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Relationship Between Oxygen Demand and Oxygen Supply in Severe Sepsis

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Pathophysiology of Shock, Sepsis, and Organ Failure

Abstract

Severe sepsis is characterized by an increase in oxygen demand, which is related to the inflammatory response to severe infection or other types of serious injury. This inflammatory process is simultaneously responsible for the peripheral alterations associated with sepsis. The pathophysiology of the alterations in systemic oxygen extraction is complex and can include: (a) microvascular obstruction by the activated cellular elements, (b) the release of various circulating mediators, and (c) alterations in endothelial cells resulting in a reduction in arteriolar tone, an abnormal distribution of blood flow, and the formation of peripheral edema that may compress the microvasculature and increase the diffusion gradient for oxygen from the capillaries to the mitochondria.

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Authors and Affiliations

  1. Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    J.-L. Vincent, J. Bakker & P.-G. Silance

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  1. J.-L. Vincent
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  2. J. Bakker
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  3. P.-G. Silance
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Editors and Affiliations

  1. Ludwig-Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingenstraße 13, A-1200, Vienna, Austria

    Günther Schlag M. D.  & Heinz Redl Ph. D.  & 

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Vincent, JL., Bakker, J., Silance, PG. (1993). Relationship Between Oxygen Demand and Oxygen Supply in Severe Sepsis. In: Schlag, G., Redl, H. (eds) Pathophysiology of Shock, Sepsis, and Organ Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76736-4_61

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  • DOI: https://doi.org/10.1007/978-3-642-76736-4_61

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76738-8

  • Online ISBN: 978-3-642-76736-4

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