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Biochemical Characterization of Cellular Hormone Receptors

  • Chapter
Cell Receptors

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 83))

Abstract

A large variety of cellular functions and physiological events are modulated or controlled by hormones and neurotransmitters. The cellular receptors for these molecules can be divided into two general categories: (a) cell surface receptors for peptides, growth factors, and neurotransmitters that are linked to secondary events (some of which are still unknown) (Kahn 1989), and (b) receptors for steroids, dihydrocholecalciferol, and thyroid hormones ultimately allowing interaction with specific DNA sequences and regulation of gene expression (Baulieu and Mester 1989). Modifications in hormone receptors and/or their secondary events have been implicated in a steadily growing number of pathophysiological disorders, thus making detailed knowledge of their primary structure and their functional properties increasingly important. Recent advances in receptor research have led to the isolation, cloning, and expression of multiple receptor proteins, and the subsequent dissection of functionally important domains through site-directed mutagenesis and site-specific monoclonal antibodies (Kris et al. 1985; Strader et al. 1988; Okamura et al. 1989; Cunningham et al. 1989).

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  1. H. Jüppner
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  2. R. D. Hesch
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  1. Institut für Pathologie, Universität Hamburg, Martinistraße 52, W-2000, Hamburg 20, Federal Republic of Germany

    G. Seifert Professor Dr.

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Jüppner, H., Hesch, R.D. (1991). Biochemical Characterization of Cellular Hormone Receptors. In: Seifert, G. (eds) Cell Receptors. Current Topics in Pathology, vol 83. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75515-6_3

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  • DOI: https://doi.org/10.1007/978-3-642-75515-6_3

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