Summary
I. Monoclonal antibody analysis of bat origin virus isolates from South Africa revealed the parallel existence of Mokola and Duvenhage viruses among bats and of classical rabies virus among terrestrial animals of the same ecosystem. A Mokola type virus was causing clinical rabies in a cat from Natal, RSA.
Virus isolates from bats, from Maritime Germany (West) were shown to be identical to African origin Duvenhage virus.
II. An outbreak of rabies on a Norwegian island among mammals including one seal was shown by a particular nucleocapsid antibody to be caused by arctic fox rabies virus which according to this study seems to be restricted to the arctic circle.
III. A particular NC antibody identifying ERA/SAD viruses is presently being used by diagnostic laboratories in Germany and Switzerland to identify vaccine virus used in field trials for the oral immunization of foxes.
An antigenic variant of rabies virus selected by growing virus in the presence of a particular monoclonal antibody and found to be non-pathogenic for adult mice was applied orally to foxes by bait. The variant vaccine induced 100% seroconversion in foxes and proved to be at least equally protective as the vaccines used so far in Swiss and German field trials for the oral immunization of wildlife.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Wiktor TJ, Flamand A, Koprowski H (1980) Use of monoclonal antibodies in diagnosis of rabies virus infection and differentiation of rabies and rabies-related viruses. J Virol Meth 1:33–46
Schneider LG, Meyer S (1981) Antigenic determinants of rabies virus as demonstrated by monoclonal antibody. In: David HL, Bishop Compans RW (eds) The Replication of Negative Strand Viruses. Copyright 1981 by Elsevier North Holland, Inc
Blancou J, Andral L, Mannen K (1982) Variants antigeniques du virus rabique en France. Etude par anticorps monoclonaux. Comp Immun Microbiol infect Dis 5:95–99
Schneider LG (1982) Antigenic variants of rabies virus. Comp Immun Microbiol infect Dis 5:101–107
Sureau P, Rollin PE (1982) Variantes antigeniques du virus rabique: Souches des rues de France, d’Afrique, de Madagascar et d’Asie. Resultats preliminaires obtenus avec des anticorps monoclonaux antinucleocapside. Comp Immun Microbiol infect Dis 5:109–112
Wiktor TJ, Koprowski H (1980) Antigenic variants of rabies virus. J Exp Med 152:99–112
Kantorovich RA (1964) Natural foci of a rabies-like infection in the far north. J Hyg Epid Microbiol Immunol 8:100–110
Schneider LG (1964) Erfahrungen mit fluoreszenzmarkierten Antikörpern bei der routinemäßigen Laboratoriumsdiagnose der Tollwut. I. Die fluoreszierende Antikörpertechnik. Zbl Vet Med 11:207–230
Smith JS, Yager PA, Baer GM (1973) A rapid tissue culture test for determining rabies neutralizing antibody. In: Kaplan MM, Koprowski H (third Edition) Laboratory Techniques in Rabies, pp 354–357
Sedwick WD, Wiktor TJ (1967) Reproducible plaquing system for rabies, lymphocytic choriomeningitis, and other ribonucleic acid viruses in BHK-21/13S agarose suspensions. J Virol 1:1224–1226
Barnard BJH, Hassel RH (1981) Rabies in Kudus (Tragelaphus Strepsiceros) in South West Africa/Namibia. J South Afric Vet Ass 52:309–314
Kemp GE, Causey OR, Moore DL, Odelola A, Fabiyi A (1972) Mokola virus. Further studies on IBAN 27 377. A new rabies-related etiologic agent of zoonosis in Nigeria. Amer J Trop Med 21:356–359
Meredith CD, Rossouw AP, Praag Koch H van (1971) An unusual case of human rabies thought to be of chiropteran origin. S Afr Med J 45:767–769
Crick J, Tignor GH, Moreno K (1981) Lagos bat virus in South Africa. CDC Rab Inf Exchange, June 1981, pp 40–41
See also: Meredith CD, Standing E (1981) Lancet 1:832–833
Boulger LR, Porterfield JS (1958) Isolation of a virus from Nigerian fruit bats. Trans Roy Soc trop Med Hyg 52:421–424
Foggin CM (1982) Atypical rabies in cats and a dog in Zimbabwe. Vet Rec 110:338
Ødegaard ØA, Krogsrud J (1981) Rabies in Svalbard: Infection diagnosed in arctic fox, reindeer and seal. Vet Rec 109:141–142
Steck F, Wandeler A, Bichsel P, Capt S, Schneider LG (1982) Oral immunisation of foxes against rabies. A field study. Zbl Vet Med B 29:372–396
Schneider LG, Cox JH (1983) Ein Feldversuch zur oralen Immunisierung von Füchsen gegen die Tollwut in der Bundesrepublik Deutschland. I. Unschädlichkeit, Wirksamkeit und Stabilität der Vakzine SAD B19. Tierärztl Umschau 38:315–324
Dietzschold B, Wunner WH, Wiktor TJ, Dwight Lopes A, Lafon M, Smith CL, Koprowski H (1983) Characterization of an antigenic determinant of the glycoprotein that correlates with pathogenicity of rabies virus. Proc Natl Acad Sci USA 80:70–74
Coulon P, Rollin P, Blancou J, Flamand A (1982) Avirulent mutants of the CVS strain of rabies virus. Comp Immun Microbiol infect Dis 5:117–122
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Springer-Verlag Berlin, Heidelberg
About this paper
Cite this paper
Schneider, L.G. et al. (1985). Application of Monoclonal Antibodies for Epidemiological Investigations and Oral Vaccination Studies. In: Kuwert, E., Mérieux, C., Koprowski, H., Bögel, K. (eds) Rabies in the Tropics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70060-6_6
Download citation
DOI: https://doi.org/10.1007/978-3-642-70060-6_6
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-13826-6
Online ISBN: 978-3-642-70060-6
eBook Packages: Springer Book Archive