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Lesions of the Male and Female External Genitalia Associated with Human Papillomaviruses

  • Chapter
Papillomaviruses and Human Disease

Abstract

Genital warts (condylomata acuminata), the most common benign genital tumor in both sexes, have been considered for many centuries to be related to venereal diseases such as gonorrhea and syphilis (Oriel 1981). Until some 15 years ago condylomata acuminata were thought to be trivial lesions of little importance to the patient. There is no doubt today that these lesions are sexually transmissible and, in view of the striking increase in prevalence, they are recognized as one of the most important sexually transmitted diseases (STD). According to the Center for Disease Control (United States of America) genital warts are currently three times more common than genital herpes. In 1984 there were approximately 1 million new cases in the United States of America (Chuang et al. 1984). Human papillomaviruses (HPV) have been identified as the agents responsible for genital warts (Gissmann and zur Hausen 1980). The importance of HPV infection increased still further because of the recognized linkage between HPV and the development of malignant and premalignant conditions affecting the cervix, vagina, vulva, penis, and anus (zur Hausen 1982; Gissmann 1984) (Table 1). Another disease wherein HPV plays a significant role is epidermodysplasia verruciformis (EV). There are well-documented case reports on the malignant conversion of skin warts in this rare disorder.

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References

  • Abell MR, Gosling JR (1961) Intraepithelial and infiltrative carcinoma of the vulva: Bowen’s type. Cancer 14: 318–329

    PubMed  CAS  Google Scholar 

  • Ackerman LV (1948) Verrucous carcinoma of the oral cavity. Surgery 23: 670–678

    PubMed  CAS  Google Scholar 

  • Adam E, Kaufman RH, Adler-Storthz K, Melnick JL, Dreesman GR (1986) A prospective study of association of herpes simplex virus and human papillomavirus infection with cervical neoplasia in women exposed to diethylstilbestrol in utero. Int J Cancer 35: 19–26

    Google Scholar 

  • Adler-Storthz K, Newland JR, Tessin BA, Yeudall WA, Shillitoe EJ (1986) HPV2 DNA in oral verrucous carcinoma. International workshop on papillomaviruses. Cold Spring Harbor, September

    Google Scholar 

  • Aird I, Johnson HD, Lennox B, Stansfeld AG (1954) Epithelioma cuniculatum. A variety of squamous carcinoma, peculiar to the foot. Br J Surg 42: 245–250

    PubMed  CAS  Google Scholar 

  • Barrett TJ, Silbar BH, McGinley JP (1954) Genital warts, a venereal disease. JAMA 154: 333–334

    CAS  Google Scholar 

  • Beaudenon S, Kremsdorf D, Croissant O, Jablonska S, Wain-Hobson S, Orth G (1986) A novel type of human papillomavirus associated with genital neoplasias. Nature 321: 246–249

    PubMed  CAS  Google Scholar 

  • Benedet JL, Sanders BH (1984) Carcinoma in situ of the vagina. Am J Obstet Gynecol 148: 695–700

    PubMed  CAS  Google Scholar 

  • Berg JW, Lampe JG (1981) High-risk factors in gynecologic cancer. Cancer 48: 429–441

    PubMed  CAS  Google Scholar 

  • Berger BW, Hori Y (1978) Multicentric Bowen’s disease of the genitalia. Spontaneous regression of lesions. Arch Dermatol 114: 1698–1699

    PubMed  CAS  Google Scholar 

  • Bergeron C, Naghasfar Z, Shah K, Fu Y, Ferenczy A (1986) Human papillomavirus type 16 in intraepithelial neoplasia (bowenoid papulosis) and coexistent invasive carcinoma of the vulva. International workshop on papillomaviruses, Cold Spring Harbor, September

    Google Scholar 

  • Böcker W, Stegner HE (1981) Praneoplasien der Vulva. Arch Gynecol 232: 1–12

    Google Scholar 

  • Boshart M, Gissmann L, Ikenberg H, Kleinheinz A, Scheurlen W, zur Hausen H (1984) A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines from cervical cancer. Int J Cancer 3: 1151–1157

    CAS  Google Scholar 

  • Boxer RJ, Skinner DO (1977) Condylomata acuminata and squamous cell carcinoma. Urology 9: 72–78

    PubMed  CAS  Google Scholar 

  • Bracken RB (1981) Genitourinary cancer. Cancer Chemother 2: 199–242

    Google Scholar 

  • Brandsma JL, Steinberg BM, Abramson AL, Winkler B (1986) Presence of human papillomavirus type 16 related sequences in verrucous carcinoma of the larynx. Cancer Res 46: 2185–2188

    PubMed  CAS  Google Scholar 

  • Braun L, Farmer ER, Shah KV (1983) Immunoperoxidase localization of papillomavirus antigen in cutaneous warts and bowenoid papulosis. J Med Virol 12: 187–193

    PubMed  CAS  Google Scholar 

  • Buschke A, Lowenstein L (1925) Ober carcinomahnliche Condylomata acuminata des Penis. Klin Wochenschr 4: 1726–1728

    Google Scholar 

  • Campion MJ, Singer A, Clarkson PK, McCance DJ (1985) Increased risk of cervical neoplasia in consorts of men with penile condylomata acuminata. Lancet i: 943–946

    Google Scholar 

  • Chief Medical Officer of the Department of Health and Social Security (1983) Sexually transmitted diseases. Br J Vener Dis 59: 134–137

    Google Scholar 

  • Chuang TY, Perry HO, Kurland LT, Ilstrup DM (1984) Condyloma acuminatum in Rochester, Minn, 1950–1978: 1. Epidemiology and clinical features. Arch Dermatol 120: 469–475

    PubMed  CAS  Google Scholar 

  • Coggin JR, zur Hausen H (1979) Workshop on papillomaviruses and cancer. Cancer Res 39: 545–546

    Google Scholar 

  • Crum CP, Braun LA, Shah K, Fu YS, Levine RS, Fenoglio CM, Richart RM, Townsend DE (1982) Vulvar intraepithelial neoplasia: correlation of nuclear DNA content and the presence of a human papillomavirus (HPV) structural antigen. Cancer 49: 468–471

    PubMed  CAS  Google Scholar 

  • Dejong AR, Weiss JC, Brent RL (1982) Condylomata acuminata in children. Am J Dis Child 136: 704–706

    CAS  Google Scholar 

  • Del Mistro A, Vallejos H, Kleinhaus S, Braunstein JD, Halwer M, Koss LG (1986) HPV types in condylomata acuminata in prepubertal children. International workshop on papillomaviruses, Cold Spring Harbor, September

    Google Scholar 

  • De Villiers EM, Schneider A, Gross G, zur Hausen H (1986a) Analysis of benign and malignant urogenital tumors for human papillomavirus infection by labelling cellular DNA. Med Microbioi Immunol 174: 281–284

    Google Scholar 

  • De Villiers EM, Weidauer H, Otto H, zur Hausen H (1986b) Papillomavirus DNA in human tongue carcinomas. Int J Cancer 36: 575–577

    Google Scholar 

  • Di Paola GR, Gomez Rueda-Leverone H, Belardi MG, Vighi S (1982) Vulvar carcinoma in situ: a report of 28 cases. Gynecol Oncol 14: 236–241

    PubMed  Google Scholar 

  • Draper GJ, Cook GA (1983) Changing pattern of cervical cancer rates. Br Med J 287: 510–514

    CAS  Google Scholar 

  • Dürst M, Gissmann L, Ikenberg H, zur Hausen H (1983) A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsies from different geographical regions. Proc Natl Acad Sci USA 80: 3812–3815

    PubMed  Google Scholar 

  • Ferenczy A, Mitao M, Nagai N, Silverstein SJ, Crum CP (1985) Latent papillomavirus and recurring genital warts. N Engl J Med 313: 784–788

    PubMed  CAS  Google Scholar 

  • Franklin EW, Rutledge FD (1972) Epidemiology of epidermoid carcinoma of the vulva. J Obstet Gynecol 39: 165–172

    Google Scholar 

  • Friedrich EG (1972) Reversible vulvar atypia. A case report. Obstet Gynecol 39: 173–181

    PubMed  Google Scholar 

  • Friedrich EG (1983) Vulvar disease, 2nd edn. Saunders, Philadelphia

    Google Scholar 

  • Gissmann L, zur Hausen H (1980) Partial characterization of viral DNA from human genital warts (condylomata acuminata). Int J Cancer 25: 605–609

    PubMed  CAS  Google Scholar 

  • Gissmann L, de Villiers EM, zur Hausen H (1982) Analysis of human genital warts (condylomata acuminata) and other genital tumours for human papillomavirus type 6 DNA. Int J Cancer 29: 143–146

    PubMed  CAS  Google Scholar 

  • Gissmann L, Wolnik L, Ikenberg H, Koldovsky U, Schnurch HG, zur Hausen H (1983) Human papillomavirus types 6 and 11 DNA sequences in genital and laryngeal papillomas and in some cervical cancers. Proc Natl Acad Sci USA 80: 560–563

    PubMed  CAS  Google Scholar 

  • Gissmann L, Boshart M, Durst M, Ikenberg H, Wagner D, zur Hausen H (1984) Presence of human papillomavirus (HPV) DNA in genital tumors. J Invest Dermatol [Suppl] 83: 26–28

    Google Scholar 

  • Gissmann L (1984) Papillomaviruses and their association with cancer in animals and in man. Cancer Surv 3: 161–181

    Google Scholar 

  • Gissmann L, Gross G (1985) Association of HPV with human genital tumors. Clin Dermatol 3: 124–129

    PubMed  CAS  Google Scholar 

  • Gissmann L, Schneider A (1986) Human papillomavirus in preneoplastic and neoplastic genital lesions. In: zur Hausen H, Peto R (eds) Origins of female genital cancer: virological and epidemiological aspects. Banbury Report, Cold Spring Harbor, New York, pp 217–224

    Google Scholar 

  • Green M, Brackmann KH, Sanders PR, Lowenstein PM, Freel JH, Eisinger M, Switlyk SA (1982) Isolation of a human papillomavirus from a patient with epidermodysplasia verruciformis: presence of related viral DNA genomes in human urogenital tumors. Proc Natl Acad Sci USA 79: 4437–4441

    PubMed  CAS  Google Scholar 

  • Gross G, Pfister H, Hagedorn M, Gissmann L (1982) Correlation between human papillomavirus (HPV) type and histology of warts. J Invest Dermatol 78: 160–164

    PubMed  CAS  Google Scholar 

  • Gross G, Ikenberg H, Gissmann L, Hagedorn M (1985a) Papillomavirus infection of the anogenital region: correlation between histology, clinical picture and virus type. Proposal of a new nomenclature. J Invest Dermatol 85: 147–152

    PubMed  CAS  Google Scholar 

  • Gross G, Hagedorn M, Ikenberg H, Rufli T, Dahlet C, Grosshans E, Gissmann L (1985b) Bowenoid papulosis. Presence of human papillomavirus (HPV) structural antigens and of HPV 16-related DNA sequences. Arch Dermatol 121: 858–863

    PubMed  CAS  Google Scholar 

  • Gross G, Schneider A, Hauser-Brauner B, Wagner D, Ikenberg H, Gissmann L (1985c) Transmission of genital papillomavirus infections: a study of sexual partners. J Cell Biochem [Suppl] 96: 71

    Google Scholar 

  • Gross G, Ikenberg H, de Villiers EM, Schneider A, Wagner D, Gissmann L (1986) Bowenoid papulosis: a venereally transmissible disease as reservoir for HPV 16. In: zur Hausen H, Peto R (eds) Origins of female genital cancer: Virological and epidemiological aspects. Banbury Report, Cold Spring Harbor, New York, pp 149–165

    Google Scholar 

  • Guillet GY, Braun L, Masse R, Altimos J, Geniaux M, Texier L (1984) Bowenoid papulosis. Demonstration of human papillomavirus (HPV) with anti-HPV immune serum. Arch Dermatol 120: 514–516

    PubMed  CAS  Google Scholar 

  • Hammond JG, Monagham JM (1983) Multicentric carcinoma of the female lower genital tract. Br J Obstet Gynecol 90: 557–561

    CAS  Google Scholar 

  • Hauser B, Gross G, Schneider A, de Villiers EM, Gissmann L, Wagner D (1985) HPV 16 related bowenoid papulosis (letter). Lancet ii: 106

    Google Scholar 

  • Herbst AC, Ulfelder H, Poskauzer DC (1971) Adenocarcinoma of the vagina: association of maternal stilbestrol therapy with tumor appearance in young women. N Engl J Med 284: 878–881

    PubMed  CAS  Google Scholar 

  • Ikenberg H, Gissmann L, Gross G, Grußendorf-Conen EI, zur Hausen H (1983) Human papillomavirus type-16-related DNA in genital Bowen’s disease and in bowenoid papulosis. Int J Cancer 32: 563–565

    PubMed  CAS  Google Scholar 

  • Jenson AB, Rosenthal JD, Olson C, Pass F, Lancaster WD, Shah K (1980) Immunologic relatedness of papillomaviruses from different species. JNCI 64: 495–500

    PubMed  CAS  Google Scholar 

  • Jimerson GK, Merrill JA (1970) Multicentric squamous malignancy involving both cervix and vulva. Cancer 26: 150–153

    PubMed  CAS  Google Scholar 

  • Judge JR (1969) Giant condylomatum involving vulva and rectum. Arch Pathol 88: 46–49

    PubMed  CAS  Google Scholar 

  • Judson FN, Penley KA, Robinson ME, Smith JK (1980) Comparative prevalence rates of sexually transmitted diseases in heterosexual and homosexual men. Am J Epidemiol 112: 836–843

    PubMed  CAS  Google Scholar 

  • Kanbour AI, Klionsky B, Murphy AI (1974) Carcinoma of the vagina following cervical cancer. Cancer 34: 1838–1841

    PubMed  CAS  Google Scholar 

  • Kimura S, Hirai R, Harada R, Nagashima M (1978) So-called multicentric Bowen’s disease. Report of a case and a possible etiologic role of human papillomavirus. Dermatologica 157: 229–237

    PubMed  CAS  Google Scholar 

  • Kinghorn GR (1978) Genital warts; incidence of associated genital infections. Br J Dermatol 99: 405–409

    PubMed  CAS  Google Scholar 

  • Koss LG, Durfee GR (1956) Unusual patterns of squamous epithelium of the uterine cervix. Cytologic and pathologic study of koilocytotic atypia. Ann NY Acad Sci 63: 1245–1261

    PubMed  CAS  Google Scholar 

  • Krzyzek RA, Watts SL, Anderson DL, Faras AJ, Pass F (1980) Anogenital warts contain several distinct species of human papillomavirus. J Virol 36: 236–244

    PubMed  CAS  Google Scholar 

  • Lee SH, McGregor DH, Kuzier MN (1981) Malignant transformation of perianal condyloma acuminatum. Dis Colon Rectum 24: 462–467

    PubMed  CAS  Google Scholar 

  • Lloyd KM (1970) Multicentric pigmented Bowen’s disease of the groin. Arch Dermatol 101: 48–51

    PubMed  CAS  Google Scholar 

  • Lorincz AI, Lancaster WD, Temple GF (1985) Detection and characterization of a new type of human papillomavirus. J Cell Biochem [Suppl] 9c: 75

    Google Scholar 

  • Marino AW Jr (1964) Proctologic lesions in male homosexuals. Dis Colon Rectum 7: 121–125

    PubMed  Google Scholar 

  • Martinez I (1969) Relationship of squamous cell carcinoma of the cervix uteri to squamous cell carcinoma of the penis. Cancer 24: 777–780

    PubMed  CAS  Google Scholar 

  • McCance DJ (1986) Human papillomaviruses and cancer. Biochim Biophys Acta 823: 195–205

    PubMed  CAS  Google Scholar 

  • McCance DJ, Singer A (1986) The importance of HPV infections in the male and in the male genital tract and their relationship to cervical neoplasia. In: zur Hausen H, Peto R (eds) Origins of female genital cancer: histological and epidemiological aspects. Banbury Report, Cold Spring Harbor, New York, pp 311–319

    Google Scholar 

  • Meisels A, Fortin R (1976) Condylomatous lesions of cervix and vagina: I. Cytologic patterns. Acta Cytol (Baltimore) 20: 505–509

    CAS  Google Scholar 

  • Meisels A, Fortin R, Roy M (1977) Condylomatous lesions of cervix: II. Cytologic, colposcopic and histopathologic study. Acta Cytol (Baltimore) 21: 379–390

    CAS  Google Scholar 

  • Meisels A, Roy M, Fortier M, Morin C, Casas-Cordero M, Shah KV, Turgeon H (1981) Human papillomavirus infection of the cervix. The atypical condyloma. Acta Cytol (Baltimore) 25: 7–16

    CAS  Google Scholar 

  • Obalek S, Jablonska S, Orth G (1985) HPV associated intraepithelial neoplasia of external genitalia. Clin Dermatol 3: 104–113

    PubMed  CAS  Google Scholar 

  • Oriel JD (1971a) Natural history of genital warts. Br J Vener Dis 47: 1–13

    PubMed  CAS  Google Scholar 

  • Oriel JD (1971b) Anal warts and anal coitus. Br J Vener Dis 47: 373–376

    PubMed  CAS  Google Scholar 

  • Oriel JD (1981) Genital warts. Sex Transm Dis 8: 326–329

    CAS  Google Scholar 

  • Ostrow R, Manias D, Clark B, Okagaki T, Twiggs L, Faras A (1986) The analysis of malignant tumors of the vulva, vagina and cervix for HPV DNA. International workshop on papillomaviruses, Cold Spring Harbor, September

    Google Scholar 

  • Perez CA, Arneson AN, Galakatos A, Samanth HR (1973) Malignant tumors of the vagina. Cancer 31: 36–41

    PubMed  CAS  Google Scholar 

  • Peters RK, Mack TM, Bernstein L (1984) Parallels in the epidemiology of selected anogenital carcinomas. JNCI 72(3): 609–615

    PubMed  CAS  Google Scholar 

  • Petrucco DM, Seamark RF, Holmes K, Forbes IJ, Symons RG (1976) Changes in lymphocyte function during pregnancy. Br J Obstet Gynecol 83: 245–250

    CAS  Google Scholar 

  • Pfister H, zur Hausen H (1978) Seroepidemiological studies of human papillomavirus (HPV I) infections. Int J Cancer 21: 161–165

    PubMed  CAS  Google Scholar 

  • Pfister H (1984) Biology and biochemistry of papillomaviruses. Rev Physiol Biochem Pharmacol 99: 111–181

    PubMed  CAS  Google Scholar 

  • Pinkus H, Mehregan AH (1976) A guide to dermatohistopathology, 2nd edn. Appleton-CenturyCrofts, New York

    Google Scholar 

  • Powell L (1978) Condyloma acuminatum. Recent advances in development, carcinogenesis and treatment. Clin Obstet Gynecol 21: 1061–1079

    PubMed  Google Scholar 

  • Purola E, Savia E (1977) Cytology of gynaecologic condyloma acuminata. Acta Cytol (Baltimore) 21: 26–31

    CAS  Google Scholar 

  • Roberts A (1982) Cervical cytology in England and Wales. 1965–1980. Health Trends 14: 41–43

    Google Scholar 

  • Schneider A, Kraus H, Schuhmann R, Gissmann L (1985) Papillomavirus infection of the lower genital tract: detection of viral DNA in gynecological swabs. Int J Cancer 35: 443–448

    PubMed  CAS  Google Scholar 

  • Schneider V, Kay S, Lee HM (1983) Immunosuppression as a high-risk factor in the development of condyloma acuminatum and squamous neoplasia of the cervix. Acta Cytol (Baltimore) 27: 220–224

    CAS  Google Scholar 

  • Segi M (1977) Graphic presentation of cancer incidence by site and by area and population. Segi Institute for Cancer Epidemiology, Nagoya

    Google Scholar 

  • Shingleton HM, Fowler WC, Palumbo L, Koch GG (1970) Carcinoma of the vulva: influence of radical operation on cure rate. Obstet Gynecol 35: 1–8

    PubMed  CAS  Google Scholar 

  • Shokri-Tabibzadeh S, Koss LG, Molinar J, Romney MD (1981) Association of human papillomavirus with neoplastic processes in the genital tract of four women with impaired immunity. Gynecol Oncol 12: S129–S140

    PubMed  CAS  Google Scholar 

  • Sillmann F, Stanek A, Sedlis A, Rosenthal J, Lanks KW, Buchhagen D, Nicastri A, Boyce J (1984) The relationship between human papillomavirus and lower genital intraepithelial neoplasia in immunosuppressed women. Am J Obstet Gynecol 150: 300–308

    Google Scholar 

  • Singer A (1973) A male factor in aetiology of cervical cancer? Oxford Med School Gaz 25: 18–19

    Google Scholar 

  • Singer A, Reid BL, Coppleson M (1976) A hypothesis: the role of the high-risk male in the etiology of cervical carcinoma. Am J Obstet Gynecol 126: 110

    PubMed  CAS  Google Scholar 

  • Smotkin D, Fu YS, Wettstein FO (1986) Distribution of human papillomavirus types 16 and 18 in lesions of the female lower genital tract. International workshop on papillomaviruses. Cold Spring Harbor, September

    Google Scholar 

  • Steinberg BM, Topp WC, Schneider PS, Abramson AL (1983) Laryngeal papillomavirus infection during clinical remission. N Engl J Med 308: 1261–1264

    PubMed  CAS  Google Scholar 

  • Stumpf PG (1980) Increasing occurrence of condylomata acuminata in premenarchal children. Obstet Gynecol 56: 262–264

    PubMed  CAS  Google Scholar 

  • Syrjänen KJ, Vayrynen M, Castren O, Yiskoski M, Mantyjarri R, Pyrhonen S, Saarikoski S (1984) Sexual behaviour of females with human papillomavirus lesions in the uterine cervix. Br J Vener Dis 60: 243–248

    PubMed  Google Scholar 

  • Villa LL, Lopes A (1986) Human papillomavirus. DNA sequences in penile carcinomas in Brazil. Int J Cancer 37: 853–855

    PubMed  CAS  Google Scholar 

  • Wade TR, Kopf AW, Ackerman AB (1978) Bowenoid papulosis of the penis. Cancer 42: 1890–1903

    PubMed  CAS  Google Scholar 

  • Wade TR, Kopf AW, Ackerman AB (1979) Bowenoid papulosis in the genitalia. Arch Dermatol 115: 306–308

    PubMed  CAS  Google Scholar 

  • Wagner D, Ikenberg H, Boehm N, Gissmann L (1984) Identification of human papillomavirus in cervical swabs by deoxyribunucleic acid in situ hybridization. Obstet Gynecol 64: 767–772

    PubMed  CAS  Google Scholar 

  • Walker PG, Singer A, Dyson J, Oriel JD (1983) Natural history of cervical epithelial abnormalities in patients with vulval warts. Br J Vener Dis 159: 327–329

    Google Scholar 

  • Waterhouse J, Muir C, Correa P, Powell J (1982) Cancer in five continents, vol 4. International Agency for Research on Cancer, Lyon

    Google Scholar 

  • Weed JC, Lozier C, Daniel SJ (1983) Human papillomavirus in multifocal invasive female genital tract malignancy. Obstet Gynecol 62: 583–587

    Google Scholar 

  • Woodruff JD (1981) Carcinoma in situ of the vagina. Clin Obstet Gynecol 2: 485–488

    Google Scholar 

  • Woodruff JD, Hildebrandt EE (1958) Carcinoma in situ of the vulva. Obstet Gynecol 12: 414–424

    PubMed  CAS  Google Scholar 

  • Woodruff JD, Julian C, Puray T, Mermut S, Katayama P (1983) The contemporary challenge of carcinoma in situ of the vulva. Am J Obstet Gynecol 115: 667–684

    Google Scholar 

  • Zachow KR, Ostrow RS, Bender M, Watts S, Okagaki T, Pass F, Faras AJ (1982) Detection of human papillomavirus DNA in anogenital neoplasias. Nature 300: 771–773

    PubMed  CAS  Google Scholar 

  • zur Hausen H (1977) Human papillomaviruses and their possible role in squamous cell carcinomas. CUff Top Microbiol Immunol 78: 1–30

    Google Scholar 

  • zur Hausen H (1982) Human genital cancer: synergism between two virus infections or synergism between a virus infection and initiating events. Lancet ii: 1370–1372

    Google Scholar 

  • zur Hausen H (1986) Intracellular surveillance of persisting viral infections. Human genital cancer results from deficient cellular control of papillomavirus gene expression. Lancet i: 489–491

    Google Scholar 

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  1. G. Gross
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Editors and Affiliations

  1. Laboratory of Pathology & Cancer Research, Finnish Cancer Society, Kiekkotie 2, SF-70200, Kuopio, Finland

    Kari J. Syrjänen M.D. (Director) (Director)

  2. Institut für Virusforschung, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-6900, Heidelberg, West Germany

    Lutz Gissmann (Prof. Dr. rer. nat.) (Prof. Dr. rer. nat.)

  3. Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 East 210th Street, 10467, Bronx, New York, USA

    Leopold G. Koss M.D. (Professor and Chairman) (Professor and Chairman)

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Gross, G. (1987). Lesions of the Male and Female External Genitalia Associated with Human Papillomaviruses. In: Syrjänen, K.J., Gissmann, L., Koss, L.G. (eds) Papillomaviruses and Human Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71097-1_8

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  • DOI: https://doi.org/10.1007/978-3-642-71097-1_8

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