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Neurogenesis in the Vertebrate Main Olfactory Epithelium

  • Chapter
Ontogeny of Olfaction

Abstract

It is generally accepted that the olfactory system is unique among the senses since the olfactory receptor cells, which are primary neurons, are thought to have a limited life span. Implicit in the current literature is the notion that these receptor cells are born, live and die by some “inherent clock” which, in mammals, lead to neuronal death after about 30 days (Moulton 1974; Graziadei and Monti Graziadei 1979). The turnover of receptor cells and their “programmed” replacement from a basally located progenitor cell compartment is thought to continue throughout the life of an animal and at a constant rate. This concept has gradually developed since Nagahara (1940) first reported the appearance of mitotic activity in the olfactory epithelium proprium of adult mice. Mitosis of basally located progenitor cells and repair of experimentally destroyed sensory cells was subsequently confirmed in a variety of other species (Lams 1940; Schultz 1941, 1960; Smith 1951; Bimes and Planel 1952; Westerman and von Baumgarten 1964; Andres 1965; Thornhill 1970; Craziadei and Metcalf 1971; Craziadei and Dehan 1973; Moulton 1974; Graziadei 1973; Breipohl and Ohyama 1981; Simmons et al. 1981; Matulionis 1982). Recent investigations on cell proliferation, cell death and repair by Hinds et al. (1984), Balboni and Vannelli (1982), Matulionis (1982) and our own group (Breipohl 1982b; Breipohl et al. 1985 a,b; 1986) lead to some doubt about a constant turnover of olfactory receptor cells throughout life.

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Author information

Authors and Affiliations

  1. Department of Anatomy, University of Queensland, St.Lucia, 4067, Australia

    W. Breipohl

  2. Department of Physiology, University of Adelaide, Australia

    A. Mackay-Sim

  3. Institut für Anatomie, Universitätsklinikum Essen, 4300, Essen, Germany

    D. Grandt, B. Rehn & C. Darrelmann

Authors
  1. W. Breipohl
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  2. A. Mackay-Sim
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  3. D. Grandt
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  4. B. Rehn
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  5. C. Darrelmann
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Editor information

Editors and Affiliations

  1. Department of Anatomy, University of Queensland, St. Lucia/Brisbane, Australia, 4067

    Winrich Breipohl

  2. Institut für Biologie III, Universität Tübingen, 7400, Tübingen, Germany

    Raimund Apfelbach

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© 1986 Springer-Verlag Berlin Heidelberg

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Breipohl, W., Mackay-Sim, A., Grandt, D., Rehn, B., Darrelmann, C. (1986). Neurogenesis in the Vertebrate Main Olfactory Epithelium. In: Breipohl, W., Apfelbach, R. (eds) Ontogeny of Olfaction. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71576-1_2

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  • DOI: https://doi.org/10.1007/978-3-642-71576-1_2

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