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DNA Damage and Repair in Mouse Liver

  • Conference paper
Mouse Liver Tumors

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 10))

Abstract

The formation of DNA adducts in mouse liver has been demonstrated for numerous chemicals including members of most major classes of carcinogens. Considerably less is known about the persistence and repair of DNA adducts in mouse liver. Likewise, major gaps in present knowledge exist regarding the molecular dosimetry of DNA adducts and their potential for miscoding during continuous exposure to high versus low doses of carcinogens. A prime example of this is 2-acetylaminofluorene (2-AAF), the carcinogen used in the ED01 megamouse study. There are no molecular dosimetry studies on the DNA adducts of 2-AAF, even though such a unique data base exists for the dose-response relationship of mouse liver tumors. Reviewing the pertinent literature, identifying deficiencies, and conducting the required research will hopefully permit a better determination of the relevance of mouse liver tumors to man.

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Author information

Authors and Affiliations

  1. Department of Biochemical Toxicology and Pathobiology, Chemical Industry Institute of Toxicology, Research Triangle Park, NC, 27709, USA

    J. A. Swenberg & T. R. Fennell

Authors
  1. J. A. Swenberg
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  2. T. R. Fennell
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Editor information

Editors and Affiliations

  1. Department of Pharmacology and Therapeutics, Trinity College, University of Dublin, Dublin 2, Ireland

    Philip L. Chambers

  2. Institut für Toxikologie und Pharmakologie, der Universität Würzburg, Versbacher Landstraße 9, 8700, Würzburg, Germany

    Dietrich Henschler

  3. Institut für Toxikologie, der Universität Mainz, Obere Zahlbacher Straße 67, 6500, Mainz, Germany

    Franz Oesch

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© 1987 Springer-Verlag

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Swenberg, J.A., Fennell, T.R. (1987). DNA Damage and Repair in Mouse Liver. In: Chambers, P.L., Henschler, D., Oesch, F. (eds) Mouse Liver Tumors. Archives of Toxicology, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71617-1_15

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  • DOI: https://doi.org/10.1007/978-3-642-71617-1_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17124-9

  • Online ISBN: 978-3-642-71617-1

  • eBook Packages: Springer Book Archive

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