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Early Predictors of Onset and Course of Schizophrenia and Schizophrenia Spectrum

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Search for the Causes of Schizophrenia

Abstract

The purpose of this article is to provide an overview of early predictors of the onset and course of schizophrenia, with special emphasis on the results from the temporally most advanced prospective study of children of schizophrenic mothers, launched in Copenhagen in 1962 by Mednick and Schulsinger (1965), the so-called Copenhagen High Risk Project. The focus will be on predictors of onset rather than those related to course.

Supported by National Institute of Mental Health grant MH 41 469 to Dr. Parnas

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References

  • Ainsworth MD (1962) The effects of maternal deprivation: a review of findings and controversy in the context of research strategy. In: Deprivation of maternal care: a reassessment of its effects. WHO, Geneva (Public Health papers no 14)

    Google Scholar 

  • Asarnow RF, Neuchterlein KH, Marder SR (1983) Span of apprehension performance, neuropsychological functioning, and indices of psychosis proneness. J Nerv Ment Dis 171:662–669

    Article  PubMed  CAS  Google Scholar 

  • Baron M, Gruen R, Rainer JD, Kain J, Asnis L, Lord S (1985) A family study of schizophrenic and normal control probands: implications for the spectrum concept of schizophrenia. Am J Psychiatry 142:447–455

    PubMed  CAS  Google Scholar 

  • Beliak L (1979) Schizophrenic syndrome related to minimal brain dysfunction: a possible neurologic subgroup. Schizophr Bull 5:480–489

    Google Scholar 

  • Bleuler E (1911/1950) Dementia praecox for the group of schizophrenias. International University Press, New York

    Google Scholar 

  • Bowlby J (1988) Developmental psychology comes from aging. Am J Psychiatry 145:1–10

    PubMed  CAS  Google Scholar 

  • Brown GW, Harris T (1978) Social origins of depression. Free Press, New York

    Google Scholar 

  • Burman B, Mednick SA, Machon RA, Parnas J, Schulsinger F (1987) Children at high risk for schizophrenia: parent and offspring perception of family relationships. J Abnorm Psychol 96:364–366

    Article  PubMed  CAS  Google Scholar 

  • Cannon TD, Mednick SA, Parnas J (1989a) Two pathways to schizophrenia in children at risk. In: Robins L, Rutter M (eds) Straight and devious pathways from childhood to adulthood. Cambridge University Press, Cambridge, pp 328–350

    Google Scholar 

  • Cannon TD, Mednick SA, Parnas J (1989b) Genetic and perinatal determinants of structural brain deficits in schizophrenia. Arch Gen Psychiatry 46:883–889

    PubMed  CAS  Google Scholar 

  • Chapman JL, Chapman JP (1985) Psychosis proneness. In: Alpert M (ed) Controversies in schizophrenia. Guilford, New York, pp 157–174

    Google Scholar 

  • Chapman JL, Chapmann JP (1987) The search for symptoms predictive of schizophrenia. Schizophr Bull 13:497–504

    PubMed  CAS  Google Scholar 

  • Ciompi L (1988) The psyche and schizophrenia: the bond between affect and logic. Harvard University Press, Cambridge

    Google Scholar 

  • Cohen P, Cohen J (1984) The clinician’s illusion. Arch Gen Psychiatry 41:1178–1182

    PubMed  CAS  Google Scholar 

  • Conrad AJ, Scheibel AB (1987) Schizophrenia and the hippocampus: the embryological hypothesis extended. Schizophr Bull 13:577–588

    PubMed  CAS  Google Scholar 

  • Conrad K (1968) Die beginnende Schizophrenie. Thieme, Stuttgart

    Google Scholar 

  • Dalén S (1975) Season of birth: a study of schizophrenia and other mental disorders. North Holland, Amsterdam

    Google Scholar 

  • De Clerambault G (1942) Oeuvre psychiatrique. Presses Universitaires de France, Paris

    Google Scholar 

  • Dohrenwend BP, Dohrenwend BS (1982) Perspectives on the past and future of psychiatric epidemiology. Am J Public Health 72:1271–1279

    Article  PubMed  CAS  Google Scholar 

  • Dohrenwend BP, Shrout P, Link BG, Martin JL, Skodel AE (1986) Overview and initial results from a risk factor study of depression and schizophrenia. In: Barrett JE (ed) Mental disorders in the community: progress and challenge. Guilford, New York, pp 184–215

    Google Scholar 

  • Endicott J, Spitzer R (1972) Current and past psychopathology scales (CAPPS). Arch Gen Psychiatry 27:678–687

    PubMed  CAS  Google Scholar 

  • Erlenmeyer-Kimling L, Marcuse Y, Comblatt B, Friedman D, Reiner JD, Rutchman J (1984) The New York High Risk Project. In: Watt NF, Anthony EJ, Wynne LC, Rolf JE (eds) Children at risk for schizophrenia: a longitudinal perspective. Cambridge University Press, New York, pp 169–189

    Google Scholar 

  • Erlenmeyer-Kimling L, Comblatt B (1987) The New York high risk project: a follow-up report. Schizophr Bull 13:451

    PubMed  CAS  Google Scholar 

  • Essen Moller E, Larsson H, Uddenberg CE, White G (1956) Individual traits and morbidity in a Swedish rural population. Acta Psychiatr Neurol Scand [Suppl] 100

    Google Scholar 

  • Fish B (1977) Neurobiologic antecedents of schizophrenia in children: evidence for an inherited, congenital, neurointegrative defect. Arch Gen Psychiatry 34:1297–1313

    PubMed  CAS  Google Scholar 

  • Fish B (1987) Infant predictors of the longitudinal course of schizophrenic development. Schizophr Bull 13:395–410

    PubMed  CAS  Google Scholar 

  • Freedman BJ, Chapman LJ (1973) Early subjective experience in schizophrenic episodes. J Abnorm Psychol 82:46–54

    Article  PubMed  CAS  Google Scholar 

  • Freedman BJ, Madison W (1974) The subjective experience of perceptual and cognitive disturbances in schizophrenia. Arch Gen Psychiatry 30:333–340

    PubMed  CAS  Google Scholar 

  • Goldstein MJ (1987) The UCLA high risk project. Schizophr Bull 13:505–514

    PubMed  CAS  Google Scholar 

  • Gottesman EE, Shields J (1982) The epigenetic puzzle. Cambridge University Press, Cambridge

    Google Scholar 

  • Gray JA (1987) The neuropsychology of anxiety. Oxford Science, Oxford

    Google Scholar 

  • Guze SB, Cloninger CR, Martin RL, Clayton PJ (1983) A follow-up and family study of schizophrenia. Arch Gen Psychiatry 40:1273–1276

    PubMed  CAS  Google Scholar 

  • Heinrichs DW, Buchannan RW (1988) Significance and meaning of neurological signs in schizophrenia. Am J Psychiatry 145:11–18

    PubMed  CAS  Google Scholar 

  • Huber G (1969) Klinische und neuroradiologische Untersuchungen an chronisch Schizophrenen. Nervenarzt 32:7–15

    Google Scholar 

  • Huber G (1983) Das Konzept substratnaher Basissymptome und seine Bedeutung für Theorie und Therapie schizophrener Erkrankungen. Nervenarzt 54:23–32

    PubMed  CAS  Google Scholar 

  • Jorgensen AA, Parnas J (1990) The Copenhagen High Risk Study: premorbid and clinical dimensions of maternal schizophrenia. J Nerv Ment Dis 178:370–376

    Article  PubMed  CAS  Google Scholar 

  • Jorgensen AA, Teasdale TW, Parnas J, Schulsinger F, Schulsinger H, Mednick SA (1987) The Copenhagen High Risk Project. The diagnosis of maternal schizophrenia and its relation to offspring diagnosis. Br J Psychiatry 151:753–757

    Article  PubMed  CAS  Google Scholar 

  • Kendler KS (1988) Familial aggregation of schizophrenia and schizophrenia spectrum disorders. Arch Gen Psychiatry 45:377–383

    PubMed  CAS  Google Scholar 

  • Kendler KS, Gruenberg AM, Strauss JS (1981) An independent analysis of the Copenhagen sample of the Danish adoption study. The relationship between schizotypal personality disorder and schizophrenia. Arch Gen Psychiatry 38:982–984

    PubMed  CAS  Google Scholar 

  • Kety SS (1988) Schizophrenic illness in the families of schizophrenic adoptees. Schizophr Bull 14:217–222

    PubMed  CAS  Google Scholar 

  • Klosterkötter J (1988) Basissymptome und Endphänomene der Schizophrenie. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Kraepelin E (1919/1971) Dementia praecox and paraphrenia. Krieger, New York

    Google Scholar 

  • Leff J, Kuipers L, Berkowitz R, Eberlein-Vries R, Sturgeon D (1982) A controlled trial of social intervention in the families of schizophrenic patients. Br J Psychiatry 141:121–134

    Article  PubMed  CAS  Google Scholar 

  • Machon RA, Mednick SA, Schulsinger F (1983) The interaction of seasonality, place of birth, genetic risk, and subsequent schizophrenia in a high risk sample. Br J Psychiatry 55:316–327

    Google Scholar 

  • Marcus J, Hans SL, Nagler S, Auerbach JG, Mirsky AF, Aubrey A (1987) Review of the NIMH Israeli Kibbutz-City study and the Jerusalem infant development study. Schizophr Bull 13:425–438

    PubMed  CAS  Google Scholar 

  • Matussek P (1952) Untersuchungen über die Wahnwahrnehmung. Arch Psychiatr Z Neurol 189:279–318

    Article  CAS  Google Scholar 

  • McGhie A, Chapman J (1961) Disorders of attention and perception in early schizophrenia. Br J Med Psychol 34:103–116

    Article  PubMed  CAS  Google Scholar 

  • McNeil TF, Kaij L (1978) Obstetric factors in the development of schizophrenia: complications in the birth of preschizophrenics and in the reproduction by schizophrenic parents. In: Wynne LC, Cromwell RL, Matthysse S (eds) The nature of schizophrenia. Wiley, New York, pp 401–429

    Google Scholar 

  • Mednick SA (1958) A learning theory approach to research in schizophrenia. Psychol Bull 55:316–327

    Article  PubMed  CAS  Google Scholar 

  • Mednick SA (1960) The early and advanced schizophrenic. In: Mednick SA, Higgins J (eds) Current research in schizophrenia. Edwards, Ann Arbor, pp 69–78

    Google Scholar 

  • Mednick SA, McNeil TF (1968) Current methodology in research on the etiology of schizophrenia: serious difficulties which suggest the use of the high-risk group method. Psychol Bull 21:681–693

    Article  Google Scholar 

  • Mednick SA, Schulsinger F (1965) A longitudinal study of children with a high-risk for schizophrenia: a preliminary report. In: Vandenberg S (ed) Methods and goals in human behavior genetics. Academic, New York, pp 255–296

    Google Scholar 

  • Mednick SA, Silverton L (1988) High risk studies of the etiology of schizophrenia. In: Tsuang MT, Simpson JC (eds) Handbook of schizophrenia, vol 3. Elsevier, Amsterdam, pp 543–562

    Google Scholar 

  • Mednick SA, Machon RA, Huttunen MO, Bonett D (1988) Adult schizophrenia following prenatal exposure to an influenza epidemic. Arch Gen Psychiatry 45:189–192

    PubMed  CAS  Google Scholar 

  • Meehl PE (1962) Schizotaxia, schizotypy, schizophrenia. Am Psychol 17:827–838

    Article  Google Scholar 

  • Meehl PE (1972) A critical afterword. In: Gottesman EE, Shields J (eds) Schizophrenia and genetics: a twin study vantage point. Academic, New York, pp 367–415

    Google Scholar 

  • Minkowski E (1927) La schizophrénie. Psychopathologie des schizoïdes et des schizophrènes. Payot, Paris

    Google Scholar 

  • Parnas J (1985) Mates of schizophrenic mothers: a study of assortative mating from the American/Danish High Risk Project. Br J Psychiatry 146:490–497

    Article  PubMed  CAS  Google Scholar 

  • Parnas J, Jorgensen AA (1989) Premorbid psychopathology in schizophrenia spectrum. Br J Psychiatry 155:623–627

    PubMed  CAS  Google Scholar 

  • Parnas J, Schulsinger H (1986) Continuity of formal thought disorder from childhood to adulthood in a high risk sample. Acta Psychiatr Scand 74:246–251

    Article  PubMed  CAS  Google Scholar 

  • Parnas J, Teasdale TW (1987) Treated versus untreated schizophrenia spectrum cases: a matched paired high risk population study. Acta Psychiatr Scand 75:44–50

    Article  PubMed  CAS  Google Scholar 

  • Parnas J, Schulsinger F, Schulsinger H, Teasdale TW, Mednick SA (1982a) Behavioral precursors of the schizophrenia spectrum. Arch Gen Psychiatry 39:658–664

    PubMed  CAS  Google Scholar 

  • Parnas J, Schulsinger F, Teasdale TW, Schulsinger H, Feldman PN, Mednick SA (1982b) Perinatal complications and clinical outcome within the schizophrenia spectrum. Br J Psychiatry 140:416–420

    Article  PubMed  CAS  Google Scholar 

  • Parnas J, Teasdale TW, Schulsinger H (1985) Institutional rearing and diagnostic outcome in children of schizophrenic mothers: a prospective high risk study. Arch Gen Psychiatry 42:762–769

    PubMed  CAS  Google Scholar 

  • Patterson T (1987) Studies toward the subcortical pathogenesis of schizophrenia. Schizophr Bull 13:555–576

    PubMed  CAS  Google Scholar 

  • Piaget J (1951) Principle factors determining intellectual evolution from childhood to adult life. In: Rappaport D (ed) Organization and pathology of thought. Columbia University Press, New York, pp 154–175

    Chapter  Google Scholar 

  • Popper K (1959) The logic of scientific discovery. Basic Books, New York

    Google Scholar 

  • Schulsinger H (1976) A ten-year follow up of children of schizophrenic mothers: a clinical assessment. Acta Psychiatr Scand 53:371–386

    Article  PubMed  CAS  Google Scholar 

  • Schulsinger F, Pamas J, Petersen ET, Schulsinger H, Teasdale TW, Mednick SA, Moller L, Silverton L (1984) Cerebral ventricular size in the offspring of schizophrenic mothers: a preliminary study. Arch Gen Psychiatry 41:602–606

    PubMed  CAS  Google Scholar 

  • Spitz RA (1965) The first year of life. International Universities Press, New York

    Google Scholar 

  • Spring B (1981) Stress and schizophrenia: some definitional issues. Schizophr Bull 7:24–33

    PubMed  CAS  Google Scholar 

  • Stransky E (1903) Zur Kenntnis gewisser erworbener Blödsinnsformen. Neurol Zentralbl 24:1–149

    Google Scholar 

  • Stransky E (1904) Zur Auffassung gewisser Symptome der Dementia Praecox. Neurol Zentralbl 24:1074–1085, 1137–1143

    Google Scholar 

  • Susser M (1973) Causal thinking in the health sciences. Oxford University Press, New York

    Google Scholar 

  • Tatossian A (1979) Phénomenologie des psychoses. Masson, Paris

    Google Scholar 

  • Tennant C (1984) Stress and schizophrenia. A review. Integrative Psychiatry 3:248–261

    Google Scholar 

  • Tienari P, Sorri A, Lakti I, Naarala M, Walhberg HE, Moring J, Pohjola J, Wynne LC (1987) Genetic and psychosocial factors in schizophrenia: the Finnish adoptive family study. Schizophr Bull 13:477–484

    PubMed  CAS  Google Scholar 

  • Tsuang MT, Winokur G, Crowe RR (1980) Morbidity risk of schizophrenia and affective disorders among first degree relatives of patients with schizophrenia, mania, depression, and surgical conditions. Br J Psychiatry 136:497–504

    Article  Google Scholar 

  • Varsamis J, Adamson JD (1971) Early schizophrenia. Can Psychiatr Assoc J 16:487–497

    PubMed  CAS  Google Scholar 

  • Weintraub S (1987) Risk factors in schizophrenia: the Stony Brook high risk project. Schizophr Bull 13:439–450

    PubMed  CAS  Google Scholar 

  • Wing JK, Brown DW (1970) Institutionalism and schizophrenia. Cambridge University Press, Cambridge

    Book  Google Scholar 

  • Wing JK, Cooper JE, Sartorius N (1974) The measurement and classification of psychiatric syndromes. Cambridge University Press, Cambridge

    Google Scholar 

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Author information

Authors and Affiliations

  1. Psychological Institute, Kommunehospitalet, 1399, Copenhagen, Denmark

    J. Parnas & S. A. Mednick

  2. Social Science Research Institute, University of Southern California, University Park, Los Angeles, CA, 90089, USA

    J. Parnas & S. A. Mednick

Authors
  1. J. Parnas
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  2. S. A. Mednick
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Editor information

Editors and Affiliations

  1. Central Institute of Mental Health, P.O. Box 122120, 6800, Mannheim 1, Germany

    Heinz Häfner  & Wagner Farid Gattaz  & 

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Parnas, J., Mednick, S.A. (1990). Early Predictors of Onset and Course of Schizophrenia and Schizophrenia Spectrum. In: Häfner, H., Gattaz, W.F. (eds) Search for the Causes of Schizophrenia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74881-3_4

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  • DOI: https://doi.org/10.1007/978-3-642-74881-3_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74883-7

  • Online ISBN: 978-3-642-74881-3

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