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Human Endogenous Retrovirus-like Sequences

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Modern Trends in Human Leukemia VIII

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 32))

Abstract

One of the most salient features of the replication strategy used by retroviruses is the transcription of the retroviral (RNA) genome into DNA followed by integration of this DNA product into the host cell genome. The integrated viral DNA copy, termed “provirus”, can then serve as a template for the synthesis of further infectious virus particles. Stably integrated proviruses have been found to also persist in the germ line of animal cells. In this case, they have become an endogenous constituent of their host cell’s genome and are passed on as stable Mendelian genes from one generation to the next.

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Author information

Authors and Affiliations

  1. GSF-Abt. für Molekulare Zellpathologie, D-8042, Neuherberg, Germany

    R. Brack-Werner & V. Erfle

  2. GSF-Institut für Säugetiergenetik, D-8042, Neuherberg, Germany

    T. Werner

  3. Medizinische Poliklinik der Universität München, D-8000, Munich, Germany

    C. Leib-Mösch

  4. III. Medizinische Klinik Mannheim der Universität Heidelberg, Wiesbadenerstr. 7-11, D-6800, Mannheim 31, Germany

    R. Hehlmann

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  1. R. Brack-Werner
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  2. C. Leib-Mösch
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  3. T. Werner
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  4. V. Erfle
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  5. R. Hehlmann
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Editors and Affiliations

  1. Medizinische Klinik, Abteilung für klinische Chemie, Universitäts-Krankenhaus Eppendorf, Martinistraße 52, 2000, Hamburg 20, Germany

    Rolf Neth

  2. Laboratory of Tumor Cell Biology, National Cancer Institute, 20892, Bethesda, MD, USA

    Robert C. Gallo

  3. Chester Beatty Laboratories, Leukemia Research Fund Centre, Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK

    Melvyn F. Greaves

  4. Abteilung Pädiatrie II, Universitätskinderklinik und Poliklinik Ulm, Prittwitzstr. 43, 7900, Ulm, Germany

    Gerhard Gaedicke

  5. Universität Ulm, Prittwitzstr. 43, 7900, Ulm, Germany

    Gerhard Gaedicke

  6. Labor für Hautimmunologie, Bioverträglichkeit-Immunologie, Paul-Gerson-Unna-Forschungszentrum, Beiersdorf-AG, Unnastr. 48, 2000, Hamburg 20, Germany

    Sven Gohla

  7. Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie, Martinistr. 52, 2000, Hamburg 20, Germany

    Klaus Mannweiler

  8. Abteilung Hämatologie und Onkologie, Kinderklinik und Poliklinik der Westfälischen Wilhelms-Universität, Albert-Schweitzer-Str. 33, 4400, Münster, Germany

    Jörg Ritter

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© 1989 Springer-Verlag Berlin Heidelberg

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Brack-Werner, R., Leib-Mösch, C., Werner, T., Erfle, V., Hehlmann, R. (1989). Human Endogenous Retrovirus-like Sequences. In: Neth, R., et al. Modern Trends in Human Leukemia VIII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 32. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74621-5_81

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  • DOI: https://doi.org/10.1007/978-3-642-74621-5_81

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50967-7

  • Online ISBN: 978-3-642-74621-5

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