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Endogenous Angiogenesis Inhibitors: Angiostatin, Endostatin, and Other Proteolytic Fragments

  • Chapter
Inhibitors of Cell Growth

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 20))

Abstract

In mammals, the vasculature develops by vasculogenesis and angiogenesis. Vasculogenesis is the de novo blood vessel formation from endothelial cells which are born from precursor cell types including hemangioblasts and angioblasts (Risau 1995). Vasculogenesis usually occurs during early embryonic development, including the formation of heart and aorta (Risau and Flamme 1995). Angiogenesis represents the process of growth of new capillaries from preexisting blood vessels (Folkman and Shing 1992). In adults, new blood vessels are generated virtually via angiogenesis. The vasculature remains quiescent in the adult mammal, except for transient processes of neovascularization in the female reproductive system. In response to an appropriate growth stimulus, endothelial cells can degrade the basement membrane locally. Simultaneously, the quiescent endothelial cells change their morphology, proliferate, migrate, invade into the surrounding stroma tissue, form microtubes, and sprout new capillaries. This complex process of angiogenesis implies the presence of multiple controls of the system, which can be switched on and off within a short period.

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Authors and Affiliations

  1. Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institute, 171-77, Stockholm, Sweden

    Yihai Cao

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  1. Yihai Cao
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Editors and Affiliations

  1. INSERM, 73 bis, Rue du Maréchal Foch, 78000, Versailles, France

    Alvaro Macieira-Coelho

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© 1998 Springer-Verlag Berlin Heidelberg

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Cao, Y. (1998). Endogenous Angiogenesis Inhibitors: Angiostatin, Endostatin, and Other Proteolytic Fragments. In: Macieira-Coelho, A. (eds) Inhibitors of Cell Growth. Progress in Molecular and Subcellular Biology, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72149-6_8

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  • DOI: https://doi.org/10.1007/978-3-642-72149-6_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-72151-9

  • Online ISBN: 978-3-642-72149-6

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