Abstract
Isosorbide-5-mononitrate (IS-5-MN) has a predictable pharmacokinetic profile; it is nearly 100% bioavailable after oral dosing, does not undergo first pass metabolism, has a plasma half-life between 4 and 6 h, and has dose-linear kinetics between 10 and 80 mg [1–3]. A predictable pharmacokinetic profile is an advantage when studying dose response and designing dosage regimens to avoid nitrate tolerance.
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© 1987 Springer-Verlag Berlin Heidelberg
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Jones, J.P., Isosorbide-5-mononitrate Study Cooperative. (1987). Acute Dose Response of Isosorbide-5-Mononitrate in Patients with Effort Angina. In: Julian, D.G., Rittinghausen, R., Überbacher, H.J. (eds) Mononitrate II. International Boehringer Mannheim Symposia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72689-7_9
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DOI: https://doi.org/10.1007/978-3-642-72689-7_9
Publisher Name: Springer, Berlin, Heidelberg
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