Abstract
A major issue in assessing the efficacy of drugs for late-life cognitive disorders is that of clinical relevance or “ecologic validity.” It has been argued (Crook 1983, 1985a; Larrabee and Crook 1988; Leber 1986) that measures of treatment effects should bear a clear relationship to the behavioral problems for which treatment is undertaken. These behavioral problems may be assessed through rating scales completed by the clinician, the family of the patient, and sometimes the patient himself. Behavioral capacities may also be assessed directly through objective, psychometric performance tests. A major problem with most psychometric tests, however, is that they are abstract and bear little relationship to the behavioral problems for which drugs may be prescribed.
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Crook, T.H., Johnson, B.A., Larrabee, G.J. (1990). Evaluation of Drugs in Alzheimer’s Disease and Age-Associated Memory Impairment. In: Benkert, O., Maier, W., Rickels, K. (eds) Methodology of the Evaluation of Psychotropic Drugs. Psychopharmacology Series, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75370-1_3
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DOI: https://doi.org/10.1007/978-3-642-75370-1_3
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