Abstract
The molecular biology of measles virus (MV) and of other nonsegmented negative strand RNA viruses is currently subject to intense scrutiny for several reasons. First, acute MV infection is among the primary causes of infant death in third world countries (Bloom 1989). Second, on rare occasions, MV persistence induces lethal syndromes of the central nervous system known as subacute sclerosing panencephalitis (SSPE) and measles inclusion body encephalitis (MIBE) (reviewed in Ter Meulen et al. 1983). Third, unexpected phenomena such as biased hypermutation and RNA editing recently have been described for these viruses (reviewed in Billeter and Cattaneo 1991; Cattaneo 1990).
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References
Ayata M, Hirano A, Wong TC (1989) Structural defect linked to nonrandom mutations in the matrix gene of Biken strain subacute sclerosing panencephalitis virus defined by cDNA cloning and expression of chimeric genes. J Virol 63: 1162–1173
Baczko K, Liebert UG, Billeter M, Cattaneo R, Budka H, ter Meulen V (1986) Expression of defective measles virus genes in brain tissues of patients with subacute sclerosing panencephalitis. J Virol 59: 472–478
Bass BL, Weintraub H (1988) An unwinding activity that covalently modifies its double-stranded RNA substrate. Cell 55: 1089–1098
Bass BL, Weintraub H, Cattaneo R, Billeter MA (1989) Biased hypermutation of viral RNA genomes could be due to unwinding/modification of double-stranded RNA. Cell 56: 331
Billeter MA, Cattaneo R (1991) Molecular biology of defective measles viruses persisting in the human central nervous system. In: Kingsbury DW (Ed) The paramyxoviruses. Plenum, New York, pp 323–345
Bloom BR (1989) Vaccines for the Third World. Nature 342: 115–120
Buckland R, Giraudon P, Wild F (1989) Expression of measles virus nucleoprotein in Escherichia coli: use of deletion mutants to locate the antigenic sites. J Gen Virol 70: 435–441
Cattaneo R (1990) Messenger RNA editing and the genetic code. Experientia 46: 1142–1148
Cattaneo R, Schmid A, Rebmann G, Baczko K, ter Meulen V, Bellini WJ, Rozenblatt S, Billeter MA (1986) Accumulated measles virus mutations in a case of subacute sclerosing panencephalitis: interrupted matrix protein reading frame and transcription alteration. Virology 154: 97–107
Cattaneo R, Rebmann G, Schmid A, Baczko K, ter Meulen V, Billeter MA (1987a) Altered transcription of a defective measles virus genome derived from a diseased human brain. EMBO J 6: 681–688
Cattaneo R, Rebmann G, Baczko K, ter Meulen V, Billeter MA (1987b) Altered ratios of measles virus transcripts in diseased human brains. Virology 160: 523–526
Cattaneo R, Schmid A, Eschle D, Baczko K, ter Meulen V, Billeter MA (1988) Biased hypermutation and other genetic changes in defective measles viruses in human brain infections. Cell 55: 255–265
Cattaneo R, Kaelin K, Baczko K, Billeter MA (1989a) Measles virus editing provides an additional cysteine-rich protein. Cell 56: 759–764
Cattaneo R, Schmid A, Spielhofer P, Kaelin K, Baczko K, ter Meulen V, Pardowitz J, Flanagan S, Rima BK, Udem SA, Billeter MA (1989b) Mutated and hypermutated genes of persistent measles viruses which caused lethal human brain diseases. Virology 173: 415–425
Chattopadhyay D, Banerjee AK (1988) NH2-terminal acidic region of the phosphoprotein of vesicular stomatitis virus can be functionally replaced by tubulin. Proc Natl Acad Sci USA 85: 7977–7981
Enami M, Sato TA, Sugiura A (1989) Matrix protein of cell-associated subacute sclerosing panencephalitis viruses. J Gen Virol 70: 2191–2196
Hall WW, Lamb RA, Choppin PW (1979) Measles and subacute sclerosing panencephalitis virus proteins: lack of antibodies to the M protein in patients with subacute sclerosing panencephalitis. Proc Natl Acad Sci USA 76: 2047–2051
Holland J, Spindler K, Horodyski F, Grabau E, Nichol S, Van de Pol S (1982) Rapid evolution of RNA genomes. Science 215: 1577–1585
Kaelin K (1989) RNA editing in the measles virus phosphoprotein gene provides an additional protein. Diploma thesis, University of Zurich
Kimelman D, Kirschner MW (1989) An antisense mRNA directs the covalent modification of the transcript encoding fibroblast growth factor in Xenopus oocytes. Cell 59: 687–696
Kristensson K, Norrby E (1986) Persistence of RNA viruses in the central nervous system. Annu Rev Microbiol 40: 159–184
Masters PS, Banerjee AK (1987) Sequences of Chandipura virus N and NS genes: evidence for high mutability of the NS gene within vesiculoviruses. Virology 157: 298–306
Murphy DG, Dimock K, Kang CY (1991) Numerous transitions in human parainfluenza virus 3 RNA recovered from persistently infected cells. Virology 181: 760–763
Norrby E, Kristensson K, Brzosko WJ, Kapsenberg JG (1985) Measles virus matrix protein detected by immune fluorescence with monoclonal antibodies in the brain of patients with subacute sclerosing panencephalitis. J Virol 56: 337–340
O’Hara PJ, Nichol ST, Horodyski FM, Holland JJ (1984) Vesicular stomatitis virus defective interfering particles can contain extensive genomic sequence rearrangements and base substitutions. Cell 36: 915–924
Pathak VK, Temin HM (1990) Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: substitutions, frameshifts and hypermutations. Proc Natl Acad Sci USA 87: 6019–6023
Rima BK (1989) Comparison of amino acid sequences of the major structural proteins of the paramyxo and morbilliviruses. In: Mahy BWJ, Kolakofsky E (Eds.) Genetics and pathogenicity of negative strand viruses. Elsevier, Amsterdam, pp 254–263
Rowlands D, Grabau E, Spindler K, Jones C, Semler B, Holland J (1980) Virus protein changes and RNA termini alterations evolving during persistent infection. Cell 19: 871–880
Schneider-Schaulies S, Liebert UG, Baczko K, Cattaneo R, Billeter M, ter Meulen V (1989) Restriction of measles virus gene expression in acute and subacute encephalitis of Lewis rats. Virology 171: 525–534
Steinhauer DA, Holland JJ (1987) Rapid evolution of RNA viruses. Annu Rev Microbiol 41: 409–433
Taylor MJ, Godfrey E, Baczko K, ter Meulen V, Wild TF, Rima BK (1991) Identification of several different lineages of measles virus. J Gen Virol 72: 83–88
Ter Meulen V, Stephenson JR, Kreth HW (1983) Subacute sclerosing panencephalitis. Compr Virol 18: 105–159
Thomas SM, Lamb RA, Paterson RG (1988) Two mRNAs that differ by two nontemplated nucleotides encode the amino coterminal proteins P and V of the paramyxovirus SV5. Cell 54: 891–902
Vartanian J-P, Meyerhans A, Asiö B, Wain-Hobson S (1991) Selection, recombination and G/A hypermutation of human immunodeficiency virus type I genomes. J Virol 65: 1779–1788
Wagner RW, Yoo C, Wrabetz L, Kamholz J, Buchhalter J, Hassan NF, Khalili K, Kim SU, Perussia B, McMorris FA, Nishikura K (1990) Double-stranded RNA unwinding and modifying activity is detected ubiquitously in primary tissues and cell lines. Mol Cell Biol 10: 5586–5590
Wechsler SL, Fields BN (1978) Differences between the intracellular polypeptides of measles and subacute sclerosing panencephalitis virus. Nature 272: 458–460
Wechsler SL, Meissner HC (1982) Measles and SSPE viruses: similarities and differences. Prog Med Virol 28: 65–95
Whitt MA, Chong L, Rose JK (1989) Glycoprotein cytoplasmic domain sequences required for rescue of a vesicular stomatitis virus glycoprotein mutant. J Virol 63: 3569–3578
Wild TF, Malvoisin E, Buckland R (1991) Measles virus: both the haemagglutinin and fusion glycoproteins are required for fusion. J Gen Virol 72: 439–442
Wong TC, Ayata M, Hirano A, Yoshikawa Y, Tsuruoka H, Yamanouchi K (1989) Generalized and localized biased hypermutation affecting the matrix gene of a measles virus strain that causes subacute sclerosing panencephalitis. J Virol 63: 5464–5468
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© 1992 Springer-Verlag Berlin · Heidelberg
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Cattaneo, R., Billeter, M.A. (1992). Mutations and A/I Hypermutations in Measles Virus Persistent Infections. In: Holland, J.J. (eds) Genetic Diversity of RNA Viruses. Current Topics in Microbiology and Immunology, vol 176. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77011-1_5
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DOI: https://doi.org/10.1007/978-3-642-77011-1_5
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