Skip to main content
SpringerLink
Log in

Intensive Induction and Consolidation Chemotherapy for Adults and Children with Acute Myeloid Leukaemia (AML) Joint AML Trial 1982–1985

  • Conference paper
Acute Leukemias

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 30))

Abstract

Complete remission (CR) can now be obtained in approximately 75% of patients presenting with AML [1–4]. It is not certain, however, whether subsequent intensive therapy (“consolidation”) will prolong remission duration in patients achieving CR [5]. Furthermore, if consolidation therapy is important, the optimum number of courses remains to be established. The role of allogeneic bone marrow transplantation (BMT) in such patients is not clear. Although it seems that relapse rates after BMT are lower than those observed after chemotherapy, overall survival in the former group may not be superior due to increased deaths following transplant-related complications [6, 7].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Preisler HD, Rustum Y, Henderson ES, et al. (1979) Treatment of acute non-lymphocytic leukemia: use of anthracyclin — cytosine arabinoside induction therapy and comparison of two maintenance regimens. Blood 53: 455–464

    PubMed  CAS  Google Scholar 

  2. Gale RF, Foon KA, Cline MJ, et al. (1981) Intensive chemotherapy for acute myelogenous leukaemia. Ann Intern Med 94: 753–757

    PubMed  CAS  Google Scholar 

  3. Rai KR, Holland JR, Glidewell OJ, et al. (1981) Treatment of acute myelocytic leukemia: a study by Cancer and Leukemia Group B. Blood 58: 1203–1212

    PubMed  CAS  Google Scholar 

  4. Weinstein HJ, Mayer RJ, Rosenthal DS, et al. (1983) Chemotherapy for acute myelogenous leukemia in children and adults: VAPA update. Blood 62: 315–319

    Google Scholar 

  5. Wolff SN, Marion J, Stein RS, et al. (1985) High-dose cytosine arabinoside and daunorubicin as consolidation therapy for acute nonlymphocytic leukemia in first remission: a pilot study. Blood 65: 1407–1411

    PubMed  CAS  Google Scholar 

  6. Appelbaum FR, Dahlberg S, Thomas ED, et al. (1984) Bone marrow transplantation or che- motherapy after remission induction for adults with acute nonlymphoblastic leukemia: a pro- Ann Intern Med

    Google Scholar 

  7. Champlin RE, Ho WG, Gale RP, et al. (1985) Treatment of acute myelogenous leukemia: a prospective controlled trial of bone marrow transplantation versus consolidation chemotherapy. Ann Intern Med 102: 285–291

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. MRC Leukaemia Unit, Hammersmith Hospital, London, USA

    R. E. Marcus, D. Catovsky, J. M. Goldman & D. A. G. Galton

  2. Department of Haematology, Royal Free Hospital, London, USA

    H. G. Prentice & A. V. Hoffbrand

Authors
  1. R. E. Marcus
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Catovsky
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. G. Prentice
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. C. Newland
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J. M. Chessells
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. R. F. Stevens
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. I. M. Hann
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. J. M. Goldman
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. A. V. Hoffbrand
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. D. A. G. Galton
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Departments of Internal Medicine and Pediatrics, University of Münster, Albert-Schweitzer-Strasse 33, D-4400, Münster, Federal Republic of Germany

    T. Büchner , G. Schellong , W. Hiddemann , D. Urbanitz  & J. Ritter , , ,  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Marcus, R.E. et al. (1987). Intensive Induction and Consolidation Chemotherapy for Adults and Children with Acute Myeloid Leukaemia (AML) Joint AML Trial 1982–1985. In: Büchner, T., Schellong, G., Hiddemann, W., Urbanitz, D., Ritter, J. (eds) Acute Leukemias. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71213-5_56

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-71213-5_56

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-16556-9

  • Online ISBN: 978-3-642-71213-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation