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Pathogenesis of Reovirus Infections of the Central Nervous System

  • Chapter
Reoviruses II

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 233/2))

Abstract

Reovirus infection in rodents, and predominantly mice, has been extensively utilized as an experimental model system for studying the pathogenesis of viral disease of the CNS (for review see Tyler and Fields 1988, 1996; Tyler 1991; Virgin et al. 1997). Rare cases of reovirus-induced neurological disease in humans, including encephalitis and meningitis (Van Tongeren 1957; Krainer and Aronson 1959; Joske et al. 1964; Johansson et al. 1996; Tyler, unpublished) have been reported. Isolated case reports purporting to show an association between reovirus infection and atypical forms of motor neuron disease and chronic mental illness are totally unconvincing (Averback 1982; Szirmai et al. 1983). Reovirus has also been associated with neurological illnesses in nonhuman animals, including hydrocephalus in monkeys (Sabin 1959), encephalitis in dogs (Masste and Shaw 1966), and ataxia in cats (Csiza 1974).

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Authors and Affiliations

  1. Departments of Neurology, Medicine, and Microbiology and Immunology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO, 80262, USA

    K. L. Tyler

  2. Neurology Service (127), Denver Veterans Affairs Medical Center, 1055 Clermont Street, Denver, CO, 80220, USA

    K. L. Tyler

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  1. Health Sciences Center, Department of Neurology, University of Colorado, 4200 East 9th Avenue, Campus Box B-182, Denver, CO, 80262, USA

    Kenneth L. Tyler M.D.

  2. Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA

    Michael B. A. Oldstone M.D.

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Tyler, K.L. (1998). Pathogenesis of Reovirus Infections of the Central Nervous System. In: Tyler, K.L., Oldstone, M.B.A. (eds) Reoviruses II. Current Topics in Microbiology and Immunology, vol 233/2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72095-6_6

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