Abstract
The therapeutic options for acromegaly unsuitable for or unresponsive to surgery or dopaminergic agonists are limited. The short half-life (t1/2) of natural somatostatin has precluded its use, but a new, long-acting, octapeptide analog (SMS 201–995, Sandostatin®) has shown promise [2, 4, 5]. We have reported beneficial clinical and chemical responses in 6 patients with resistant acromegaly given Sandostatin for 5–12 months [1]. This study has since been extended to include 14 patients who have received Sandostatin up to a period of 30 months.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Barnard LB, Grantham WG, Lamberton MD, O’Dorisio TM, Jackson IMD (1986) Treatment of resistant acromegaly with a long-acting somatostatin analogue (SMS 201-995). Ann Intern Med 105: 856–861
Ch’ng JLC, Sandler LM, Kraenzlin ME, Burrin JM, Joplin GF, Bloom SR (1985) Chronic treatment of acromegaly with a long-acting somatostatin analogue. Br Med J 290: 284–285
Jackson IMD, Barnard LB, Lamberton P (1986) Role of a long-acting somatostatin analogue (SMS 201-995) in the treatment of acromegaly. Am J Med 81 [Suppl 6B]: 94–101
Lamberts SWJ, Oosterom R, Neufeld M, Del Pozo E (1985) The somatostatin analogue SMS 201-995 induces long-acting inhibition of growth hormone secretion without rebound hypersecretion in acromegalic patients. J Clin Endocrinol Metab 60: 1161–1165
Lamberts SWJ, Uitterlinden P, Verschoor L, van Dongen KJ, Del Pozo E (1985) Long-term treatment of acromegaly with the somatostatin analogue SMS 201–955. N Engl J Med 313: 1576–1580
Reubi JC, Landolt AM (1984) High density of somatostatin receptors in pituitary tumors from acromegalic patients. J Clin Endocrinol Metab 59: 1148–1151
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag, Berlin Heidelberg
About this paper
Cite this paper
Jackson, I.M.D., Barnard, L., Cobb, W., Hein, M., Perez, R. (1988). Long-Term Treatment of Resistant Acromegaly with a Somatostatin Analog (SMS 201–995, Sandostatin®). In: Lamberts, S.W.J. (eds) Sandostatin® in the Treatment of Acromegaly. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73694-0_20
Download citation
DOI: https://doi.org/10.1007/978-3-642-73694-0_20
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-73696-4
Online ISBN: 978-3-642-73694-0
eBook Packages: Springer Book Archive