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Electrical and Mechanical Effects of Prostacyclin in the Canine Carotid Artery

  • Conference paper
Prostacyclin and Its Stable Analogue Iloprost

Abstract

Prostacyclin (PGI2), the main but unstable metabolite of arachidonic acid in vascular tissue, has potent cardiocirculatory properties [4, 8, 16]. Besides being the most effective platelet anti-aggregating substance, PGI2 has been reported to relax a variety of vascular preparations [4, 5, 10,15, 17], to reduce myogenic activity [10], and to inhibit transmission at the neuromuscular junction [15]. These vasodilatory actions were found both in isolated blood vessels [4] and in the intact organism [1, 7].

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Author information

Authors and Affiliations

  1. Institute of Physiology, Biophysical Research Group, The Free University of Berlin, Germany

    G. Siegel, F. Schnalke & B. Litza

  2. Cardiovascular Pharmacology, Research Laboratories of Schering AG, Berlin, Germany

    G. Stock

Authors
  1. G. Siegel
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  2. G. Stock
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  3. F. Schnalke
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  4. B. Litza
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Copernicus Academy of Medicine, 16 Grzegórzecka, 31531, Cracow, Poland

    R. J. Gryglewski

  2. Cardiovascular Pharmacology, Schering AG, Müllerstraße 170–178, 1000, Berlin 65, Germany

    G. Stock

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© 1987 Springer-Verlag, Berlin Heidelberg

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Siegel, G., Stock, G., Schnalke, F., Litza, B. (1987). Electrical and Mechanical Effects of Prostacyclin in the Canine Carotid Artery. In: Gryglewski, R.J., Stock, G. (eds) Prostacyclin and Its Stable Analogue Iloprost. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71499-3_17

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  • DOI: https://doi.org/10.1007/978-3-642-71499-3_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71501-3

  • Online ISBN: 978-3-642-71499-3

  • eBook Packages: Springer Book Archive

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