Abstract
The earliest indication of commitment to the B lymphocyte pathway of differentiation is probably the functional rearrangement of a single immunoglobulin (Ig) heavy chain gene. The phenotypic characteristics of these B cell progenitors have not been determined, but their progeny, termed pre-B cells, are known to have rearrangements of both heavy chain genes and to express cell surface antigens Lyb-2 and Ly5(B220) (1,2). Two subpopulations of pre-B cells can be distinguished based on difference in size, rearrrangement of Ig light chain genes, and expression of the cell surface antigen, ThB. Early pre-B cells are large, have no Ig light chain rearrangements and are ThB- whereas their progeny are smaller, have rearranged at least one of their light chain genes, and are ThB+ (1).
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Holmes, K.L., Morse, H.C. (1984). Coexpression of Lyb-2 and Mac-1 by Murine Lymphomas and Subpopulations of Normal Spleen and Bone Marrow Cells. In: Potter, M., Melchers, F., Weigert, M. (eds) Oncogenes in B-Cell Neoplasia. Current Topics in Microbiology and Immunology, vol 113. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69860-6_38
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DOI: https://doi.org/10.1007/978-3-642-69860-6_38
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