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Germinal Center Reaction and B Lymphocytes: Morphology and Function

  • Chapter
Reaction Patterns of the Lymph Node

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 84/1))

Abstract

In peripheral lymphoid organs, B and T cells are predominantly, but not exclusively, located in different anatomical compartments: B cells are mainly observed in lymphoid follicles, whereas T cells constitute the so-called paracortical areas and interfollicular areas (e.g., lymph node and tonsil) or periarteriolar lymphocyte sheath (PALS) (spleen). In the spleen, but not in other lymphoid organs, an additional B-cell compartment associated with B-cell follicles can be found, i.e., the marginal zone. Marginal zone B cells are different from follicular B cells in several ways (e.g., phenotype, function, development), and it has been speculated that these B cells represent a distinct B-cell lineage (MacLennan et al. 1982).

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  1. F. G. M. Kroese
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  2. W. Timens
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  3. P. Nieuwenhuis
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  1. Gerhard-Domagk-Institut für Pathologie, der Universität Münster, Domagkstr. 17, 4400, Münster, Federal Republic of Germany

    E. Grundmann (Professor Dr.) & E. Vollmer (Dr. Dr.) (Professor Dr.) &  (Dr. Dr.)

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Kroese, F.G.M., Timens, W., Nieuwenhuis, P. (1990). Germinal Center Reaction and B Lymphocytes: Morphology and Function. In: Grundmann, E., Vollmer, E. (eds) Reaction Patterns of the Lymph Node. Current Topics in Pathology, vol 84/1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75519-4_5

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