Abstract
A number of genetic disorders manifesting widely different clinical symptoms predispose the affected individual to a high risk of cancer. These include, among others, ataxia telangiectasia, Bloom’s syndrome, familial polyposis, Fanconi’s anemia, Gardner’s syndrome, and xeroderma pigmentosum (Setlow 1978). We have shown that skin fibroblasts from affected individuals or individuals with a family history of cancer, compared to cells from clinically normal controls, with few exceptions, show a significantly higher frequency of chromatid breaks and gaps following X-irradiation during the G2 cell cycle phase (Parshad et al. 1983, 1985a; Sanford et al. 1989). Furthermore, it appears that this enhanced chromatid damage results from deficient DNA repair during G2 phase (Parshad et al. 1983, 1985b; Gantt et al. 1986, 1989), that it has a genetic basis (Sanford et al. 1986), and that it is associated with genetic susceptibility to cancer (Gantt et al. 1989; Sanford et al. 1989).
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© 1990 Springer-Verlag Berlin Heidelberg
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Sanford, K.K., Parshad, R. (1990). Detection of Cancer-Prone Individuals Using Cytogenetic Response to X-Rays. In: Obe, G., Natarajan, A.T. (eds) Chromosomal Aberrations. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75682-5_12
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DOI: https://doi.org/10.1007/978-3-642-75682-5_12
Publisher Name: Springer, Berlin, Heidelberg
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