Abstract
Selective photothermolysis (SPT) has recently been successfully applied to specifically destroy blood vessels in benign cutaneous vascular lesions such as portwine stains (PWS) (1–5). The principal of SPT is based upon the ability to target the laser light at specific chromophores or structures containing pigment in the laser exposed field. In the case of benign cutaneous vascular lesions, the endogenous chromophore chosen was the red pigment, oxyhemoglobin, found in abundance in red blood cells (RBC) within the abnormal blood vessels. Oxyhemoglobin (HbO2) has three absorption spectral peaks at 418, 542 and 577 nm (fig.1).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Morelli J. Tan OT, Garden. Tunable dye laser (577 nm) treatment of portwine stains. Lasers Surg Med 6:1:94–99/1986.
Tan OT, Gilchrest BA, Sherwood KA. Successful treatment of children with portwine stains using the flashlamp pulsed tunable dye laser. New Eng J Med 320: 416–21, 1989.
van Gemert MJC, Welch AJ, Amin AP. Is there an optimal treatment for portwine stains Lasers Surg Med 6: 76, 1986
Tan OT, Whitaker D, Garden J et al. Pulsed dye laser (577 nm) treatment of portwine stains: Ultrastructural evidence of of neovascularization and mast cell degranulation in healed tissue. J Invest Dermatol 90: 395–398, 1988.
Polla LL, Tan OT, Garden JM et al. Tunable dye laser for the treatment of benign cutaneous vascular ectasia. Dermatologica 174: 11–17, 1987.
Nakagawa H, Tan OT, Parrish JA. Ultrastructural changes in human skin after exposure to a pulsed laser. J. Invest Dermatol 84: 4: 396–400, 1985.
Garden J, Tan OT, Kerschmann R, Effect of pulse width on vessel specific changes induced by pulsed laser radiation. J. Invest Dermatol 87: 653–657, 1986.
Tan OT, Kerschmann R, Parrish JA. The effect of epidermal pigmentation on selective vascular effects of pulsed dye laser. Lasers Surg Med 4: 365–374, 1985.
Tong A, Tan OT, Parrish JA, Murphy G: Ultrastructure: Effects of melanin pigment on target specificity using a pulsed dye laser. J Invest Dermatol 88: 747–752, 1987.
Anderson RR, Parrish JA. Optical properties of human skin. In Regan JD and Parrish JA (eds) The science of photomedicine. Plenum Press, New York, 1982, p: 147–194.
Tan OT, Carney M, Margolis R, Seki Y, Boll J, Anderson RR, Parrish JA: Histologic responses of portwine stains treated by argon, carbon dioxide, and tunable dye lasers: a preliminary report. Arch Dermatol 122: 1016–1022, 1986.
Dixon JA, Huether S, Rotering RH: Hypertrophic scarring in argon laser treatment of portwine stains. Plast Reconstr Surg 73: 771–780, 1984.
Noe JM, Barsky SH, Geer DH et al. Portwine stains and the response to argon laser therapy: successful treatment of the predictive role of color, age and biopsy. Plast Reconstr Surg 65: 130–136, 1980.
Tan OT, Morrison P, Kurban AK. 585 nm for the treatment of portwine stains. Plast Reconstr Surg in press, 1990.
Tan OT Murray S, Kurban AK: Action spectrum of vascular specific injury using pulsed irradiation. J Invest Dermatol 92: 868–871, 1989.
Anderson RR, Parrish JA. Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation. Science 220: 524–527, 1983.
Apfelberg DB, Greene RA, Maser R et al. Results of argon laser exposure of capillary hemangioma in infancy: preliminary report. Plast Reconstr Surg 67: 188–193, 1981.
Scheibner A. Argon laser treatment of superficial blood vessel malformations on the trunk and extremities in adults and on the face in children. Lasers Surg Med 6: 224, 1986.
Morden SR, Rotteleur G, Buys B et al. Comparative study of the ‘point by point technique’ and the scanning technique for laser treatment of portwine stains. Lasers Surg Med 9: 398–404, 1989.
Ratz JL, Bailin PL, Levine HL. CO2 laser treatment of portwine stains: a preliminary report. J Dermatol Surg Oncol 8: 1039–1044, 1982.
Tan OT, Motemedi M, Welch AJ, Kurban AK: Spotsize effects in guinea pig skin caused by pulsed irradiation. J Invest Dermatol 90: 877–881, 1988.
Keijzer M, Jacques SL, Prahl SA, Welch AJ. Light distribution in artery tissue: Monte Carlo simulations for finite-diameter laser beams. Lasers Surg Med 9: 148–154, 1989.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Berlin, Heidelberg
About this paper
Cite this paper
Tan, O.T. (1991). Dye Laser for Benign Cutaneous Vascular Lesions: Clinical and Technical Development. In: Steiner, R., Kaufmann, R., Landthaler, M., Braun-Falco, O. (eds) Lasers in Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75201-8_5
Download citation
DOI: https://doi.org/10.1007/978-3-642-75201-8_5
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-75203-2
Online ISBN: 978-3-642-75201-8
eBook Packages: Springer Book Archive