Abstract
In the treatment of myocardial ischemia long acting nitrates, such as isosorbide dinitrate (ISDN), are mainly used to prevent episodes of vasospasm (in unstable angina) [1–3] and to increase the ischemic threshold in patients with significative atherosclerotic lesions (stable angina) [4]. In recent years pharmacokinetic studies have shown that ISDN undergoes rapid enzymatic degradation in the liver, where two main metabolites (2- and 5-mononitrate) are generated. Of the two active metabolites, 5-mononitrate (IS-5-MN) is detectable in human plasma 6–8 h after oral administration [5]. Such prolonged blood concentrations make this metabolite of clinical relevance in the treatment of angina pectoris which is mainly based on the effect of a given drug to prevent ischemic episodes. Aim of this study was to assess the effectiveness of oral IS-5-MN in preventing episodes of myocardial ischemia induced by isometric effort.
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© 1987 Springer-Verlag Berlin Heidelberg
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Lombardi, M., Distante, A., Moscarelli, E., Morales, M.A., L’Abbate, A. (1987). Preventative Effects of Isosorbide-5-Mononitrate on Myocardial Ischemia Induced by Hand-Grip Test: An Echocardiographic Study. In: Julian, D.G., Rittinghausen, R., Überbacher, H.J. (eds) Mononitrate II. International Boehringer Mannheim Symposia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72689-7_20
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DOI: https://doi.org/10.1007/978-3-642-72689-7_20
Publisher Name: Springer, Berlin, Heidelberg
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