Skip to main content

A Simulation of the Humoral Immune System

  • Conference paper
Theoretical and Experimental Insights into Immunology

Part of the book series: NATO ASI Series ((ASIH,volume 66))

Abstract

The idea of theoretically describing the immune system has become popular in the past decade, and in fact the existence of the present volume is evidence for the emergence of the field. With the advent of modern high-speed computers it no longer seems impossible to model and simulate the behavior of the immune system. Previous attempts at modeling the immune system have generally followed the course of focussing on a phenomenon or class of phenomena, writing down the differential equations for these phenomena and then trying to obtain solutions (Perelson 1988, 1990). This approach has led to better understanding of the phenomena and how they might be applied to the immune system, but often the mathematical approximations required to obtain solutions have removed much of the connection with the actual biological system, or at least made the connections much more opaque.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bell GI (1970) Mathematical model of clonal selection and antibody production. Nature 228: 739–744

    Article  PubMed  CAS  Google Scholar 

  • Celada F, Seiden PE (to be published) A computer model of cellular interactions in the immune system. Immun. Today

    Google Scholar 

  • Chowdhury D, Stauffer D (1990) Systematics of the models of immune response and autoimmune disease. J Stat Phys 59: 1019–1042

    Article  Google Scholar 

  • Farmer JD, Packard NH, Perelson AS (1986) The immune system, adaptation, and machine learning. Physica 22D: 187–204

    Google Scholar 

  • Jerne N (1974) Towards a network theory of the immune system. Ann. Inst. Pasteur Immunol. 125C: 435–441

    Google Scholar 

  • Kaufman M, Urbain J, Thomas R (1985) Towards a logical analysis of the immune response. J Theor Biol 114: 527–561

    Article  PubMed  CAS  Google Scholar 

  • Neumann AU (1989) Control of the immune response by a threshold automata model on a lattice. Physica A 162: 1–19

    Article  Google Scholar 

  • Perelson, AS (ed) (1988) Theoretical immunology. Addison-Wesley, Redwood City

    Google Scholar 

  • Perelson, AS (1989) Immune network theory. Immunol. Rev. 110: 5–36

    Article  PubMed  CAS  Google Scholar 

  • Perelson, AS (1990) Theoretical immunology. In: Jen E (ed) 1989 Lectures in Complex Systems, SFI Studies in the Sciences of Complexity, vol. II. Addison-Wesley, Redwood City, p 465

    Google Scholar 

  • Seiden PE, Celada F (submitted) A model for simulating cognate recognition and response in the immune system. J Theor Biol

    Google Scholar 

  • Varela FJ, Coutinho A (1991) Second generation immune networks. Immunol. Today 12: 159–166

    PubMed  CAS  Google Scholar 

  • Weisbuch G, Atlan H (1988) Control of the immune response. J Phys A 21: L189–192

    Article  Google Scholar 

  • Wolfram S (1984) Preface to Cellular Automata. Physica 10D:vii–xii

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Seiden, P.E., Celada, F. (1992). A Simulation of the Humoral Immune System. In: Perelson, A.S., Weisbuch, G. (eds) Theoretical and Experimental Insights into Immunology. NATO ASI Series, vol 66. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76977-1_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-76977-1_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76979-5

  • Online ISBN: 978-3-642-76977-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics