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Origin and Turnover of Monocytes and Macrophages

  • Chapter
Cell Kinetics of the Inflammatory Reaction

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 79))

Abstract

The first attempt to establish the bone marrow origin of macrophages was made in 1963 (Balner 1963). This study, done with mouse bone marrow chimeras and a cytotoxic antibody against the donor bone marrow cells, showed that in due course the peritoneal macrophages of the host were replaced by cells from the donor. This approach has since been followed by many researchers using various markers, and all of them came to the same conclusion, i.e., that macrophages derive from precursor cells in the bone marrow (Table 1). Some of these studies were done in man, i.e., in patients undergoing bone marrow or liver transplantation. Liver transplant patients do not represent true chimeras, but the replacement of the Kupffer cells in the donor liver by Kupffer cells from the host is based on the same principle as the replacement of host cells by donor cells after bone marrow transplantation. The use of chimeras has the drawback that they do not represent the true steady-state condition, because the treatment of the recipients with irradiation or cytotoxic drugs causes inflammation.

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  1. Institute of Pathology, University of Oslo, Rikshospitalet, N-0027, Oslo 1, Norway

    Olav Hilmar Iversen (Professor Dr.) (Professor Dr.)

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van Furth, R. (1989). Origin and Turnover of Monocytes and Macrophages. In: Iversen, O.H. (eds) Cell Kinetics of the Inflammatory Reaction. Current Topics in Pathology, vol 79. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73855-5_6

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  • DOI: https://doi.org/10.1007/978-3-642-73855-5_6

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