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Decreased Spinal Fluid Monoamine Metabolites and Norepinephrine in Schizophrenic Patients with Brain Atrophy

  • Chapter
Pathochemical Markers in Major Psychoses

Abstract

Spinal fluid studies in schizophrenia have not led to the discovery of consistent differences from normals and other comparison groups (Berger et al. 1980; Post et al. 1975). The frequently observed increased variance in the CSF of schizophrenic patients has been explained by the heterogeneous nature of this illness. Attempts to subgroup schizophrenic patients on the basis of CSF has led to associations between reduced homo vanillic acid (HVA) accumulations after probenecid and patients with a poor prognosis (Bowers 1973), decreased HVA and remitted acute schizophrenics (Post et al. 1975), and elevated norepinephrine (NE) and paranoid patients (Lake et al. 1980). Post et al. (1975) found a correlation between 5-hydroxyindoleacetic acid (5-HIAA) concentrations and Schneiderian first-rank symptoms in acutely ill schizophrenics, and we recently found low 5-HIAA in a small group of schizophrenics with a history of successful or serious suicide attempts (Ninan et al. 1984).

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Authors
  1. D. P. Van Kammen
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  2. Lee S. Mann
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  3. Mika Scheinin
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  4. Philip T. Ninan
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  5. Welmoet B. Van Kammen
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  6. Markku Linnoila
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Editor information

Editors and Affiliations

  1. Psychiatrische Klinik, Zentralinstitut für Seelische Gesundheit Mannheim, Postfach 59 70, D-6800, Mannheim, Germany

    Helmut Beckmann M.D.

  2. Ludwig-Boltzmann-Institut für klinische Neurobiologie, Abteilung Neurochemie, Krankenhaus Wien-Lainz, Pav. XI, Wolkersbergenstraße 1, A-1130, Wien, Austria

    Peter Riederer Ph.D.

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© 1985 Springer-Verlag Berlin Heidelberg

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Van Kammen, D.P., Mann, L.S., Scheinin, M., Ninan, P.T., Van Kammen, W.B., Linnoila, M. (1985). Decreased Spinal Fluid Monoamine Metabolites and Norepinephrine in Schizophrenic Patients with Brain Atrophy. In: Beckmann, H., Riederer, P. (eds) Pathochemical Markers in Major Psychoses. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69743-2_10

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  • DOI: https://doi.org/10.1007/978-3-642-69743-2_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69745-6

  • Online ISBN: 978-3-642-69743-2

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