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Benzodiazepines

  • Chapter
Antiepileptic Drugs

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 74))

Abstract

Drugs of the benzodiazepine class have been introduced in several areas of clinical practice over the past years (Zbinden and Randall 1967; Greenblatt and Shader 1974; Bellantuono et al. 1980). Among their various valuable properties is their potent effect against experimental convulsions and various forms of epilepsy in man (Banziger 1965; Gastaut et al. 1971; Browne and Penry 1973). This property was noted during early animal and clinical studies with chlordiaz-epoxide and diazepam (Randall et al. 1960,1968; Zbinden and Randall 1967), the prototype drugs of this class (Sternbach and Reeder 1961). Subsequent studies with newly developed benzodiazepines revealed similar anticonvulsant activities, differing mainly in quantitative rather than qualitative aspects (Greenblatt and Shader 1974; Garattini et al. 1981).

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Authors
  1. S. Caccia
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  2. S. Garattini
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Editor information

Editors and Affiliations

  1. Laboratorium für Pharmakologie und Toxikologie Fachbereich Veterinärmedizin, Freie Universität Berlin, Koserstraße 20, D-1000, Berlin 33, Germany

    Hans-Hasso Frey

  2. Abteilung für Neurologie, Klinikum Charlottenburg, Spandauer Damm 130, D-1000, Berlin 19, Germany

    Dieter Janz

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© 1985 Springer-Verlag Berlin Heidelberg

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Caccia, S., Garattini, S. (1985). Benzodiazepines. In: Frey, HH., Janz, D. (eds) Antiepileptic Drugs. Handbook of Experimental Pharmacology, vol 74. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69518-6_20

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  • DOI: https://doi.org/10.1007/978-3-642-69518-6_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69520-9

  • Online ISBN: 978-3-642-69518-6

  • eBook Packages: Springer Book Archive

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