Abstract
Cells of the mononuclear phagocyte system (MPS) are involved in the immune surveillance against microbial pathogens and malignant cells but are also important regulator cells in hematopoiesis [1, 2]. They are able to secrete a variety of factors that suppress or sitmulate the proliferation and differentiation of hematopoietic progenitor cells. Of these, macrophage colony-stimulating factor (M-CSF) and granulocyte-CSF have been shown to be released from monocytes [3], whereas the synthesis of GM-CSF is disputed [3, 4]. However, monocytes have to undergo maturation into macrophages to acquire the functional competence which is significant in vivo [5–7].
Supported by Deutsche Forschungsgemeinschaft and Bundesminister für Forschung und Technologie
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Chervenick PA. Lobuglio AF (1972) Human blood monocytes:stimulation of granulocyte and mononuclear colony formation in vitro. Science 178:164–166
Metcalf D (1984) The hemopoietic growth factors. Elsevier, Amsterdam
Oster W, Lindemann A, Mertelsmann R, Herrmann F (1989) Production of macrophage-, granulocyte-, granulocyte-macrophage- and multi-colony-stimulating factor by peripheral blood cells. Eur J Immunol 19:543–547
Sieff CA, Niemeyer CM, Mentzer SJ, Faller DV (1988) Interleukin-1, tumor necrosis factor, and the production of colony-stimulating factors by cultured mesenchymal cells. Blood 72:1316–1323
Andreesen R, Bross KJ, Osterholz J, Emmrich F (1986) Human macrophage maturation and heterogeneity:analysis with a newly generated set of monoclonal antibodies to differentiation antigens. Blood 67:1257–1264
Andreesen R, Gadd S, Costabel U, Leser HG, Speth V, Cesnik B, Atkins RC (1988) Human macrophage maturation and heterogeneity:restricted expression of late differentiation antigens in situ. Cell Tissue Res 253:271–279
Scheibenbogen C, Brugger W, Rordorf C, Andreesen R (1989) Developmental regulation and stimulus specifity of cytokine release by human macrophages, Exp Cell Biol 57:118
Andreesen R, Picht J, Lohr GW (1983) Primary cultures of human blood-borne macrophages grown on hydrophobic teflon membranes. J Immunol Methods 56:295–304
Hanamura T, Motoyoshi K, Yoshida K, Saito M, Miura Y, Kawashima T, Nishida M, Takaku F (1988) Quantitation and identification of human monocytic colony-stimulating factor in human serum by Enzyme-Linked Immunosorbent Assay. Blood 72:886–892
Haskill S, Johnson C, Eiermann D, Becker S, Warren K (1988) Adherence induces selective mRNA expression of monocyte mediators and proto-oncogenes. J Immunol 140:1690–1694
Shadduck RK, Waheed A, Wing E (1989) Demonstration of a blood-bone marrow barrier to M-CSF. Blood 73:68–73
Sampson-Johannes A, Ralph P (1987) Activation of human monocytes to tumoricidal state by recombinant CSF-1. RES Meeting Abstracts:345
Warren MK, Ralph P (1986) Macrophage growth factor CSF-1 stimulates human monoctye production of interferon, tumor necrosis factor, and colony stimulating activity. J Immunol 137:2281–2285
Brugger W, Andreesen R (1989) M-CSF is required for monocyte survival and acts as a cofactor for their terminal differentiation to macrophages in vitro, (submitted)
Hart PH, Whitty GA, Piccoli DS, Hamilton JA (1988) Synergistic activation of monocytes by GM-CSF and IFNg. J Immunol 141:1516–1521
Oster W, Lindemann A, Mertelsmann R, Herrmann F (1989) Granulocyte-macrophage colony-stimulating factor ( CSF) and multilineage CSF recruit human monocytes to express granulocyte CSF. Blood 73:64–67
Zsebo KM, Yuschenkoff VN, Schiffer S, Cgang D, McCall E, Dinarello C, Brown MA, Altrock B, Bagby GC (1988) Vascular endothelial cells and granulopoiesis:interleukin-1 stimulates the release of G-CSF and GM-CSF. Blood 71:99–103
Krishnan EC, Menon CD, Krishnan L, Jewell WR (1980) Deficiency in maturation process of macrophages in human cancer. JNCI 65:273–276
Andreesen R, Brugger W, Thomssen C, Rehm A, Speck B, Lohr GW (1989) Defective monocyte to macrophage maturation in patients with aplastic anemia. Blood 74:2150–2156
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag, Berlin Heidelberg
About this paper
Cite this paper
Scheibenbogen, C. et al. (1990). Secretion of Colony-Stimulating Factor for Macrophages (M-CSF) and Granulocyte/Macrophages (GM-CSF) is Developmentally Regulated in Human Macrophages. In: Freund, M., Link, H., Welte, K. (eds) Cytokines in Hemopoiesis, Oncology, and AIDS. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75510-1_6
Download citation
DOI: https://doi.org/10.1007/978-3-642-75510-1_6
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-52281-2
Online ISBN: 978-3-642-75510-1
eBook Packages: Springer Book Archive