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Histamine and Allergic Diseases

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New Trends in Allergy II

Abstract

Although known for almost 80 years, histamine (H) (β-imidazolylethylamine) still remains a fascinating substance for many researchers. In spite of great progress in knowledge of pharmacology and release mechanisms as well as the discovery of other potent mediators, the definition of the physiological role of histamine in health and disease remains incomplete. The role of H — among others — as mediator of immediate-type hypersensitivity diseases (both allergic and pseudo-allergic in origin) is rather well established. This proinflammatory effect involves predominantly H1 receptors on mucosal cells, smooth muscle and vascular endothelium. Similarly well-defined is the H2-mediated role of H in gastric acid secretion. Less well defined is the clinical relevance of cardiac H1 and H2 receptors (atrial H1 receptors mediating negative dromotropic effects, while ventricular tachycardia is mediated by H2 receptors) as well as the role of H as neurotransmitter in the human brain.

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  1. Dermatologische Klinik und Poliklinik, der Ludwig-Maximilians-Universität München, 8000, Munich, Federal Republic of Germany

    J. Ring, F. Sedlmeier, D. von der Helm, T. Mayr, U. Walz, H. Ibel, H. Riepel & B. Przybilla

  2. II. Medizinische Klinik, der Technischen Universität München, 8000, Munich, Federal Republic of Germany

    H.-J. Reimann

  3. Kinderpoliklinik, der Ludwig-Maximilians-Universität München, 8000, Munich, Federal Republic of Germany

    W. Dorsch

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    Johannes Ring (Head: Prof. Dr. Dr. hc. O. Braun-Falco) & Günter Burg (Head: Prof. Dr. Dr. hc. O. Braun-Falco) (Head: Prof. Dr. Dr. hc. O. Braun-Falco) &  (Head: Prof. Dr. Dr. hc. O. Braun-Falco)

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Ring, J. et al. (1986). Histamine and Allergic Diseases. In: Ring, J., Burg, G. (eds) New Trends in Allergy II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71316-3_7

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