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HLA-DP: Current Status

  • Chapter
HLA Class II Antigens

Overview

HLA class II molecules (Ia) are highly polymorphic cell surface glycoproteins encoded on the short arm of chromosome 6. They have a characteristic dimeric structure formed by two transmembrane glycoproteins of molecular weight about 29 kd(β) and 35 kd(α). Like HLA class I molecules, class II molecules play a critical role in recognition by T cells, but their tissue distribution is restricted primarily to B cells, antigen-presenting cells, and certain activated cells. Three different families of class II molecules have been defined, have strong structural homologies, and are presumed to have had a common evolutionary origin: DR, DQ, and DP. DP behaves as genetic “outsider” in the D region: (a) recombination occurs relatively frequently between DP and DR/DQ (which have not been clearly distinguished by recombination); (b) linkage disequilibrium between DP and DR (or DQ) is much weaker than between DR and DQ. Less DP is found on the cell surface than DR. Like DR, DP induces proliferative and cytotoxic T cell (CTL) responses, but DP-specific responses are often weaker. Finally, an important historical feature which distinguishes DP from DR and DQ is that even now, 5–7 years after its definition, its alleles are defined by cellular techniques rather than by antisera. This review summarizes the current status of studies regarding the function, genetics, structure, and expression of DP; some of the data show differences between DP and other class II molecules but many of them emphasize the similarities. We have tried to be as complete as possible in our reference citations on DP, but have been sparing in other citations.

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Authors
  1. M. Sanchez-Perez
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  2. S. Shaw
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Editors and Affiliations

  1. Blood Bank and Immunohematological Laboratory, Rikshospitalet, National Hospital, Pilestredet 32, N-0027, Oslo 1, Norway

    Bjarte G. Solheim (Director) (Director)

  2. Karolinska Institute, Department of Clinical Immunology, Huddinge Hospital, S-14186, Huddinge, Sweden

    Erna Møller

  3. Dept. of Microbiology and Immunology, New York Medical College, Valhalla, NY, 10595, USA

    Soldano Ferrone

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© 1986 Springer-Verlag Berlin Heidelberg

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Sanchez-Perez, M., Shaw, S. (1986). HLA-DP: Current Status. In: Solheim, B.G., Møller, E., Ferrone, S. (eds) HLA Class II Antigens. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70367-6_6

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  • DOI: https://doi.org/10.1007/978-3-642-70367-6_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70369-0

  • Online ISBN: 978-3-642-70367-6

  • eBook Packages: Springer Book Archive

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