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Indocyanine Green: Evaluation of Liver Function — Application in Intensive Care Medicine

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Practical Applications of Fiberoptics in Critical Care Monitoring

Abstract

With a sensitivity of 90%, conventional enzymatic liver function tests are sufficient for screening of liver disease, although specificity is low. The value of the quantitative function tests (Table 1) lies in their capacity to detect specific hepatocellular partial functions. Definition of severity and evaluation of functional restriction may give clues to the prognosis of a disease, to the indication for shunt operation, or to the necessity of therapy in chronic active hepatitis [3, 10, 13, 18, 20, 23, 26, 27].

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References

  1. Bax ND, Tucker GT, Woods HF (1978) Does indocyanine green predict lidocaine requirement? N Engl J Med 299: 662

    Google Scholar 

  2. Branch RA, James JA, Read AE (1976) The clearance of antipyrine and indocyanine green in normal subjects and in patients with chronic liver disease. Clin Pharmacol Ther 20: 81

    PubMed  CAS  Google Scholar 

  3. Caesar J, Sheldon S, Chiandussi L, Guevera L, Sherlock S (1961) The use of indocyanine green in the measurement of hepatic blood flow and as a test of hepatic function. Clin Sci 21: 43

    PubMed  CAS  Google Scholar 

  4. Cherrik GR, Stein SW, Leevy CM, Davidson CS (1960) Indocyanine green: Observation on its physical properties, plasma decay and hepatic extraction. J Clin Invest 39: 592

    Article  Google Scholar 

  5. Gottlieb ME, Stratton HH, Newell JC, Shah DM (1984) Indocyanine green. Its use as an early indicator of hepatic dysfunction following injury in man. Arch Surg 119: 264

    Article  PubMed  CAS  Google Scholar 

  6. Gugler R, Eichelbaum M (1981) Dosisanpassung von Medikamenten bei chronischen Lebererkrankungen. Leber Magen Darrn 11: 81

    CAS  Google Scholar 

  7. Hruby K, Kleinberger G (1982) Pharmakotherapie bei schwerer Leberinsuffizienz. Leber Magen Darm 12: 188

    PubMed  CAS  Google Scholar 

  8. Hunton DB, BollmannJL, Hoffmann HN (1960) Studies of hepatic function with indocyanine green. Gastroenterology 39: 713

    PubMed  CAS  Google Scholar 

  9. Iga T, Yokota M, Sugiyama Y, Awazu S, Hanano M (1980) Hepatic transport of indocyanine green in rats chronically intoxicated with carbon tetrachloride. Biochem. Pharmacol 29: 1291

    CAS  Google Scholar 

  10. Joly JG, Marleau D, Legare A, et al. (1971) Bleeding from esophageal varices in cirrhosis of the liver: Hemodynamic and radiologic criteria for selection of potential bleeders through hepatic and umbilicoportal catheterization studies. Can Med Ass J 104: 576

    PubMed  CAS  Google Scholar 

  11. Kardel T, Ramsoe K, Rasmussen N (1975) Preoperative liver function tests correlated with encephalopathy after porto-caval anastomosis. Scand J Gastroenterol 10: 29

    PubMed  CAS  Google Scholar 

  12. Kawasaki S, Sugiyama Y, Iga T, Hanano M (1985) Pharmacokinetic study on the hepatic uptake of indocyanine green in cirrhotic patients. Amer J Gastroentorol 80: 801

    CAS  Google Scholar 

  13. Kholoussy AM, Pollak D, Matsumoto T (1984) Prognostic significance of indocyanine green clearance in critically ill surgical patients. Crit Care Med 12: 115–116

    Article  PubMed  CAS  Google Scholar 

  14. Kuntz HD, May B (1983) Veränderungen der Leberfunktion bei Schockleber und akuter Stauungsleber. Z Intensivmed 20: 17

    Google Scholar 

  15. Kuntz HD, May B (1983) Quantitative Leberfunktionsdiagnostik. Münch Med Wschr 125: 678

    CAS  Google Scholar 

  16. Kuntz HD, Femfert U, Straub H, May B (1984) Fremdstoffmetabolismus bei Patienten mit chronischem Cor-pulmonale. Atemw Lungenerkr 12: 320

    Google Scholar 

  17. Leevy CM, Bender J (1963) Physiology of dye extraction by the liver: Comparative studies of sulfobromphthalein and indocyanine green. Ann N Y Acad Sci 111: 161

    Article  PubMed  CAS  Google Scholar 

  18. Leevy CM, Smith F, Longueville J, Paumgartner G, Howard MM (1967) indocyanine green clearance as a test for hepatic function. J Amer Med Ass 200: 236.

    Article  CAS  Google Scholar 

  19. Leevy CM, Leevy CB, Howard MM (1979) Indocyanine green and the liver. In: Problems in liver diseases. Davidson CS (ed) Thieme publishers, Stuttgart p 42

    Google Scholar 

  20. Moody FG, Rikkers LF, Aldrete JS (1974) Estimation of the functional reserve of human liver. Ann Surg 180: 592

    Article  PubMed  CAS  Google Scholar 

  21. Namihisa, Nambu N, Kobayashi N, Kuroda H (1981) Nine cases with marked retention of indocyanine green test and normal sulfobromphthaein test without abnormal liver histology: Constitutional indocyanine green excretory defect. Hepato-Gastroenterol 28: 6

    CAS  Google Scholar 

  22. Paumgartner G (1975) The handling of indocyanine green by the liver. Schw Med Wschr 105: Suppl 1

    Google Scholar 

  23. Pollak DS, Sufian S, Matsumoto T (1979) Indocyanine green clearance in critically ill patients. Surg Gynec Obstet 149: 852

    Google Scholar 

  24. Ranek L, Andreasen PB, Tygstrup N (1976) Galactose elimination capacity as a prognostic index in patients with fulminant liver failure. Gut 17: 959

    Article  PubMed  CAS  Google Scholar 

  25. Reid PR, Zito RA (1978) Does indocyanine green predict lidocaine requirement? N Engl J Med 299: 663

    Article  Google Scholar 

  26. Ritz R, Cavanilles J, Michaels S, Shubin H, Weil MH (1973) Disappearance of indocyanine green during circulatory shock. Surg Gynec Obstet 136: 57

    PubMed  CAS  Google Scholar 

  27. Zeppa R, Warren WD (1971) The distal splenorenal shunt. Am J Surg 122: 300

    Article  PubMed  CAS  Google Scholar 

  28. Bauer R (1906) Über die Assimilation von Galaktose und Milchzucker beim Gesunden und Kranken. Wien Med Wochenschr. 56: 20

    Google Scholar 

  29. Femert U, Kuntz HD, May B (1983) Rapid highperformance liquid chromatographic method for the measurement of hymecromon and its conjugates in blood plasma or serum at concentrations attained during therapy. J Chromatogr 278: 452–457

    Article  Google Scholar 

  30. Fox IJ, Brooker LGS, Heseltine DW, Essex HE, Wood EH (1957) A tricarbocyanin dye for continuous recording of dilution curves in whole blood independent of variations of blood oxygen saturation. Mayo Clin Proc 32: 478–484

    CAS  Google Scholar 

  31. Hepner GW, Vesell ES (1974) Assessments of hepatic function in man by breath analysis after oral administration of (14C) aminopyrine. N Engl J Med 291: 1384–1388

    Article  PubMed  CAS  Google Scholar 

  32. Rosenthal SM, White EC (1924) Studies in hepatic function. VI. A. The pharmacological behavior of certain phtalein dyes. B. The value of selected phtalein compounds in the estimation of hepatic function. J Pharmacol Exp Ther 24: 265

    CAS  Google Scholar 

  33. Tygstrup N (1964) The galactose elimination capacity in control subjects and patients with cirrhosis of the liver. Acta Scand 175: 281–289

    Article  CAS  Google Scholar 

  34. Vesell ES, Page JG (1968) Genetic control of drug levels in man: Antipyrine. Science 161: 72–73

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. H. D. Kuntz
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  2. W. Schregel
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Editor information

Editors and Affiliations

  1. Ward 3A, San Francisco General Hospital, 1001 Potrero Avenue, San Francisco, California, 94110, USA

    Frank R. Lewis Jr. M.D.

  2. Institut für Experimentelle Chirurgie Klinikum Rechts der Isar, Technische Universität München, Ismaningerstraße 22, München 80, D-8000, Germany

    Ulrich J. Pfeiffer

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© 1990 Springer-Verlag Berlin Heidelberg

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Kuntz, H.D., Schregel, W. (1990). Indocyanine Green: Evaluation of Liver Function — Application in Intensive Care Medicine. In: Lewis, F.R., Pfeiffer, U.J. (eds) Practical Applications of Fiberoptics in Critical Care Monitoring. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75086-1_7

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  • DOI: https://doi.org/10.1007/978-3-642-75086-1_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-51718-4

  • Online ISBN: 978-3-642-75086-1

  • eBook Packages: Springer Book Archive

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