Abstract
Intraperitoneal injection of BALBc/An mice with a single 0.5 ml dose of the mineral oil pristane leads to the appearance of malignant Ig-secreting (usually IgA) plasma cells in 25% of mice after minimal latent periods of 120 days and mean latent periods between 210–220 days (Potter and Wax 1983). Over 95% of these plasmacytomas (PCTs) contain rcpt(12;15) or rcpt(6;15) chromosomal translocations in which the c-myc gene on chromosome 15 is juxtaposed with immunoglobulin heavy or light chain loci on chromosomes 12 and 6 respectively. These structural alterations disrupt the normal regulation of the c-myc gene which is thought to be causally related to the development of malignancy (reviewed in Potter 1984). Indeed infection of pristane primed mice with wild-type Moloney (Mo-MuLV) helper virus and the replication defective J-3 retrovirus, which contains a partially deleted raf oncogene and a hybrid MH2/MC29 avian v-myc oncogene induced shortened latency plasmacytomas which lacked c-myc translocations (Potter et. al. 1987). On the other hand experiments which used murine retroviruses harboring an LTR driven murine c-myc gene only induced myeloid malignancies in pristane primed mice (Wolff et. al. 1986).
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Clynes, R., Stanton, L.W., Wax, J., Smith-Gill, S., Potter, M., Marcu, K.B. (1988). Synergy of an IgH Promoter-Enhancer-Driven c-myc/v-Ha-ras Retrovirus and Pristane in the Induction of Murine Plasmacytomas. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1988. Current Topics in Microbiology and Immunology, vol 141. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74006-0_16
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DOI: https://doi.org/10.1007/978-3-642-74006-0_16
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