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Clinical Evidence for Functional Compartmentalization of the Cerebellum

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Cerebellar Functions

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

The unique structure of the cerebellum suggests a specific function of this part of the brain. Its nature, however, is poorly understood. Given the anatomical uniformity of the cerebellar cortex one may wonder whether it will be possible to localize functions of a principally different type within the cerebellar mantle. Even, if this were not the case, it is important to realize that there may exist functional localization as the result of the very specific afferent and efferent connections of a particular cerebellar area. Aside from these questions of a more basic significance, it is of clinical importance to know whether there are symptoms that allow for localization. This paper reports on the literature treating the subject and a number of our own studies on patients with postural ataxia and cerebellar disorders of eye movements. A major part of this review has already been published elsewhere (Dichgans 1984). So far the literature mainly contains studies with lesions in animals and rather few studies on patients with lesions that are well limited and precisely localized, e.g. by CT-scanning in recent years.

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References

  • Allen GJ, Tsukahara N (1974) Cerebellar communication systems. Physiol Rev 54: 957–1006

    PubMed  CAS  Google Scholar 

  • Amici R, Avancini G, Pacini L (1976) Cerebellar tumors. Monographs in neural sciences, vol IV. Karger, Basel

    Google Scholar 

  • Avanzini G, Girotti F, Crenna P, Negri S (1979) Alterations of ocular motility in cerebellar pathology. Arch Neurol 36: 274–280

    Article  PubMed  CAS  Google Scholar 

  • Baloh RW, Konrad HR, Honrubia V (1975) Vestibulo-ocular function in patients with cerebellar atrophy. Neurology 25: 160–168

    PubMed  CAS  Google Scholar 

  • Baloh RW, Jenkins HA, Honrubia V, Yee RD, Lau CGY (1979) Visual-vestibular interaction and cerebellar atrophy. Neurology 29: 116–119

    PubMed  CAS  Google Scholar 

  • Baloh RW, Yee RD, Kimm J, Honrubia V (1981) Vestibulo-ocular reflex in patients with lesions involving the vestibulocerebellum. Exp Neurol 72: 141–152

    Article  PubMed  CAS  Google Scholar 

  • Belenkii VYE, Gurfinkel VS, Paltsev YEI (1967) Elements of control of voluntary movements. Biophyzika 12: 135–141

    CAS  Google Scholar 

  • Bouisset S, Zattara M (1981) A sequence of postural movements precedes voluntary movement. Neurosci Lett 22: 263–270

    Article  Google Scholar 

  • Braitenberg V (1967) Is the cerebellar cortex a biological clock in the millisecond range? Prog Brain Res 25: 334–346

    Article  PubMed  CAS  Google Scholar 

  • Brodai A (1981) Neurological anatomy. Oxford Univ Press, New York Oxford

    Google Scholar 

  • Brown JR (1959) Degenerative cerebellar ataxias. Neurology (Minneapolis) 9: 799–805

    CAS  Google Scholar 

  • Burde RM, Stroud MH, Roper-Hall G (1975) Ocular motor dysfunction in total and hemicerebellectomized monkeys. Br J Ophthalmol 59: 560–565

    Article  PubMed  CAS  Google Scholar 

  • Carrea RME, Mettler FA (1955) Function of the primate brachium conjunctivum and related structures. J Comp Neurol 102: 151

    Article  PubMed  CAS  Google Scholar 

  • Chambers BR, Gresty MA (1983) The relationship between disordered pursuit and vestibulo-ocular reflex suppression. J Neurol Neurosurg Physiat 46: 61–66

    Article  CAS  Google Scholar 

  • Cole M (1971) Dysprosody due to posterior fossa lesions. Trans Am Neurol Assoc 96: 151–154

    PubMed  CAS  Google Scholar 

  • Conrad B, Brooks V (1975) Cerebelläre Bewegungsstörungen im Tierversuch. Vergleich rascher Alternativbewegungen and langsamer Zielbewegungen während reversibler Dentatusausschaltung. J Neurol 209: 165–179

    Google Scholar 

  • Cordo PJ, Nashner LM (1982) Properties of postural adjustments associated with rapid arm movements. J Neurophysiol 47: 287–302

    PubMed  CAS  Google Scholar 

  • Dichgans J (1984) Clinical symptoms of cerebellar dysfunction and their topodiagnostical significance. Human Neurobiol 2: 269–279

    CAS  Google Scholar 

  • Dichgans J, Jung R (1975) Oculomotor abnormalities due to cerebellar lesions. In: Lennerstrand G, Bach-y-Rita P (eds) Basic mechanisms of ocular motility and their clinical implications. Perga-mon Press, Oxford New York, pp 281–298

    Google Scholar 

  • Dichgans J, Mauritz KH, Allum JHJ, Brandt TH (1976) Postural sway in normals and ataxic patients. Agressologie 17C: 15–24

    PubMed  CAS  Google Scholar 

  • Dichgans J, Reutern von GM, Römmelt U (1978) Impaired suppression of vestibular nystagmus by fixation in cerebellar and noncerebellar patients. Arch Psychiat Nervenkr 226: 183–193

    Article  PubMed  CAS  Google Scholar 

  • Dichgans J, Diener HC, Mauritz KH (1983) What distinguishes the different kinds of postural ataxia in patients with cerebellar diseases. Adv Otorhinolaryngol 30: 285–287

    PubMed  CAS  Google Scholar 

  • Diener HC, Bootz F, Dichgans J, Bruzek W (1983) Variability of postural “reflexes” in humans. Exp Brain Res 52: 423–428

    Article  PubMed  CAS  Google Scholar 

  • Diener HC, Dichgans J, Bacher M, Hülser J, Liebich H (1983) Mechanisms of postural ataxia after intake of alcohol. Z Rechtsmed, 90: 159–165

    Article  PubMed  CAS  Google Scholar 

  • Diener HC, Dichgans J, Bootz F, Bacher M (1984) Early stabilization of human posture after a sudden disturbance: Influence of rate and amplitude of displacement. Exp Brain Res 56: 126–134

    Google Scholar 

  • Diener HC, Dichgans J, Bacher B, Gompf B (1984) Quantification of postural sway in normals and patients with cerebellar diseases. Electroencephalogr Clin Neurophysiol 57: 134–142

    Article  PubMed  CAS  Google Scholar 

  • Diener HC, Dichgans J, Bacher B, Guschlbauer P (1984) Characteristic alterations of long loop “reflexes” in patients with Friedreich’s disease and late atrophy of the cerebellar anterior lobe. J Neurol Neurosurg Psychiat 47: 679–685

    Article  PubMed  CAS  Google Scholar 

  • Diener HC, Dichgans J, Bacher B, Guschlbauer P (1984) Characteristic alterations of long loop “reflexes” in patients with Friedreich’s disease and late atrophy of the cerebellar anterior lobe. J Neurol Neurosurg Psychiat 47: 679–685

    Article  PubMed  CAS  Google Scholar 

  • Diener HC, Dichgans J, Hülser PJ, Buettner UW, Bacher M, Guschlbauer B (1984) The significance of long loop “reflexes” for the diagnosis of multiple sclerosis. Electroenceph Clin Neurophysiol 57: 336–342

    Article  PubMed  CAS  Google Scholar 

  • Dow RS, Moruzzi G (1958) The physiology and pathology of the cerebellum. Univ of Minnesota Press, Minneapolis

    Google Scholar 

  • Eccles JC (1977) Cerebellar function in the control of movement. In: Rose F (ed) Physiological aspects of clinical neurology. Blackwell, Oxford, pp 157–178

    Google Scholar 

  • Eckmiller R, Westheimer G (1983) Compensation of oculomotor deficits in monkeys with neonatal cerebellar ablations. Exp Brain Res 49: 315–326

    Article  PubMed  CAS  Google Scholar 

  • Evarts EV, Thach WTS (1969) Motor mechanisms of the CNS: cerebro-cerebellar interrelations. Ann Rev Physiol 31: 451–498

    Article  CAS  Google Scholar 

  • Friedemann HH, Noth J, Diener HC, Bacher M (1984) Long latency EMG responses in hand and leg muscles. I. Cerebellar disorders. J Neurol Neurosurg Psychiat (submitted)

    Google Scholar 

  • Fuchs AF, Kornhuber HH (1969) Extraocular muscle afferents to the cerebellum of the cat. J Physiol 200: 713–7 22

    Google Scholar 

  • Gilman S (1969) The mechanism of cerebellar hypotonia: an experimental study in the monkey. Brain 92: 621–638

    Article  PubMed  CAS  Google Scholar 

  • Gilman S, Bloedel JR, Lechtenberg R (1981) Disorders of the cerebellum. Davis, Philadelphia

    Google Scholar 

  • Goldberger ME, Growdon JH (1971) Tremor at rest following cerebellar lesions in monkeys: effect of L-dopa administration. Brain Res 27: 183–187

    Article  PubMed  CAS  Google Scholar 

  • Gonshor A, Melvill-Jones G (1971) Plasticity in the adult human vestibulo-ocular reflex arc. Proc Can Fed Biol Soc 14: 11

    Google Scholar 

  • Hallett M, Shahani BT, Young RR (1975) EMG analysis of patients with cerebellar deficits. J Neurol Neurosurg Psychiat 38: 1163–1169

    Article  PubMed  CAS  Google Scholar 

  • Halmagyi GM, Gresty MA (1979) Clinical signs of visual-vestibular interaction. J Neurol Neurosurg Psychiat 42: 931–939

    Article  Google Scholar 

  • Holmes G (1917) The symptoms of acute cerebellar injuries due to gunshot injuries. Brain 40: 461–535

    Article  Google Scholar 

  • Holmes G (1939) The cerebellum of man. (The Hughlings Jackson memorial lecture). Brain 62: 1–30

    Article  Google Scholar 

  • Hood JD (1981) Further observations on the phenomenon of rebound nystagmus. In: Cohen B (ed) Vestibular and oculomotor physiology. Ann NY Acad Sci 374: 532–539

    Google Scholar 

  • Hood JD, Kayan A, Leech J (1973) Rebound nystagmus. Brain 96: 507–526

    Article  PubMed  CAS  Google Scholar 

  • Koeppen AH, Baron KD, Deutinger MP (1980) Olivary hypertrophy in man. In: Courville J et al. (eds) The inferior olivary nucleus: anatomy and physiology. Raven Press, New York, pp 309–314

    Google Scholar 

  • Lechtenberg R, Gilman S (1978) Speech disorders in cerebellar disease. Ann Neurol 3: 285–290

    Article  PubMed  CAS  Google Scholar 

  • Lee RG, Tatton WG (1975) Motor responses to sudden limb displacements in primates with specific CNS lesions and in human patients with motor system disorders. Can J Neurol Sci 2: 285–293

    PubMed  CAS  Google Scholar 

  • Lisberger SG, Fuchs AF (1978) Role of primate flocculus during rapid behavioural modification of vestibulo-ocular reflex. I. Purkinje cell activity during visually guided horizontal smooth pursuit eye movements and passive head rotation. J Neurophysiol4l: 733–763

    Google Scholar 

  • Llinas R, Volkind RA (1973) The olivo-cerebellar system: Functional properties as revealed by harmaline-induced tremor. Exp Brain Res 18: 69–87

    Google Scholar 

  • MacKay WA, Murphy JT (1979) Cerebellar influence on proprioceptive control loops. In: Massion J, Sasaki K (eds) Cerebro-cerebellar interactions. Elsevier, Amsterdam, pp 141–162

    Google Scholar 

  • Marsden CD, Merton PA, Morton HB, Hallett M, Adam J, Rushton DM (1977) Disorders of movement in cerebellar disease in man. In: Rose F (ed) Physiological aspects of clinical neurology. Blackwell, Oxford, pp 179–199

    Google Scholar 

  • Marsden CD, Merton PA, Morton HB, Adam J (1978) The effect of lesions of the central nervous system on long-latency stretch reflexes in the human thumb. In: Desmedt JE (ed) Cerebral motor control in man: Long loop mechanisms. Karger, Basel, pp 334–341

    Google Scholar 

  • Mauritz KH (1979) Standataxie bei Kleinhirnläsionen. Untersuchungen zur Differentialdiagnostik and Pathophysiologie gestörter Haltungsregulation. Habilitationsschr, Med Fak, Univ Freiburg

    Google Scholar 

  • Mauritz KH, Dichgans J, Hufschmidt A (1979) Quantitative analysis of stance in late cortical cere bellar atrophy of the anterior lobe and other forms of cerebellar ataxia. Brain 102: 461–482

    Article  PubMed  CAS  Google Scholar 

  • Mauritz KH, Schmitt C, Dichgans J (1981) Delayed and enhanced long latency reflexes as the possible cause of postural tremor in late cerebellar atrophy. Brain 104: 97–116

    Article  PubMed  CAS  Google Scholar 

  • Melvill-Jones G, Watt DGD (1971) Observations on the control of stepping and hopping movement in man. J Physiol 219: 709–727

    Google Scholar 

  • Meyer-Lohmann J, Hore J, Brooks VB (1977) Cerebellar participation in generation of prompt arm movements. J Neurophysiol 40: 1038–1050

    PubMed  CAS  Google Scholar 

  • Miles FA (1982) Adaptive gain control in the vestibulo-ocular reflex. In: Lennerstrand G, Zee DS, Keller EL (eds) Functional basis of ocular motility disorders, vol 37. Wenner Gren Symp Perga-mon Press, Oxford, pp 325–337

    Google Scholar 

  • Miles FA, Fuller JH, Braitman DJ, Dow BM (1980) Long-term adaptive changes in primate vestibulo-ocular reflex. III. Electrophysiological observations in flocculus of normal monkeys. J Neurophysiol 43: 1437–1476

    Google Scholar 

  • Nashner LM, Grimm KJ (1978) Analysis of multiloop dyscontrols in standing cerebellar patients. In: Desmed JE (ed) Cerebral motor control in man: Long loop mechanims. Karger, Basel Progr Clin Neurophysiol, vol IV, pp 300–319

    Google Scholar 

  • Neilson PD, Lance JW (1978) Reflex transmission characteristics during voluntary activity in normal man and patients with movement disorders. In: Desmedt JE (ed) Cerebral motor control in man: Long loop mechanisms, Karger, Basel (Progr Clin Neurophysiol, vol IV, pp 263–299 )

    Google Scholar 

  • Noth J, Friedemann HH, Podol HK, Lange HW (1983) Absence of long latency reflexes to imposed finger displacements in patients with Huntington’s disease. Neurosci Letters 35: 97–100

    Article  CAS  Google Scholar 

  • Optican LM, Robinson DA (1980) Cerebellar dependent adaptive control of the primate saccadic system. J Neurophysiol 44: 1058–1076

    PubMed  CAS  Google Scholar 

  • Paltsev YJ, Elner AM (1967) Preparatory and compensatory period during voluntary movement in patients with involvement of the brain of different localization. Biophys J 12: 142–147

    CAS  Google Scholar 

  • Pollock LJ, Davis L (1930) Studies in decerebration VI. The effect of deafferentation upon decere- brate rigidity. Am J Physiol 98: 47

    Google Scholar 

  • Reutern von GM, Dichgans J (1977) Augenbewegungsstörungen als cerebelläre Symptome bei Kleinhirnbrückenwinkeltumoren. Arch Psychiat Nervenkr 223: 117–130

    Article  PubMed  CAS  Google Scholar 

  • Ritchie L (1976) Effects of cerebellar lesions on saccadic eye movements. J Neurophysiol 39: 1246–1252

    PubMed  CAS  Google Scholar 

  • Robinson DA (1976) Adaptive gain control of vestibuloocular reflex by the cerebellum. J Neurophysiol 39: 954–969

    PubMed  CAS  Google Scholar 

  • Robinson DA (1982) A model of cancellation of the vestibulo-ocular reflex. In: Lennerstrand G, Zee DS, Keller EL (eds) Functional basis of ocular motility disorders, vol. 37. Wenner Gren Symp, Pergamon Press, Oxford New York, pp 5–13

    Google Scholar 

  • Rondot P, Bathien N, Toma S (1979) Physiopathology of cerebellar movement. In: Massion J, Sa saki K (eds) Cerebro-cerebellar interactions. Elsevier, Amsterdam New York, pp 203–230

    Google Scholar 

  • Rondot P, Bathien N, Toma S (1979) Physiopathology of cerebellar movement. In: Massion J, Sa saki K (eds) Cerebro-cerebellar interactions. Elsevier, Amsterdam New York, pp 203–230

    Google Scholar 

  • Silfverskiöld BP (1969) Romberg’s test in the cerebellar syndrome occurring in chronic alcoholism. Acta Neurol Scand 45: 292–302

    Article  PubMed  Google Scholar 

  • Suzuki DA, Noda H, Kase M (1981) Visual and pursuit eye movement-related activity in posterior vermis of monkey cerebellum. J Neurophysiol 46: 1120–1139

    PubMed  CAS  Google Scholar 

  • Takemori S, Cohen B (1974) Loss of visual suppression of vestibular nystagmus after flocculus lesions. Brain 72: 213–224

    Article  CAS  Google Scholar 

  • Terzuolo CA, Viviani P (1974) Patterns of motion and EMG activities during some simple motor tasks in normal subjects and cerebellar patients. In: Cooper IS, Riklan M, Snider RS (eds) The cerebellum, epilepsy and behavior. Plenum Press, New York, pp 173–215

    Chapter  Google Scholar 

  • Traub MM, Rothwell JC, Marsden CD (1980) Anticipatory postural reflexes in Parkinson’s disease and other akinetic-rigid syndromes and cerebellar ataxia. Brain 103: 393412

    Google Scholar 

  • Victor M, Adams RD, Mancall EL (1959) A restricted form of cerebellar cortical degeneration occurring in alcoholic patients. Arch Neurol 1: 579–688

    Article  Google Scholar 

  • Vilis T, Hore J (1977) Effects of changes in mechanical state of limb on cerebellar intention tremor. J Neurophysiol 40: 1214–1224

    PubMed  CAS  Google Scholar 

  • Vilis T, Hore J (1980) Central neural mechanisms contributing to cerebellar tremor produced by limb perturbations. J Neurophysiol 43: 279–291

    PubMed  CAS  Google Scholar 

  • Vilis T, Hore J (1981) Characteristics of saccadic dysmetria in monkeys during reversible lesions of medial cerebellar nuclei. J Neurophysiol 46: 828–838

    PubMed  CAS  Google Scholar 

  • Vilis T, Snow R, Hore J (1983) Cerebellar saccadic dysmetria is not equal in the two eyes. Exp Brain Res 51: 343–350

    Article  Google Scholar 

  • Waespe W, Cohen B, Raphan T (1983) Role of the flocculus and paraflocculus in optokinetic nys tagmus and visual-vestibular interactions: effects of lesions. Exp Brain Res 50: 9–33

    Article  PubMed  CAS  Google Scholar 

  • Weisenburg TH (1927) Cerebellar localization and its symptomatology. Brain 50: 357

    Article  Google Scholar 

  • Westheimer G, Blair SM (1973) Oculomotor defects in cerebellectomized monkeys. Invest Opthal mol Vis Sci 12: 618–621

    CAS  Google Scholar 

  • Westheimer G, Blair SM (1974) Functional organization of primate oculomotor system revealed by cerebellectomy. Exp Brain Res 21: 463–472

    Article  PubMed  CAS  Google Scholar 

  • Wiesendanger M, Miles TS (1982) Ascending pathway of low-threshold muscle afferents to the cerebral cortex and its possible role in motor control. Physiol Rev 62: 1234–1270

    PubMed  CAS  Google Scholar 

  • Woollacott MH (1983) Effects of ethanol on postural adjustments in humans. Exp Neurology 80: 55–68

    Article  CAS  Google Scholar 

  • Yagi T, Shimizu M, Sekine S, Kamio T, Suzuki J-I (1981) A new neurotological test for detecting cerebellar dysfunction. In: Cohen B (ed) Vestibular and oculomotor physiology. Ann NY Acad Sci 374: 526–531

    Google Scholar 

  • Zee DS (1982) Ocular motor control: the cerebellum. In: Lessel S, Dalen van JTW (eds) Neuroopthalmology, vol II. Excerpta Medica, Amsterdam Oxford, Princeton, pp 136

    Google Scholar 

  • Zee DS, Friendlich AR, Robinson DA (1974) Mechanisms of downbeat nystagmus. Arch Neurol 30: 227–237

    Article  PubMed  CAS  Google Scholar 

  • Zee DS, Yee RD, Cogan DG, Robinson DA, Engel WK (1976) Oculomotor abnormalities in hereditary cerebellar ataxia. Brain 99: 207–234

    Article  PubMed  CAS  Google Scholar 

  • Zee DS, Yamazaki A, Butler P, Gücer G (1981) Effect of ablation of flocculus and paraflocculus on eye movement in primate. J Neurophysiol 46: 878–899

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Neurology, University of Tübingen, 7400, Tübingen, Germany

    H. C. Diener

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  1. J. Dichgans
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  2. H. C. Diener
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Editors and Affiliations

  1. Barrow Neurological Institute St. Joseph’s Hospital and Medical Center, 350 West Thomas Rd., 85013, Phoenix, Arizona, USA

    James R. Bloedel

  2. Neurologische Klinik, Universität Tübingen, Liebermeisterstraße 18-20, 7400, Tübingen, Germany

    Johannes Dichgans

  3. Institut für Hirnforschung, Universität Zürich, August-Forel-Straße 1, CH-8029, Zürich, Switzerland

    Wolfgang Precht

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Dichgans, J., Diener, H.C. (1984). Clinical Evidence for Functional Compartmentalization of the Cerebellum. In: Bloedel, J.R., Dichgans, J., Precht, W. (eds) Cerebellar Functions. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69980-1_9

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  • DOI: https://doi.org/10.1007/978-3-642-69980-1_9

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