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Chemistry of Stable Prostacyclin Analogues: Synthesis of Iloprost

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Prostacyclin and Its Stable Analogue Iloprost

Abstract

The discovery of prostacyclin (PGI2) and its potent inhibitory action on platelet aggregation in 1976 by S. Moncada, R. Gryglewski, S. Bunting and J.R. Vane [1], has not only revolutionized concepts in cardiovascular research but has also made this important molecule a target for intensive biological and chemical research.

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References

  1. Moncada S, Gryglewski R, Bunting S, Vane JR (1976) An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 263: 663

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Author information

Authors and Affiliations

  1. Department of Chemistry, Research Laboratories of Schering AG, Berlin, Germany

    W. Skuballa, B. Radüchel & H. Vorbrüggen

Authors
  1. W. Skuballa
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  2. B. Radüchel
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  3. H. Vorbrüggen
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Copernicus Academy of Medicine, 16 Grzegórzecka, 31531, Cracow, Poland

    R. J. Gryglewski

  2. Cardiovascular Pharmacology, Schering AG, Müllerstraße 170–178, 1000, Berlin 65, Germany

    G. Stock

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© 1987 Springer-Verlag, Berlin Heidelberg

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Skuballa, W., Radüchel, B., Vorbrüggen, H. (1987). Chemistry of Stable Prostacyclin Analogues: Synthesis of Iloprost. In: Gryglewski, R.J., Stock, G. (eds) Prostacyclin and Its Stable Analogue Iloprost. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71499-3_2

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  • DOI: https://doi.org/10.1007/978-3-642-71499-3_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71501-3

  • Online ISBN: 978-3-642-71499-3

  • eBook Packages: Springer Book Archive

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