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Carbamazepine

  • Chapter
Antiepileptic Drugs

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 74))

Abstract

In the course of work on iminodibenzyl compounds in the laboratories of J. R. Geigy AG the first carbamoyl derivative was synthesized in 1953 and found to possess anticonvulsant properties. This discovery prompted the synthesis of related compounds of which the most promising turned out to be carbamazepine. It was synthesized by Schindler and Blattner in 1957 and published in 1961. Theobald and Kunz investigated the anticonvulsant activity of carbamazepine in the Geigy laboratories and reported on its characteristic spectrum of activity in 1963.

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  1. M. Schmutz
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  1. Laboratorium für Pharmakologie und Toxikologie Fachbereich Veterinärmedizin, Freie Universität Berlin, Koserstraße 20, D-1000, Berlin 33, Germany

    Hans-Hasso Frey

  2. Abteilung für Neurologie, Klinikum Charlottenburg, Spandauer Damm 130, D-1000, Berlin 19, Germany

    Dieter Janz

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Schmutz, M. (1985). Carbamazepine. In: Frey, HH., Janz, D. (eds) Antiepileptic Drugs. Handbook of Experimental Pharmacology, vol 74. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69518-6_16

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  • DOI: https://doi.org/10.1007/978-3-642-69518-6_16

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