Abstract
Ciclosporin (CyA) is a potent immunosuppressive agent which acts selectively upon the immune response by inhibition of the lymphokine cascade, thus inhibiting cell-cell communication [1]. In addition, augmentation of the inflammatory response is attenuated by blockade of macrophage migration inhibition factor (MIF) and macrophage arming factor (MAF), limiting the delayed-type hypersensitivity response and immunologically nonspecific tissue injury [2]. By virtue of its efficacy and immunologic specificity, CyA is employed extensively in organ transplantation, and also appears to be of major potential importance in the area of auto-immunity.
Supported in part by grants from the Medical Research Council of Canada, the Ivey Foundation, and the Kidney Foundation of Canada
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© 1985 Sandoz Ltd, Basle
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Keown, P.A., Stiller, C.R., Stawecki, M., McMichael, J., Howson, W. (1985). Pharmacokinetics and Interactions of Ciclosporin. In: Schindler, R. (eds) Ciclosporin in Autoimmune Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70607-3_6
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DOI: https://doi.org/10.1007/978-3-642-70607-3_6
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