Abstract
A peripheral nerve injury leads to a number of changes in the metabolism of the injured neurons and of the non-neuronal cells surrounding their axons. Some of these changes are directly related to the trauma itself and occur rapidly in the non-neuronal cells close to the site of injury; others are characteristic of neurons which depend on a proper interaction with their target for their normal function. Thus, a nerve transection interrupts the axoplasmic transport which carries molecular information from the periphery to the centrally located neuronal cell body and can result in nerve atrophy and ultimately in death of specific populations of neurons. In this context, neurotrophic factors providing trophic support play an essential role in counteracting the deleterious effects of the nerve injury.
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© 1990 Springer-Verlag Berlin Heidelberg
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Lindholm, D., Thoenen, H. (1990). Role of Neurotrophic Factors in Peripheral Nerve Regeneration. In: Samii, M. (eds) Peripheral Nerve Lesions. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75611-5_5
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DOI: https://doi.org/10.1007/978-3-642-75611-5_5
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