Skip to main content

Epithelial Tumor Markers: Special Markers of Glandular Differentiation

  • Chapter
Morphological Tumor Markers

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 77))

Abstract

There are principally two types of epithelial tumor markers: (1) Normal cell products with known functional properties which may appear in increased or reduced amounts during malignant development; and (2) So-called oncodevelopmental antigens. The latter markers are mainly expressed in fetal life but may appear in increased amounts in neoplastic lesions. Examples of such antigens are alpha fetoprotein (AFP) and carcinoembryonic antigen (CEA). In the present chapter, however, only the former category of tumor markers will be included and the discussion will be limited to salivary glands, breast and large bowel mucosa.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Arends JW, Wiggers T, Thijs CT, Verstijnen C, Swaen GJV, Bosman FT (1984) The value of secretory component ( SC) immunoreactivity in diagnosis and prognosis of colorectal carcinomas. Am J Clin Pathol 82: 267–274

    Google Scholar 

  • Arnold RR, Cole MF, McGee JR (1977) A bactericidal effect for human lactoferrin. Science 197: 263–265

    PubMed  CAS  Google Scholar 

  • Benacerraf B (1981) Role of MHC gene products in immune regulation. Science 212: 1229–1238

    PubMed  CAS  Google Scholar 

  • Bhan AK, DesMarais CL (1983) Immunhistologic characterization of major histocompatibility antigens and inflammatory cellular infiltrate in human breast cancer. JNCI 71: 507–516

    PubMed  CAS  Google Scholar 

  • Boland CR, Montgomery CK, Kim YS (1982) A cancer-associated mucin alteration in benign colonic polyps. Gastroenterology 82: 664–672

    PubMed  CAS  Google Scholar 

  • Brandtzaeg P (1974a) Mucosal and glandular distribution of immunoglobulin components. Immuno-histochemistry with a cold ethanol-fixation technique. Immunology 26: 1101–1114

    PubMed  CAS  Google Scholar 

  • Brandtzaeg P (1974b) Human secretory component. II Physicochemical characterization of free secretory component purified from colostrum. Scand J Immunol 3: 707–716

    PubMed  CAS  Google Scholar 

  • Brandtzaeg P (1974c) Mucosal and glandular distribution of immunoglobulin components. Differential localization of free and bound SC in secretory epithelial cells. J Immunol 112: 1553–1559

    PubMed  CAS  Google Scholar 

  • Brandtzaeg P (1977) Immunohistochemical studies on various aspects of glandular immunoglobulin transport in man. Histochemical J 9: 553–572

    CAS  Google Scholar 

  • Brandtzaeg P (1981) Prolonged incubation time in immunohistochemistry: effects on fluorescence staining of immunoglobulins and epithelial components in ethanol- and formalin-fixed paraffin- embedded tissues. J Histochem Cytochem 29: 1302–1315

    PubMed  CAS  Google Scholar 

  • Brandtzaeg P (1983) The secretory immune system of lactating human mammary glands compared with other exocrine organs. Ann NY Acad Sci 409: 353–383

    PubMed  CAS  Google Scholar 

  • Brandtzaeg P (1985) Role of J Chain and secretory component in receptor-mediated glandular and hepatic transport of immunoglobulins in man. Scand J Immunol 22: 111–146

    CAS  Google Scholar 

  • Brandtzaeg P, Baklien K (1977) Intestinal secretion of IgA and IgM: A hypothetical model. In: Immunology of the gut. Ciba Found Symp 46: 106–113

    Google Scholar 

  • Brandtzaeg P, Rognum TO (1983) Evaluation of tissue preparation methods and paired immunofluorescence staining for immunocytochemistry of lymphomas. Histochem J 15: 655–689

    PubMed  CAS  Google Scholar 

  • Brandtzaeg P, Rognum TO ( 1984 a) Evaluation of nine different fixatives. 1. Preservation of immunoglobulin isotypes, J chain, and secretory component in human tissues. Pathol Res Pract 179: 250–266

    Google Scholar 

  • Brandtzaeg P, Rognum TO (1984b) Evaluation of nine different fixatives. 2. Preservation of IgG, IgA and secretory component in artificial immunohistochemical test substrate. Histochemistry 81: 313–319

    Google Scholar 

  • Bullen JJ, Rogers HJ, Leigh L (1972) Iron-binding proteins in milk and resistance to Escherichia coli infection in infants. Br Med J 1: 69–75

    PubMed  CAS  Google Scholar 

  • Caselitz J, Jaup T, Seifert G (1981) Lactoferrin and lysozyme in carcinomas of the parotid gland. A comparative immunocytochemical study with the occurence in normal and inflamed tissue. Virchows Arch (Pathol Anat) 394: 61–73

    Google Scholar 

  • Caselitz J, Seifert G, Jaup T (1982) Tumour antigens in neoplasms of the human parotid gland. J Oral Pathol 11: 374–386

    PubMed  CAS  Google Scholar 

  • Caselitz J, Seifert G, Grenner G, Schmidtberger R (1983) Amylase as an additional marker of salivary gland neoplasms. Pathol Res Pract 176: 276–283

    PubMed  CAS  Google Scholar 

  • Caselitz J, Salfelder A, Seifert G (1984) Adenolymphoma: a immunohistochemical study with monoclonal antibodies against lymphocyte antigens. J Oral Pathol 13: 438–447

    PubMed  CAS  Google Scholar 

  • Caselitz J, Lunau U, Hamper K, Schmiegelow P (1985) The pleomorphic adenoma of salivary glands transplanted on athymic mice. A lightmicroscopical and immunohistochemical investigation. Virchows Arch (Pathol Anat) 408: 191–209

    Google Scholar 

  • Caselitz J, Schulze I, Seifert G (1986) Adenoid cystic carcinoma of the salivary glands: an immunohistochemical study. J Oral Pathol 15: 308–318

    PubMed  CAS  Google Scholar 

  • Csiba A, Whitwell HL, Moore M (1984) Distribution of histocompatibility and leucocyte differentiation antigens in normal human colon and in benign and malignant colonic neoplasms. Br J Cancer 50: 699–709

    PubMed  CAS  Google Scholar 

  • Daar AS, Fabre JW (1983) The membrane antigens of human colorectal cancer cells: Demonstration with monoclonal antibodies of heterogeneity within and between tumors and of anomalous expression of HLA-DR. Eur J Cancer Clin Oncol 19: 209–222

    Google Scholar 

  • Daar AS, Fuggle SV, Ting A, Fabre JW (1982) Anomalous expression of HLA-DR antigens on human colorectal cancer cells. J Immunol 129: 447–449

    PubMed  CAS  Google Scholar 

  • Dawson PA, Filipe MI (1976) An ultrastructural and histochemical study of the mucous membrane adjacent to and remote from carcinoma of the colon. Cancer 37: 2388–2398

    PubMed  CAS  Google Scholar 

  • Dukes CE, Bussey HJR (1958) The spread of rectal cancer and its effect on prognosis. Br J Cancer 12: 309–320

    PubMed  CAS  Google Scholar 

  • Erlandson RA, Cardon-Cardo C, Higgins PJ (1984) Histogenesis of benign pleomorphic adenoma (mixed tumor) of the major salivary glands. An ultrastructural and immunohistochemical study. Am J Surg Pathol 8: 803–820

    Google Scholar 

  • Fantasia JE, Lally ET (1984) Localization of free secretory component in pleomorphic adenomas of minor salivary gland origin. Cancer 53: 1786–1789

    PubMed  CAS  Google Scholar 

  • Filipe MI, Branfoot AC (1974) Abnormal patterns of mucus secretion in apparently normal mucosa of large intestine with carcinoma. Cancer 34: 282–290

    PubMed  CAS  Google Scholar 

  • Filipe MI, Branfoot AC (1976) Mucin histochemistry of the colon. Curr Top Pathol 63: 143–178

    PubMed  CAS  Google Scholar 

  • Flemming A (1922) On a remarkable bacteriolytic element found in tissues and secretions. Proc RSoc B93: 306–317

    Google Scholar 

  • Fleming KA, McMichael A, Morton JA, Woods J, McGee JOD (1981) Distribution of HLA class I antigens in normal human tissue and in mammary cancer. J Clin Pathol 34: 779–784

    PubMed  CAS  Google Scholar 

  • Franzen L, Carlssø B, Ã…ngstrøm T (1979) Cytology and cytochemistry of acinic cell carcinoma. Acta Otolaryngol Suppl 360: 174–177

    PubMed  CAS  Google Scholar 

  • Ghosh AK, Moore M, Street AJ, Howat JMT, Schofield PF (1986) Expression of HLA-D sub-region products on human colorectal carcinoma. Int J Cancer 38: 459–464

    PubMed  CAS  Google Scholar 

  • Gion M, Mione R, Dittadi R, Fasan S, Pallini A, Bruscagnin G (1986) Carcinoembryonic antigen, ferritin, and tissue polypeptide antigen in serum and tissue. Relationship with the receptor content in breast carcinoma. Cancer 57: 917–922

    Google Scholar 

  • Goh HS, Jass JR (1986) DNA content and the adenoma-carcinoma sequence in the colorectum. J Clin Pathol 39: 387–392

    PubMed  CAS  Google Scholar 

  • Harris JP, South MA (1981) Secretory component. A glandular epithelial cell marker. Am J Pathol 105: 47–53

    Google Scholar 

  • Harris JP, Caleb MH, South MA (1975) Secretory component in human mammary carcinoma. Cancer Res 35: 1861–1864

    PubMed  CAS  Google Scholar 

  • Hayashi Y, Yanagawa T, Yoshida H, Yura Y, Nitta T, Sato M (1985) Induction of other differentiation stages in neoplastic epithelial duct and myoepithelial cells from the human salivary gland grown in athymic nude mice. Cancer 55: 2575–2583

    PubMed  CAS  Google Scholar 

  • Hodes JE, Hull MT, Karn RC, Merritt AD, Hodes ME (1981) Immunohistochemical demonstration of the loss of immunoreactive amylase from neoplastic human salivary gland. Experientia 37: 184–187

    PubMed  CAS  Google Scholar 

  • Hsu SM, Hsu PL, Nayak RN (1981) Warthin’s tumour: an immunohistochemical study of its lymphoid stroma. Hum Pathol 12: 251–257

    PubMed  CAS  Google Scholar 

  • Iacono VJ, MacKay BJ, DiRienzo S, Pollock JJ (1980) Selective antibacterial properties of Lysozyme for oral microorganisms. Infect Imm 29: 623–632

    CAS  Google Scholar 

  • Isaacson P (1976) Tissue demonstration of carcinoembryonic antigen (CEA) in ulcerative colitis. Gut 17: 561–567

    PubMed  CAS  Google Scholar 

  • Isaacson P (1982) Immunoperoxidase study of the secretory immunoglobulin system in colonic neo-plasia. J Clin Pathol 35: 14–25

    PubMed  CAS  Google Scholar 

  • Jacobsen N, Lyche Melvaer K, Hensten-Pettersen A (1976) Some properties of salivary amylase: A survey of the literature and some observations. J Dent Res 51: 381–388

    Google Scholar 

  • Jass JR (1986) Lymphocyte infiltration and survival in rectal cancer. J Clin Pathol 39: 585–589

    PubMed  CAS  Google Scholar 

  • Jass JR, Fauldy J (1985) Immunohistochemical demonstration of IgA and secretory component in relation to epithelial cell differentiation in normal colorectal mucosa and metaplastic polyp: A semiquantitative study. Histochem J 17: 373–380

    Google Scholar 

  • Jass JR, Filipe MI, Abbas S, Falcon CAJ, Wilson Y, Lovell D (1984) A morphological and histochemical study of metaplastic polyps of the colorectum. Cancer 53: 510–515

    PubMed  CAS  Google Scholar 

  • Kaye GI, Fenoglio CM, Pascal RR, Lane N (1973) Comparative electron microscopic features of normal, hyperplastic, and adenomatous human colonic epithelium. Gastroenterology 64: 926–945

    PubMed  CAS  Google Scholar 

  • Korsrud FR, Brandtzaeg P (1982) Characterization of epithelial elements in human major salivary glands by functional markers: Localization of amylase, lactoferrin, lysozyme, secretory component and secretory immunoglobulins by paired immunofluorescence staining. J Histochem Cytochem 30: 657–666

    Google Scholar 

  • Korsrud FR, Brandtzaeg P (1984a) Immunofluorescence study of secretory epithelial markers in pleomorphic adenomas. Virchows Arch (Pathol Anat) 403: 291–300

    CAS  Google Scholar 

  • Korsrud FR, Brandtzaeg P (1984b) Immunohistochemical characterization of cellular immunoglobulins and epithelial marker antigens in Warthin’s tumour. Hum Pathol 15: 361–367

    PubMed  CAS  Google Scholar 

  • Kraus FW, Mestecky J (1971) Immunohistochemical localization of amylase, lysozyme and immunoglobulins in the human parotid gland. Arch Oral Biol 16: 781–789

    PubMed  CAS  Google Scholar 

  • Kvale D, Rognum TO, Thorud E, FossÃ¥ SD, Roe JS (1987a) Circulating secretory component (SC) in breast neoplasms. Secretory IgA and secretory IgM in serum related to CEA and to histological grade, DNA ploidy, and expression of SC, IgA, and CEA. Am J Clin Pathol (to be published )

    Google Scholar 

  • Kvale D, Rognum TO, Brandtzaeg P (1987b) Elevated levels of secretory immunoglobulins A and M in serum of patients with large bowel carcinoma indicate liver metastasis. Cancer 59: 203–207

    PubMed  CAS  Google Scholar 

  • Lai A, Fat RFM, McClelland DBL, van Furth R (1976) In vitro synthesis of immunoglobulins, secretory component, complement and lysozyme by human gastrointestinal tissues. I Normal tissues. Clin Exp Immunol 23: 9–19

    Google Scholar 

  • Lee PP, Buehring GC (1981) Local immunoglobulin A in normal and neoplastic breast tissues. J Natl Cancer Inst 67: 1231–1239

    PubMed  CAS  Google Scholar 

  • Lennard-Jones JE, Morson BC, Ritchie JK, Williams CB (1983) Cancer surveillance in ulcerative colitis. Lancet 11: 149–152

    Google Scholar 

  • Lwin KY, Zuccarini O, Sloane JP, Beverly PCL (1985) An immunohistological study of leukocyte localization in benign and malignant breast tissue. Int J Cancer 36: 433–438

    PubMed  CAS  Google Scholar 

  • Masson PL, Heremans JF, Dive C (1966) An iron-binding protein common to many external secretions. Clin Chim Acta 14: 735–739

    CAS  Google Scholar 

  • McClelland DBL, van Furth R (1975) In vitro synthesis of lysozyme by human and mouse tissues and leucocyts. Immunology 28: 1099–1114

    PubMed  CAS  Google Scholar 

  • McGuire WL, Pearson OH, Segaloff A (1975) Predicting hormone responsiveness in human breast cancer. In: WL McGuire, PP Carbone, EP Vollmer (eds) Estrogen receptors in human breast cancer. Raven Press, New York, pp 17–30

    Google Scholar 

  • Momburg F, Degener T, Bacchus E, Moldenhauer G, Hämmerling GJ, Möller P (1986) Loss of HLA-A, B, C and de novo expression of HLA-D in colorectal cancer. Int J Cancer 37: 179–184

    Google Scholar 

  • Morley DJ, Hodes JE, Calland J, Hodes ME (1983) Immunohistochemical demonstration of ribonuclease and amylase in normal and neoplastic parotid glands. Hum Pathol 14: 969–973

    PubMed  CAS  Google Scholar 

  • Morson BC (1974) Evolution of cancer of the colon and rectum. Cancer 34: 845–849

    PubMed  Google Scholar 

  • Morson BC, Konishi F (1980) Dysplasia in the colorectum. Clin Gastroenterol (Suppl I ) 9: 331–343

    Google Scholar 

  • Morson BC, Pang LSC (1967) Rectal biopsy as an aid to cancer control in ulcerative colitis. Gut 8: 423–434

    PubMed  CAS  Google Scholar 

  • Muenzel M (1976) Die Biochemie der menschlichen Speicheldrüsensekrete. Arch Oto-Rhino-Laryngol 213: 209–285

    Google Scholar 

  • Natali PG, De Martino C, Quaranta V, Bigotti A, Bellegrino MA, Ferrone S (1981) Changes in la-like antigen expression on malignant human cells. Immunogenetics 12: 409–413

    PubMed  CAS  Google Scholar 

  • Newcomb RW, Normansell D, Stanworth DR (1968) A structural study of human exocrine IgA globulin. J Immunol 101: 905–914

    PubMed  CAS  Google Scholar 

  • Nowell PC (1976) The clonal evolution of tumour cell populations. Acquired genetic lability permits stepwise selection of variant sublines and underlies tumour progression. Science 194: 23–28

    PubMed  CAS  Google Scholar 

  • Nowell PC (1986) Mechanisms of tumor progression. Cancer Res 46: 2203–2207

    PubMed  CAS  Google Scholar 

  • Petit JF, Jolles P (1963) Purification and analysis of human saliva lyzozyme. Nature Lond 200: 168–169

    PubMed  CAS  Google Scholar 

  • Poger ME, Hirsh BR, Lamm ME (1976) Synthesis of secretory component by colonic neoplasms. Am J Pathol 82: 327–338

    PubMed  CAS  Google Scholar 

  • Poulsen LO, Elling P, Brandt Sørensen F, Høedt-Rasmussen K (1986). HLA-DR expression and disease activity in ulcerative colitis. Scand J Gastroenterol 21: 364–368

    PubMed  CAS  Google Scholar 

  • Rankin FW, Broders AC (1928) Factors influencing prognosis in carcinoma of the rectum. Surg Gynecol Obstet 46: 660–667

    Google Scholar 

  • Regezi JA, Batsakis JG (1977) Histogenesis of salivary gland neoplasms. Otolaryngol Clin North Am 10: 297–307

    PubMed  CAS  Google Scholar 

  • Reitamo S, Klockars M, Raeste AM (1977) Immunohistochemical identification of lysozyme in the minor salivary glands of man. Archs Oral Biol 22: 515–519

    CAS  Google Scholar 

  • Reitamo S, Konttinen YT, Segerberg-Konttinen (1980) Distribution of lactoferrin in human salivary glands. Histochemistry 66: 285–291

    CAS  Google Scholar 

  • Remmele W, Heine M (1981) Pathologisch-anatomische Begutachtung Kolorectaler Karzinome unter prognostischen Gesichtspunkten. Med Welt 32: 771–777

    PubMed  CAS  Google Scholar 

  • Richman AB (1976) Immunofluorescence studies of benign and malignant human mammary tissue. J Natl Cancer Inst 57: 263–267

    PubMed  CAS  Google Scholar 

  • Riddell RH, Goldman H, Ranshoff DF et al. (1983) Dysplasia i inflammatory bowel disease: standarized classification with provisional clinical applications. Hum Pathol 14: 931–968

    PubMed  CAS  Google Scholar 

  • Rognum TO, Brandtzaeg P, Ørjasaeter H, Elgjo K, Hognestad J (1980a) Immunohistochemical study of secretory component, secretory IgA and carcinoembryonic antigen in large bowel carcinomas. Pathol Res Pract 170: 126–145

    PubMed  CAS  Google Scholar 

  • Rognum TO, Brandtzaeg P, Ørjasaeter H, Fausa O (1980b) Immunohistochemistry of epithelial cell markers in normal and pathological colon mucosa. Comparison of results based on routine formalin- and cold ethanol-fixation methods. Histochemistry 67: 7–21

    Google Scholar 

  • Rognum TO, Thorud E, Elgjo E, Brandtzaeg P, Orjasaeter H, Nygaard K (1982a) Large-bowel carcinomas with different ploidy, related to secretory component, IgA, and CEA in epithelium and plasma. Br J Cancer 45: 921–934

    Google Scholar 

  • Rognum TO, Elgjo K, Brandtzaeg P, Orjasaeter H, Bergan A (1982b) Plasma carcinoembryonic antigen concentrations and immunhistochemical patterns of epithelial marker antigens in patients with large bowel carcinoma. J Clin Pathol 35: 922–933

    PubMed  CAS  Google Scholar 

  • Rognum TO, Elgjo K, Fausa O, Brandtzaeg P (1982c) Immunohistochemical evaluation of carcinoembryonic antigen, secretory component, and epithelial IgA in ulcerative colitis with dysplasia. Gut 23: 123–133

    PubMed  CAS  Google Scholar 

  • Rognum TO, Fausa O, Brandtzaeg P (1982d) Immunohistochemical evaluation of carcinoembryonic antigen, secretory component, and epithelial IgA in tubular and villous large bowel adenomas with different grades of dysplasia. Scand J Gastroenterol 17: 341–348

    PubMed  CAS  Google Scholar 

  • Rognum TO, Brandtzaeg P, Thorud E (1983) Is heterogeneous expression of HLA-DR antigens and CEA along with DNA-profile variations evidence of phenotypic instability and clonal proliferation in human large bowel carcinomas? Br J Cancer 48: 453–551

    Google Scholar 

  • Rognum TO, Thorud E, Brandtzaeg P (1985) Preservation of cytometric DNA Distribution and epithelial marker expression after tumour progression of human large bowel carcinomas. Cancer 56: 1658–1666

    PubMed  CAS  Google Scholar 

  • Rognum TO, Brandtzaeg P, Elgjo K, Fause O (1987a) Heterogeneous expression of class II ( HLA-DR) determinants and secretory component related to dysplasia in ulcerative colitis. Br J Cancer 56

    Google Scholar 

  • Rognum TO, Thorud E, Lund E (1987b) Survival of large bowel carcinoma patients with different DNA ploidy. Br J Cancer (to be published )

    Google Scholar 

  • Rowe DJ, Beverly PCL (1984) Characterisation of breast cancer infiltrates using monoclonal antibodies to human leucocyte antigens. Br J Cancer 49: 149–159

    PubMed  CAS  Google Scholar 

  • Saito I, Teratini K, Inoue M, Saito A, Funatsu K, Moro I (1984) Immunohistochemical characterization of functional markers in human minor salivary gland tumors. J Oral Pathol 13: 525–534

    PubMed  CAS  Google Scholar 

  • Sanderson AR, Beverly PCL (1983) Interferon, β-2-microglobulin and immunoselection in the pathway to malignancy. Immunology Today 4: 211–213

    CAS  Google Scholar 

  • Sato M, Hayashi Y, Yoshida H, Yanagawa T, Yura Y, Nitta T (1984) Search for specific markers of neoplastic epithelial duct and myoepithelial cell lines established from human salivary gland and characterization of their growth in vitro. Cancer 54: 2959–2967

    PubMed  CAS  Google Scholar 

  • Scott H, Solheim BG, Brandtzaeg P, Thorsby E (1980) HLA-DR-like antigens in the epithelium of the human small intestine. Scand J Immunol 12: 77–82

    PubMed  CAS  Google Scholar 

  • Scott H, Brandtzaeg P, Solheim BG, Thorsby E (1981) Relation between HLA-DR-like antigen and secretory component ( SC) in jejunal epithelium of patients with coeliac disease or dermatitis herpatiformis. Clin Exp Immunol 44: 233–238

    Google Scholar 

  • Sehested M, Barfoed C, Krogdahl A, Bretlau P (1985) Immunohistochemical investigation of lysozyme, lactoferrin, α-1-antitrypsin, α -l-antichymotrypsin and ferritin in parotid gland tumours. J Oral Pathol 14: 459–465

    PubMed  CAS  Google Scholar 

  • Seifert G, Caselitz J (1983) Tumour markers in parotid gland carcinomas: Immunohistochemical investigations. Cancer Detect Prev 6: 119–130

    Google Scholar 

  • Selby WS, Janossy G, Goldstein G, Jewell DP (1981) T lymphocyte subsets in human intestinal mucosa: the distribution and relationship to MHC-derived antigens. Clin Exp Immunol 44: 453–458

    PubMed  CAS  Google Scholar 

  • Selby WS, Janossy G, Mason DY, Jewel DP (1983) Expression of HLA-DR antigen by colonic epithelium in inflammatory bowel disease. Clin Exp Immunol 53: 614–618

    PubMed  CAS  Google Scholar 

  • Sollid LM, Kvale D, Brandtzaeg P, Markussen G, Thorsby E (1987) Interferon-γ enhances expression of secretory component, the epithelial receptor for polymeric immunoglobulins. J Immunol 138: 4303–4306

    PubMed  CAS  Google Scholar 

  • Spandidos DA, Kerr IB (1984) Elevated expression of the human ras oncogene family in premalignant and malignant tumours of the colorectum. Br J Cancer 49: 681–688

    PubMed  CAS  Google Scholar 

  • Strominger JL, Orr HT, Robb RJ, Pasham P, Ploegh HL, Mann OL, Bilofsky H, Saroft HA, Wytt, Kabat EA (1980) An evaluation of the significance of amino acid sequence homologies in human histocompatibility antigens ( HLA-A and HLA-B) with immunoglobulins and other proteins, using relatively short sequences. Scand J Immunol 11: 537–592

    Google Scholar 

  • Syrjanen KJ, Hjelt LH (1978) Tumour-host relationship in colorectal carcinoma. Dis Colon Rect 21: 29–36

    CAS  Google Scholar 

  • Thompson AS, Bryant HC (1950) Histogenesis of papillary cystadenoma lymphomatosum ( Warthin’s tumor) of the parotid salivary gland. Am J Pathol 26: 807–829

    Google Scholar 

  • Thoresen S, Thorsen T, Tangen M, Hartveit F (1982) Oestrogen and progesterone receptor content and the distribution of histological grade in breast cancer. Breast Cancer Res Treatment 2: 251–255

    CAS  Google Scholar 

  • Thrane PS, Brandtzaeg P (1987a) Distribution of MHC class I and II molecules in fetal, postnatal and normal and inflamed adult major and minor salivary glands. Submitted

    Google Scholar 

  • Thrane PS, Brandtzaeg P (1987b) Presumably activated (HLA-DR positive) T cells occur adjacent to HLA-DR negative duct epithelium in Warthin’s tumor of the salivary gland. Abstract. Scand J Immunol 24: 480

    Google Scholar 

  • Thrane PS, Rognum TO, Huitfeldt HS, Brandzaeg P (1987a) The distribution of HLA-DR determinants, secretory component (SC), amylase, lysozyme, IgA, IgM, and IgD in fetal and postnatal salivary glands. Adv Exp Med Biol (to be published )

    Google Scholar 

  • Thrane PS, Sollid LM, Huitfeldt HS, Brandtzaeg P (1987b) Paired immunofluorescence marker study of various cell populations in pleomorphic adenomas.

    Google Scholar 

  • Submitted Thrane PS, Sollid LM, Brandtzaeg P (1987c) HLA-DR-positive dendritic histiocytic cells in pleomorphic adenomas. Immunohistochemical characterization and positive selection of DR-positive cells by immunomagnetic beads.

    Google Scholar 

  • Submitted Tomasi TB, Tan EM, Solomon A, Prendergast RA (1965) Characteristics of an immune system common to certain external secretions. J Exp Med 121: 101–124

    PubMed  CAS  Google Scholar 

  • Toto P, Hsu DJ (1985) Product definition of pleomorphic adenoma of minor salivary glands. J Oral Pathol 14: 818–832

    PubMed  CAS  Google Scholar 

  • Umpleby HC, Heinemann D, Symes MO, Williamson RCN (1985) Expression of histocompatibility antigens and characterization of mononuclear cell infiltrates in normal and neoplastic colorectal tissues of humans. J Natl Cancer Inst 74: 1161–1168

    PubMed  CAS  Google Scholar 

  • Valnes K, Brandtzaeg P (1984) Paired indirect immunoenzyme staining with primary antibodies from the same species. Application of horseradish peroxidase and alkaline phosphatase as sequential labels. Histochem J 16: 477–487

    Google Scholar 

  • Valnes K, Brandtzaeg P, Hanssen LE, Stave R, Larsen S, Londong W (1983) Quantitation of immunoglobulin- and peptide hormone-producing cells in gastrointestinal mucosa. Comparison of direct immunofluorescence and unlabelled antibody peroxidase-antiperoxidase method. Histochem J 15: 1011–1020

    Google Scholar 

  • Wallich R, Bulbuc N, Hammerling GJ, Katzav S, Segal S, Feldman M (1985) Abrogation of metastatic properties of tumour cells by de novo expression of H-2K antigens following H-2 gene transfection. Nature 315: 301–305

    PubMed  CAS  Google Scholar 

  • Warner TFCS, Seo IS, Azen EA, Hafez GR, Zarling TA (1985) Immunocytochemistry of acinic cell carcinomas and mixed tumours of salivary glands. Cancer 56: 2221–2227

    PubMed  CAS  Google Scholar 

  • Weisz-Carrington P, Poger ME, Lamm ME (1976) Secretory immunoglobulins in colonic neoplasms. Am J Pathol 85: 303–316

    PubMed  CAS  Google Scholar 

  • Whitwell HL, Huges HPA, Moore M, Ahmed A (1984) Expression of major histocompatibility antigens and leucocyte infiltration in benign and malignant human breast disease. Br J Cancer 49: 161–172

    PubMed  CAS  Google Scholar 

  • Wolley RG, Schreiber K, Koss LG, Kara M, Sherman A (1982) DNA distribution in human colon carcinomas and its relationship to clinical behaviour. J Natl Cancer Inst 69: 15–22

    PubMed  CAS  Google Scholar 

  • Zinkernagel RM, Doherty PC (1979) MHC cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T cell restriction-specificity, function and responsiveness. Adv Immunol 27: 51–177

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Rognum, T.O., Thrane, P.S., Korsrud, F.R., Brandtzaeg, P. (1987). Epithelial Tumor Markers: Special Markers of Glandular Differentiation. In: Seifer, G. (eds) Morphological Tumor Markers. Current Topics in Pathology, vol 77. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71356-9_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-71356-9_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71358-3

  • Online ISBN: 978-3-642-71356-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics