Summary
An allergological examination, including prick tests, scratch chamber tests, patch tests, and RAST tests, was performed in 83 consecutive patients exposed to isocyanates. Three cases of allergic contact dermatitis from isocyanates have been detected: the first patient was allergic to isophorone diisocyanate and trimethyl hexamethylene diisocyanate, the second to 4,4′-diphenylmethane diisocyanate (MDI) and toluene 2,4-diisocyanate (TDI), and the third to HDI and its prepolymer Desmodur-N. To our knowledge, this was the first patient reported to have allergic contact dermatitis from HDL The optimal patch test concentrations were 2%–5% in petrolatum for TDI and MDI, and 0.1%–0.2% in petrolatum for HDI, whereas 0.5% was irritant.
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References
Fregert S (1967) Allergic contact reaction to diphenyl-4,4′di-isocyanate. Contact Dermatitis Newsletter 2: 35.
Wodniansky P (1967) Hautschäden bei der Erzeugung von Polyurethan-Kunststoffen. Berufsdermatosen 15: 81–92.
Peschel H (1970) Hautveränderungen durch Isozyanate (Desmodur). Derm Monatsschr 156: 691–697.
Hjorth N (1975) Dermatitis from trimethyl hexamethylene di-isocyanate. Contact Dermatitis 1: 59.
Emmett E (1976) Allergic contact dermatitis in polyurethane plastic moulders. J Occup Med 18: 802–804.
Rothe A (1976) Zur Frage arbeitsbedingter Hautschädigungen durch Polyurethanchemikalien. Berufsdermatosen 24: 7–24.
Malten KE (1977) 4,4′-diisocyanato dicyclohexyl methane (Hylene W): a strong contact sensitizer. Contact Dermatitis 3: 344–346.
LaChapelle JM, LaChapelle-Ketelaer MJ (1979) Cross-sensitivity between isopropone diamine (IPD) and isopropone diisocyanate (IPDI). Contact Dermatitis 5: 55.
Lidén C (1980) Allergic contact dermatitis from 4,4′di-isocyanate-di-phenylmetane (MDI) in a molder. Contact Dermatitis 6: 301–302.
White IR, Stewart JR, Rycroft RJG (1983) Allergic contact dermatitis from an organic di-isocyanate. Contact Dermatitis 9: 300–303.
Fisher AA (1986) Contact dermatitis, 3rd edn. Lea and Febiger, Philadelphia, pp 562–565.
Alomar A (1986) Contact dermatitis from a fashion watch. Contact Dermatitis 15: 44–45.
Kanerva L, Estlander T, Jolanki R (1989) Allergic contact dermatitis from dental composite resins due to aromatic epoxy acrylates and aliphatic acrylates. Contact Dermatitis (in press).
Kanerva L, Tupasela O, Jolanki R, Vaheri E, Estlandet T, Keskinen H (1988) Occupational allergic rhinitis from guar gum. Clin Allergy 18: 245–252.
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© 1989 Springer-Verlag Berlin Heidelberg
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Kanerva, L., Lähteenmäki, MT., Estlander, T., Jolanki, R., Keskinen, H. (1989). Allergic Contact Dermatitis from Isocyanates. In: Frosch, P., Dooms-Goossens, A., Lachapelle, JM., Rycroft, R.J.G., Scheper, R.J. (eds) Current Topics in Contact Dermatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74299-6_76
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DOI: https://doi.org/10.1007/978-3-642-74299-6_76
Publisher Name: Springer, Berlin, Heidelberg
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