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The Neutrophilic Granulocyte

  • Chapter
Cell Kinetics of the Inflammatory Reaction

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 79))

Abstract

The red bone marrow — the source of all blood cells — is a large, but dispersed organ, about the size of the liver. In steady state, about 7 * 1010 mature neutrophilic granulocytes (hereafter called PMN-“polymorphonuclears” — or just granulocytes) – are mobilized daily from red bone marrow to blood. These ~ 20 ml of packed cells protect us against infections. Like the other blood cells, the PMN can be traced back to a pluripotent stem cell in the marrow. The stem cell population, by definition capable of extensive self-renewal, gives off cells for differentiation through several transit populations to the functional PMN end stage. During maturation rapid cell proliferation occurs down to and including the myelocyte stage (Fig. 1). Thereafter maturation without cell division takes place, assumedly in a first in-first out mode, through maturation and storage compartments (metamyelocytes, band neutrophils and PMN) (~ 1 week) (reviewed by Cartwright et al. 1964; Boggs 1967; Cronkite and Vincent 1969; Murphy 1976; Dancey et al. 1976).

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Authors
  1. H. B. Benestad
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  2. O. D. Laerum
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  1. Institute of Pathology, University of Oslo, Rikshospitalet, N-0027, Oslo 1, Norway

    Olav Hilmar Iversen (Professor Dr.) (Professor Dr.)

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Benestad, H.B., Laerum, O.D. (1989). The Neutrophilic Granulocyte. In: Iversen, O.H. (eds) Cell Kinetics of the Inflammatory Reaction. Current Topics in Pathology, vol 79. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73855-5_2

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  • DOI: https://doi.org/10.1007/978-3-642-73855-5_2

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