischemia-Reperfusion Injury. In: Schlag, G., Redl, H., Traber, D. (eds) Shock, Sepsis, and Organ Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77420-1_8

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  • DOI: https://doi.org/10.1007/978-3-642-77420-1_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-55339-7

  • Online ISBN: 978-3-642-77420-1

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