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Cellular Distribution and Regulation of Glutamine Synthetase in Liver

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Glutamine Metabolism in Mammalian Tissues

Abstract

In Escherichia coli and in other prokaryotic organisms glutamine is the precursor for syntheses of nitrogenous compounds and is required especially for biosyntheses of nucleic acids and proteins. Consequently, glutamine synthetase is regulated by a complex control system, including repression/derepression of enzyme synthesis [1], cumulative feedback inhibition by metabolic effectors [2], and by metabolite controlled chemical interconversion of the enzyme [3,4]. This highly sophisticated regulation seems to be necessary to adapt these organisms to substrate dependent alterations of energy and nitrogen metabolism [5].

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Authors and Affiliations

  1. Physiologisch-Chemisches Institut der Universität, Hoppe-Seyler-Straße 1, 7400, Tübingen, Germany

    D. Mecke

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  1. R. Gebhardt
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  1. Medizinische Universitätsklinik, Hugstetterstraße 55, 7800, Freiburg, Germany

    Dieter Häussinger

  2. Institut für Physiologische Chemie I, Universität Düsseldorf, Moorenstraβe 5, 4000, Düsseldorf, Germany

    Helmut Sies

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Gebhardt, R., Mecke, D. (1984). Cellular Distribution and Regulation of Glutamine Synthetase in Liver. In: Häussinger, D., Sies, H. (eds) Glutamine Metabolism in Mammalian Tissues. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69754-8_7

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  • DOI: https://doi.org/10.1007/978-3-642-69754-8_7

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