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Immunohistochemical Investigation of Chordomas: Histogenetic and Differential Diagnostic Aspects

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Biological Characterization of Bone Tumors

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 80))

Abstract

Chordomas are tumors of very low incidence. Among 7400 cases collected in the Bone Tumor Registry of Westphalia, only 32 are chordomas, representing 0.4% of the total.

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References

  • Abenoza P, Sibley RK (1986) Chordoma: an immunohistochemical study. Hum Pathol 17: 744–747

    Article  PubMed  CAS  Google Scholar 

  • Abenoza P, Sibley KA, Rosai J (1985) Immunohistochemistry in differential diagnosis of chordoma and chondrosarcoma (abstract). Lab Invest 52: 1

    Google Scholar 

  • Ashley D (1978) In: Evan’s histological appearances of tumors, 3rd edn. Churchill Livingstone, Edinburgh

    Google Scholar 

  • Bannasch P, Zerban H, Mayer D (1982) The cytoskeleton in tumor cells. Pathol Res Pract 175: 196–211

    Article  PubMed  CAS  Google Scholar 

  • Botties K, Beckstead HJ (1984) Enzyme histochemical characterization of chordomas. Am J Surg Pathol B: 443–447

    Article  Google Scholar 

  • Bouropoulou V, Kontogeorgos G, Papamichales G, Bosse A, Roessner A, Vollmer E (1987) Differential diagnosis of chordoma. Immunohistochemical aspects. Arch Anat Cytol Pathol 35: 35–40

    PubMed  CAS  Google Scholar 

  • Bouropoulou V, Kontogeorgos G, Papamichales G, Milas P, Roessner A, Vollmer E, Grundmann E (1988) S-100 protein and neuron specific enolase expression by chordomas in relation to the composition of their stromal mucosubstances. Pathol Res Pract 183: 256–261

    Google Scholar 

  • Byers PD (1981) A study of histological features distinguishing chordoma from chondrosarcoma. Br J Cancer 43: 229–232

    Article  PubMed  CAS  Google Scholar 

  • Caselitz J, Osborn M, Seifert G, Weber K (1981) Intermediate-sized filament protein (prekeratin, vimentin, desmin) in normal parotid gland tumors. Immunofluorescence study. Virchows Arch 393: 273–286

    Google Scholar 

  • Caselitz J, Osborn M, Wustrow J, Seifert G, Weber K (1982) The expression of different intermediate-sized filaments in human salivary glands and their tumors. Pathol Res Pract 175: 266–278

    Article  PubMed  CAS  Google Scholar 

  • Chambers P, Schwinn C (1979) Chordoma. A clinico-pathologic study of metastases. Am J Clin Pathol 72: 765–776

    PubMed  CAS  Google Scholar 

  • Coindre JM, Rivell J, Trojani M et al. (1986) Immunohistological study of chordomas. J Pathol 150: 61–63

    Article  PubMed  CAS  Google Scholar 

  • Connel ND, Rheinwald JG (1983) Regulation of the cytoskeleton in mesothelial cells: reversible loss of keratin and increase in vimentin during rapid growth in culture. Cell 34: 245–253

    Article  Google Scholar 

  • Cook HC (1974) Manual of histological demonstration techniques. Butterworths, London

    Google Scholar 

  • Culling CFA (1974) Handbook of histopathological and histochemical techniques, 3rd edn. Butterworths, London

    Google Scholar 

  • Denk H, Krepier R, Artlieb V et al. (1983) Protein of intermediate filaments. An immunohistochemi-cal and biochemical approach to the Classification of soft tissue tumors. Am J Pathol 110: 193–208

    PubMed  CAS  Google Scholar 

  • Du Boulay CEH (1985) Immunohistochemistry of soft tissue tumors: a review. J Pathol 146: 77–94

    Article  PubMed  Google Scholar 

  • Erlandson RA, Cordon-Cardo C, Higgins P (1983) Coexpression of cytokeratin (CK), vimentin and actin in cells composing pleomorphic adenomas of salivary glands. An immunohistochemical and ultrastructural study. J Cell Biol 97: 219

    Google Scholar 

  • Filipe MI, Brian L (1983) Histochemistry in pathology. Churchill Livingstone, Edinburgh

    Google Scholar 

  • Fletcher CDM, Powell G, McKee PH (1986) Extraskeletal myxoid chondrosarcoma: a histochemical and immunohistochemical study. Histopathology 10: 489–499

    Article  PubMed  CAS  Google Scholar 

  • Gabbiani G, Kapanchi Y, Barazzone P, Franke WW (1981) Immunochemical identification of intermediate-sized filament in human neoplastic cells: a diagnostic aid for the surgical pathologist. Am J Pathol 104: 206–216

    PubMed  CAS  Google Scholar 

  • Hasegawa M, Nishiyima W, Watanabe I, Nasu M, Kamiyama R (1985) Primary chondroid chordoma arising from the base of the temporal bone. J Laryngol Otol 99: 485–489

    Article  PubMed  CAS  Google Scholar 

  • Heffelfinger MJ, Dahlin DC, MacCarthy CS, Beabout JW (1973) Chordomas and cartilaginous tumors at the skull base. Cancer 32: 410–420

    Article  PubMed  CAS  Google Scholar 

  • Holthöfer H, Miettienen A, Paasivuo R etal. (1983) Cellular origin and differentiation of renal carcinomas. A fluorescence microscopic study with kidney-specific antibodies, anti-intermediate filament antibodies and lectins. Lab Invest 49: 317–326

    PubMed  Google Scholar 

  • Huvos GA (1979) Bone tumors. Diagnosis, treatment and prognosis. Saunders, Philadelphia

    Google Scholar 

  • Iozzo VR (1984) Proteoglycans and neoplastic-mesenchymal cell interactions. Hum Pathol 15: 2–10

    Article  PubMed  CAS  Google Scholar 

  • Iraci G, Gerosa M, Pardatscher K (1973) Isolated Vernet’s Syndrome: an unusual manifestation of intracranial chordoma. Surg Neurol 1: 259–298

    Google Scholar 

  • Isaacson P, Judd AM (1988) Immunohistochemistry of carcinoembryonic antigen: characterization of cross-reactions with other glycoproteins. Gut 18: 779–785

    Article  Google Scholar 

  • Jaffe AG (1958) Tumors and tumorous conditions of bones and joints. Lea amp Febinger, Philadelphia

    Google Scholar 

  • Kempler R, Brulet P, Schnebelen MT, Gaillard J, Jacob (1981) Reactivity of monoclonal antibodies against intermediate filament proteins during embryonic development. J Embryol Exp Morphol 64: 45–60

    Google Scholar 

  • Lane EB, Hogan BLM, Kurkinen M, Garrels JI (1983) Coexpression of vimentin and cytokeratins in parietal endoderm cells of early mouse embryo. Nature 303: 701–704

    Article  PubMed  CAS  Google Scholar 

  • Lichtenstein L (1977) Bone tumors, 5th edn. CV Mosby, St. Louis

    Google Scholar 

  • Luschka H (1857) Ãœber gallertartige Auswüchse am Clivus Blumenbachii. Virchows Arch [Path Anat Physiol] 11: 8–12

    Article  Google Scholar 

  • Mehio AR, Ferenczy A (1978) Extraskeletal myxoid chondrosarcoma with chordoid features (chordoid sarcoma). Am J Clin Pathol 70: 700–705

    PubMed  CAS  Google Scholar 

  • Miettinen M (1984) Chordoma: antibodies to epithelial membrane antigen and carcinoembryonic antigen in differential diagnosis. Arch Pathol Lab Med 108: 891–892

    PubMed  CAS  Google Scholar 

  • Miettinen M, Lehto VP, Virtanen I (1983) Differential diagnosis of chordoma, chondroid, and ependymal tumors as aided by anti-intermediate filament antibody. Am J Pathol 112: 160–160

    PubMed  CAS  Google Scholar 

  • Mikuz G, Mydla F, Gutter K (1977) Ultrastrukturelle biochemische und cytomorphometrische Befunde beim Chordom. Beitr Pathol 161: 150–165

    PubMed  CAS  Google Scholar 

  • Müller H (1858) Ãœber das Vorkommen von Resten der Chorda dorsalis bei Menschen nach der Geburt und über ihr Verhältnis zu den Gallertgeschwülsten am Clivus. Z Rat Med 2: 202–229

    Google Scholar 

  • Nakamura Y, Becker L, Marks A (1983) S-100 protein in human chordomas and in human and rabbit notochord. Arch Pathol Lab Med 107: 118–120

    PubMed  CAS  Google Scholar 

  • Nakazato Y, Ishizeki J, Takahashi K et al. (1982) Localization of S-100 protein and glial fibrillary acidic protein-related antigen in pleomorphic adenoma of the salivary glands. Lab Invest 46: 621–626

    PubMed  CAS  Google Scholar 

  • Pardo-Mindan FJ, Guillen FJ, Villas C, Vasques JJ (1981) A comparative ultrastructural study of chondrosarcoma, chondroid sarcoma and chordoma. Cancer 47: 2611–2619

    Article  PubMed  CAS  Google Scholar 

  • Roessner A, Vollmer E, Zwadlo G et al. (1988) The cytogenesis of macrophages and osteoclast-like giant cells in bone tumors with special emphasis on the so-called fibrohistiocytic tumors

    Google Scholar 

  • Vialle G (1987) Co-expression of different intermediate filament proteins by human tumors (Abstr IX Europ Congr Path, Prague). Pathol Res Pract 182: 573

    Google Scholar 

  • Vollmer E, Bouropoulou V, Roessner A et al. (1985) Immunhistologische und elektronenmikroskopische Untersuchungen an Chordomen. Verh Dtsch Ges Pathol 69: 633

    Google Scholar 

  • Wellinger C (1975) Le chordome rachidien. Revue de la litterature depuis 1960. Rev Rhum Mal Osteoart 42: 287–295

    CAS  Google Scholar 

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Authors
  1. V. Bouropoulou
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  2. A. Bosse
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  3. A. Roessner
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  4. E. Vollmer
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  5. G. Edel
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  6. P. Wuisman
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  7. A. Härle
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Editor information

Editors and Affiliations

  1. Gerhard-Domagk-Institut für Pathologie der Universität, Domagkstraße 17, D-4400, Münster, Germany

    A. Roessner (Prof. Dr.) (Prof. Dr.)

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© 1989 Springer-Verlag Berlin Heidelberg

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Bouropoulou, V. et al. (1989). Immunohistochemical Investigation of Chordomas: Histogenetic and Differential Diagnostic Aspects. In: Roessner, A. (eds) Biological Characterization of Bone Tumors. Current Topics in Pathology, vol 80. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74462-4_8

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  • DOI: https://doi.org/10.1007/978-3-642-74462-4_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74464-8

  • Online ISBN: 978-3-642-74462-4

  • eBook Packages: Springer Book Archive

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