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Volume Regulation in Transporting Epithelia

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Advances in Comparative and Environmental Physiology

Part of the book series: Advances in Comparative and Environmental Physiology ((COMPARATIVE,volume 14))

Abstract

The cell volume is regulated by solute transport across the surface membranes and by metabolic generation or consumption of intracellular, osmotically active solutes. Many membrane transport mechanisms and metabolic pathways that are involved in volume regulation serve other vital cell functions also, including the control of the intracellular milieu (electrolyte concentrations, cell pH), energy, carbohydrate and protein metabolism, nutritive and secretory functions, excitability, cell growth, proliferation and differentiation. Cell volume regulation is thus integrally related to these functions. Furthermore, the mechanisms of homeostatic control and regulation through hormonal, neural and intracellular signals may modify membrane transport mechanisms and enzyme activities that are involved in volume regulation. Thus, both the mechanisms that determine the cell volume and their regulatory signals may be common to other cell functions.

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Authors and Affiliations

  1. Department of General and Experimental Pathology, University Hospital, Währinger Gurtel 18-20, 1090, Vienna, Austria

    J. Graf

  2. Department of Physiology, School of Medicine, The Johns Hopkins University, 725 N. Wolfe Street, Baltimore, Maryland, 21205, USA

    W. B. Guggino

  3. Pharmakologisches Institut, Universität Wien, Währingerstraße 13a, 1090, Vienna, Austria

    K. Turnheim

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  1. J. Graf
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  2. W. B. Guggino
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  3. K. Turnheim
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  1. Physiologisches Institut, Universität Tübingen, Gmelinstraße 5, W-7400, Tübingen, Germany

    Florian Lang

  2. Abteilung für Innere Medizin, Universität Freiburg, Hugstetterstraße 55, W-7800, Freiburg, Germany

    Dieter Häussinger

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Graf, J., Guggino, W.B., Turnheim, K. (1993). Volume Regulation in Transporting Epithelia. In: Lang, F., Häussinger, D. (eds) Advances in Comparative and Environmental Physiology. Advances in Comparative and Environmental Physiology, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77124-8_3

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